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Samoĭlova Iu.G.

GBOU VPO "Sibirskiĭ gosudarstvennyĭ meditsinskiĭ universitet" Minzdrava RF, Tomsk

Rotkank M.A.

Siberian State Medical University, Tomsk, Russia

Zhukova N.G.

Siberian State Medical University, Tomsk, Russia

Matveeva M.V.

Siberian State Medical University, Tomsk, Russia

Tolmachev I.V.

Siberian State Medical University, Tomsk, Russia

Kudlay D.A.

Institute for Advanced Studies of the Federal Medical and Biological Agency, Moscow, Russia

Markers for cognitive impairments and variability of glycaemia in patients with type 1 diabetes mellitus

Authors:

Samoĭlova Iu.G., Rotkank M.A., Zhukova N.G., Matveeva M.V., Tolmachev I.V., Kudlay D.A.

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Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2018;118(4): 48‑51

DOI: 10.17116/jnevro20181184148-51

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MARKERS FOR COGNITIVE IMPAIRMENTS AND VARIABILITY OF GLYCAEMIA IN PATIENTS WITH TYPE 1 DIABETES MELLITUS
MARKERS FOR COGNITIVE IMPAIRMENTS AND VARIABILITY OF GLYCAEMIA IN PATIENTS WITH TYPE 1 DIABETES MELLITUS

To cite this article:

Samoĭlova IuG, Rotkank MA, Zhukova NG, Matveeva MV, Tolmachev IV, Kudlay DA. Markers for cognitive impairments and variability of glycaemia in patients with type 1 diabetes mellitus. S.S. Korsakov Journal of Neurology and Psychiatry. 2018;118(4):48‑51. (In Russ.)
https://doi.org/10.17116/jnevro20181184148-51

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова (S.S. Korsakov Journal of Neurology and Psychiatry)
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Abstract:

Objective. To analyze the relationship between the markers of cognitive impairment and the variability of glycaemia in patients with DM type 1. Material and methods. Patients with DM type 1 and people without DM (the control group) were examined. Neuropsychological testing (MoCA-test), brain MRI and proton magnetic resonance spectroscopy of the brain, as well as parameters of carbohydrate metabolism (fasting blood glucose, glycated hemoglobin and glycemic variability coefficients) were used. Results and сonclusion. Data on the decrease in the overall performance of the MoCA-test (in particular, on assignments to memory and attention domains), atrophic changes in the cerebral cortex and violations of the content of the main metabolites of brain cells in patients with DM type 1 in comparison with the control group were obtained. A number of positive and negative correlations between these disorders and coefficients of glycemic variability were found in patients with DM type 1. The results suggest a significant negative effect of high levels of glycaemia variability on cognitive functions in patients with DM type 1.

Keywords:

cognitive impairments
diabetes mellitus
variability of glycaemia
magnetic resonance imaging
magnetic resonance spectroscopy

Authors:

Samoĭlova Iu.G.

GBOU VPO "Sibirskiĭ gosudarstvennyĭ meditsinskiĭ universitet" Minzdrava RF, Tomsk

Rotkank M.A.

Siberian State Medical University, Tomsk, Russia

Zhukova N.G.

Siberian State Medical University, Tomsk, Russia

Matveeva M.V.

Siberian State Medical University, Tomsk, Russia

Tolmachev I.V.

Siberian State Medical University, Tomsk, Russia

Kudlay D.A.

Institute for Advanced Studies of the Federal Medical and Biological Agency, Moscow, Russia

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References:

  1. Biessels GJ, Staekenborg S, Brunner E, Brayne C, Scheltens P. Risk of dementia in diabetes mellitus: a systematic review. Lancet Neurology. 2006;5:64-74. https://doi.org/10.1016/S1474-4422(05)70284-2
  2. Brands AMA, Biessels GJ, de Haan EHF, Kappelle LJ, Kessels RPC. The Effects of Type 1 Diabetes on Cognitive Performance: A meta-analysis. Diabetes Care. American Diabetes Association. 2005;28(3):726-735. https://doi.org/10.2337/diacare.28.3.726
  3. Kodl CrT, Seaquist ER. Cognitive Dysfunction and Diabetes Mellitus. Endocrine Reviews. 2008;29(4):494-511. https://doi.org/10.1210/er.2007-0034
  4. De Jong RN. The nervous system complications in diabetes mellitus with special reference to cerebrovascular changes. J Nerv Ment Dis. 1950;111:181-206.
  5. Zhao X, Han Q, Lv Y, Sun L, Gang X, Wang G. Biomarkers for cognitive decline in patients with diabetes mellitus: evidence from clinical studies. Oncotarget. 2017;9(7):7710-7726. https://doi.org/10.18632/oncotarget.23284
  6. Moheet A, Mangia S, Seaquist ER. Impact of diabetes on cognitive function and brain structure. Ann NY Acad Sci. 2015;1353:60-71. https://doi.org/10.1111/nyas.12807
  7. Tonoli C, Heyman E, Roelands B, Pattyn N, Buyse L, Piacentini MF, Berthoin S, Meeusen R. Type 1 diabetes-associated cognitive decline: a meta-analysis and update of the current literature. J Diabetes. 2014;6(6):499-513. https://doi.org/10.1111/1753-0407.12193
  8. Febo M, Foster TC. Preclinical Magnetic Resonance Imaging and Spectroscopy Studies of Memory, Aging, and Cognitive Decline. Front Aging Neurosci. 2016;8:158. Published online 2016 Jun 29. https://doi.org/10.3389/fnagi.2016.00158
  9. Maheshwari SR, Fatterpekar GM, Castillo M, Mukherji SK. Proton MR spectroscopy of the brain. Semin Ultrasound CT MR. 2000;21:434-451.
  10. Burtscher IM, Holtas S. Proton MR spectroscopy in clinical routine. J Magn Reson Imaging. 2001;13:560-567. https://doi.org/10.1002/jmri.1079
  11. Danielsen ER, Ross B, eds. Magnetic resonance spectroscopy diagnosis of neurological disease. New York: Marcel Dekker, Inc; 1999.
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