A study on the association of genes for pro-inflammatory cytokines and depression

Lezheĭko T.V.; Andryushchenko A.V.; Korovaĭtseva G.I.; Kondratyev N.V.; Gabaeva M.V.; Krikova E.V.; Golimbet V.E.

doi:https://doi.org/10.17116/jnevro20181183189-93

Lezheĭko T.V.

Nauchnyĭ tsentr psikhicheskogo zdorov'ia RAMN, Moskva

Andryushchenko A.V.

Moscow Scientific and Practical Center of Dermatovenereology and Cosmetology, Moscow, Russia, 119071

Korovaĭtseva G.I.

Nauchnyĭ tsentr psikhicheskogo zdorovia RAMN, Moskva

Kondratyev N.V.

Mental Health Research Center, Moscow, Russia

Gabaeva M.V.

FGBU "Nauchnyĭ tsentr psikhicheskogo zdorov'ia" RAMN, Moskva

Krikova E.V.

Nauchnyĭ tsentr psikhicheskogo zdorov'ia RAMN, Moskva

Golimbet V.E.

Nauchnyĭ tsentr psikhicheskogo zdorov'ia RAMN, Moskva

A study on the association of genes for pro-inflammatory cytokines and depression

Authors:

Lezheĭko T.V., Andryushchenko A.V., Korovaĭtseva G.I., Kondratyev N.V., Gabaeva M.V., Krikova E.V., Golimbet V.E.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2018;118(3): 89‑93

DOI: 10.17116/jnevro20181183189-93

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To cite this article:

Lezheĭko TV, Andryushchenko AV, Korovaĭtseva GI, Kondratyev NV, Gabaeva MV, Krikova EV, Golimbet VE. A study on the association of genes for pro-inflammatory cytokines and depression. S.S. Korsakov Journal of Neurology and Psychiatry. 2018;118(3):89‑93. (In Russ.)
https://doi.org/10.17116/jnevro20181183189-93

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова (S.S. Korsakov Journal of Neurology and Psychiatry)

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Abstract:

Objective. To study the association between proinflammatory cytokine genes and depression. Material and methods. IL-1B С-511T and TNF-a G-308A gene polymorphisms were studied in patients diagnosed with depression and age and sex-matched healthy controls. Results and conclusion. The IL-1B С-511T and TNF-a G-308A polymorphisms were associated with depression; CC genotype (р=0,001, OR=1.9 CI 1,3—2,7) and GG genotype (р=0,001, OR=3,0 CI 1,8—4,9) were the risk factors. The results suggest that immune factors may play a role in the development of depression. The authors highlight the role of clinical polymorphism of depression that makes it difficult to form homogenous groups of patients and to select phenotypes for biological studies.

Keywords:

depression

inflammation

proinflammatory cytokines

interleukins

Authors:

Lezheĭko T.V.

Nauchnyĭ tsentr psikhicheskogo zdorov'ia RAMN, Moskva

Andryushchenko A.V.

Moscow Scientific and Practical Center of Dermatovenereology and Cosmetology, Moscow, Russia, 119071

Korovaĭtseva G.I.

Nauchnyĭ tsentr psikhicheskogo zdorovia RAMN, Moskva

Kondratyev N.V.

Mental Health Research Center, Moscow, Russia

Gabaeva M.V.

FGBU "Nauchnyĭ tsentr psikhicheskogo zdorov'ia" RAMN, Moskva

Krikova E.V.

Nauchnyĭ tsentr psikhicheskogo zdorov'ia RAMN, Moskva

Golimbet V.E.

Nauchnyĭ tsentr psikhicheskogo zdorov'ia RAMN, Moskva

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