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Lezheĭko T.V.

Nauchnyĭ tsentr psikhicheskogo zdorov'ia RAMN, Moskva

Andryushchenko A.V.

Moscow Scientific and Practical Center of Dermatovenereology and Cosmetology, Moscow, Russia, 119071

Korovaĭtseva G.I.

Nauchnyĭ tsentr psikhicheskogo zdorovia RAMN, Moskva

Kondratyev N.V.

Mental Health Research Center, Moscow, Russia

Gabaeva M.V.

FGBU "Nauchnyĭ tsentr psikhicheskogo zdorov'ia" RAMN, Moskva

Krikova E.V.

Nauchnyĭ tsentr psikhicheskogo zdorov'ia RAMN, Moskva

Golimbet V.E.

Nauchnyĭ tsentr psikhicheskogo zdorov'ia RAMN, Moskva

A study on the association of genes for pro-inflammatory cytokines and depression

Authors:

Lezheĭko T.V., Andryushchenko A.V., Korovaĭtseva G.I., Kondratyev N.V., Gabaeva M.V., Krikova E.V., Golimbet V.E.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2018;118(3): 89‑93

DOI: 10.17116/jnevro20181183189-93

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To cite this article:

Lezheĭko TV, Andryushchenko AV, Korovaĭtseva GI, Kondratyev NV, Gabaeva MV, Krikova EV, Golimbet VE. A study on the association of genes for pro-inflammatory cytokines and depression. S.S. Korsakov Journal of Neurology and Psychiatry. 2018;118(3):89‑93. (In Russ.)
https://doi.org/10.17116/jnevro20181183189-93

 
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Objective. To study the association between proinflammatory cytokine genes and depression. Material and methods. IL-1B С-511T and TNF-a G-308A gene polymorphisms were studied in patients diagnosed with depression and age and sex-matched healthy controls. Results and conclusion. The IL-1B С-511T and TNF-a G-308A polymorphisms were associated with depression; CC genotype (р=0,001, OR=1.9 CI 1,3—2,7) and GG genotype (р=0,001, OR=3,0 CI 1,8—4,9) were the risk factors. The results suggest that immune factors may play a role in the development of depression. The authors highlight the role of clinical polymorphism of depression that makes it difficult to form homogenous groups of patients and to select phenotypes for biological studies.

Keywords:

depression
inflammation
proinflammatory cytokines
interleukins

Authors:

Lezheĭko T.V.

Nauchnyĭ tsentr psikhicheskogo zdorov'ia RAMN, Moskva

Andryushchenko A.V.

Moscow Scientific and Practical Center of Dermatovenereology and Cosmetology, Moscow, Russia, 119071

Korovaĭtseva G.I.

Nauchnyĭ tsentr psikhicheskogo zdorovia RAMN, Moskva

Kondratyev N.V.

Mental Health Research Center, Moscow, Russia

Gabaeva M.V.

FGBU "Nauchnyĭ tsentr psikhicheskogo zdorov'ia" RAMN, Moskva

Krikova E.V.

Nauchnyĭ tsentr psikhicheskogo zdorov'ia RAMN, Moskva

Golimbet V.E.

Nauchnyĭ tsentr psikhicheskogo zdorov'ia RAMN, Moskva

List of references:

  1. Smulevich AB. Depressions at mental and somatic diseases. M.: MIA; 2015. (In Russ.)
  2. Neznanov NG, Mazo GE, Kozlova SN. Pathophysiological mechanisms of formation of a depression. In the book: Smulevich A.B. Depressions at Mental and Somatic Diseases. Prod. 4 processed and added. OOO «Medical News Agency publishing hous»; 2015. PMID:26356156. (In Russ.)
  3. Dunn AJ. Effects of cytokines and infections on brain neurochemistry. Clinical Neuroscience Research. 2006;6:1-2:52-68. https://doi.org/10.1016/j.cnr.2006.04.002
  4. Loftis JM, Huckans M, Morasco BJ. Neuroimmune mechanisms of cytokine-induced depression: current theories and novel treatment strategies. Neurobiology of Disease. 2010;37:519-533. https://doi.org/10.1016/j.nbd.2009.11.015
  5. Handaker GM, Cousins L, Deakin J, Lennox BR, Yolken R, Jones PB. Inflammation and immunity in schizophrenia: implication for pathophysiology and treatment. The Lancet Psychiatry. 2015;2:3:258-270. https://doi.org/10.1016/S2215-0366(14)00122-9
  6. Smith WB, Gamble JR, Clarc-Lewis I, Vadas MA. Interleukin-8 induces neutrophil transendothelial migration. Immunology. 1991;72:65-72. PMCID: PMC1384337
  7. Dovlati Yu, Herrmann N, Swardfager B, Liu X, Sham L, Reim EK, Lankto KL. Meta-analiz of cytokines in a big depression. Biol Psychiatry. 2010;67:446-457. https://doi.org/10.1016j.biopsych.2009.09.033
  8. Howren MB, Lamkin DM, Shuls J. Associations of a depression from S-jet protein, IL-1 and IL-6: Meta-analysis. Psychosom Med. 2009;71:171-186. https://doi.org/10.1097PSY.0b013e3181907c1b
  9. Flint J, Kendler KS. The genetics of major depression. Neuron. 2014;81(3):484-503. https://doi.org/10.1016/j.neuron.2014.01.027
  10. Shelton RC, Claiborne J, Sidoryk-Wegrzynowicz M, Reddy R, Aschner M, Lewis D.A, Mirnics K. Altered expression of genes involved in inflammation and apoptosis in frontal cortex in major depression. Mol Psychiatry. 2011;16:7:751-762. https://doi.org/10.1038/mp.2010.52
  11. Hutyrová B, Pantelidis P, Drábek J, Zůrková M, Kolek V, Lenhart K, Welsh KI, Du Bois RM, Petrek M. Interleukin-1 gene cluster polymorphisms in sarcoidosis and idiopathic pulmonary fibrosis. Am J Respir Crit Care Med. 2002;15:165(2):148-151. https://doi.org/10.1164/ajrccm.165.2.2106004
  12. Azouz A, Razzaque M.S, El-Hallak M, Taguchi T. Immunoinflammatory responses and fibrogenesis. Med Electron Microsc. 2004;37(3):141-148. https://doi.org/10.1007/s00795-004-0255-2
  13. Kim JM, Stewart R, Kim SY, Kang HJ, Jang JE, Kim SW, Shin IS, Park MH, Yoon JH, Park SW, Kim YH, Yoon JS. A one year longitudinal study of cytokine genes and depression in breast cancer. J Affect Disord. 2013;148(1):57-65. https://doi.org/10.1016/j.jad.2012.11.048
  14. Hwang JP, Tsai SJ, Hong CJ, Yang CH, Hsu CD, Liou YJ. Interleukin-1 beta -511C/T genetic polymorphism is associated with age of onset of geriatric depression. Neuromolecular Med. 2009;11(4):322-327. https://doi.org/10.1007/s12017-009-8078-x
  15. Kang HJ, Bae KY, Kim SW, Shin IS, Hong YJ, Ahn Y, Jeong MH, Yoon JS, Kim JM. Relationship between interleukin-1β and depressive disorder after acute coronary syndrome. Prog Neuropsychopharmacol Biol Psychiatry. 2017;72:55-59. https://doi.org/10.1016/j.pnpbp.2016.09.001
  16. Kim JM, Kang HJ, Kim JW, Bae KY, Kim SW, Kim JT, Park MS, Cho KH. Associations of Tumor Necrosis Factor-α and Interleukin-1β Levels and Polymorphisms with Post-Stroke Depression. Am J Geriatr Psychiatry. 2017. pii: S1064-7481(17)30411-6. https://doi.org/10.1016/j.jagp.2017.07.012
  17. Udina M, Moreno-España J, Navinés R, Giménez D, Langohr K, Gratacòs M, Capuron L, de la Torre R, Solà R, Martín-Santos R. Serotonin and interleukin-6: the role of genetic polymorphisms in IFN-induced neuropsychiatric symptoms. Psychoneuroendocrinology. 2013;38(9):1803-1813. https://doi.org/10.1016/j.psyneuen.2013.03.007
  18. Jun TY, Pae CU, Hoon H, Chae JH, Bahk WM, Kim KS, Serretti A. Possible association between G-308A tumor necrosis factor-alpha gene polymorphism and major depressive disorder in the Korean population. Psychiatr Genet. 2003;13:179-181. https://doi.org/10.1097/01.ypg.0000066962.66429.49
  19. Kim JM, Stewart R, Kim SW, Shin IS, Kim JT, Park MS, Park SW, Kim YH, Cho KH, Yoon JS. Associations of cytokine gene polymorphisms with post-stroke depression. World J Biol Psychiatry. 2012;12(8):579-587. https://doi.org/10.3109/15622975.2011.588247
  20. Cerri AP, Arosio B, Viazzoli C, Confalonieri R, Teruzzi F, Annoni G. TNF-alpha-308(G/A) gene polymorphism and risk of depression late in the life. Arch Gerontol Geriatr. 2009;49(suppl 1):29-34. https://doi.org/10.1016/j.archger.2009.09.009
  21. Mihailova S, Ivanova-Genova E, Lukanov T, Stoyanova V, Milanova V, Naumova E. A study of TNF-α, TGF-β, IL-10, IL-6, and IFN-γ gene polymorphisms in patients with depression. Neuroimmunol. 2016;293:123-128. https://doi.org/10.1016/j.jneuroim.2016.03.005
  22. Bufalino C, Hepgul N, Aguglia E, Pariante CM. The role of immune genes in the association between depression and inflammation: a review of recent clinical studies. Brain Behav Immun. 2013;31:31-47. https://doi.org/10.1016/j.bbi.2012.04.009
  23. Borkowska P, Kucia K, Rzezniczek S, Paul-Samojedny M, Kowalczyk M, Owczarek A, Suchanek R, Medrala T, Kowalski J.Interleukin-1beta promoter (-31T/C and -511C/T) polymorphisms in major recurrent depression. J Mol Neurosci. 2011;44(1):12-16. https://doi.org/10.1007/s12031-011-9507-5
  24. Lang UE, Borgwardt S. Molecular mechanisms of depression: perspectives on new treatment strategies. Cell Physiol Biochem. 2013;31(6):761-777. https://doi.org/10.1159/000350094
  25. Evans DL, Ten Have TR, Douglas SD, Gettes DR, Morrison M, Chiappini MS, Brinker-Spence P, Job C, Mercer DE, Wang YL, Cruess D, Dube B, Dalen EA, Brown T, Bauer R, Petitto JM.Association of depression with viral load, CD8 T lymphocytes, and natural killer cells in women with HIV infection. Am J Psychiatry. 2002;159:1752-1759. https://doi.org/10.1176/appi.ajp.159.10.1752
  26. Miller AH, Maletic V, Raison CL. Inflammation and its discontents: the role of cytokines in the pathophysiology of major depression. Biol Psychiatry. 2009;65:7392-7419. https://doi.org/10.1016/j.biopsych.2008.11.029
  27. Spindola LM, Pan PM, Moretti PN, Ota VK, Santoro ML, Cogo-Moreira H, Gadelha A, Salum G, Manfro GG, Mari JJ, Brentani H, Grassi-Oliveira R, Brietzke E, Miguel EC, Rohde LA, Sato JR, Bressan RA, Belangero SI. Gene expression in blood of children and adolescents: Mediation between childhood maltreatment and major depressive disorder. J Psychiatr Res. 2017;92:24-30. https://doi.org/10.1016/j.jpsychires.2017.03.015
  28. Stepanichev M, Dygalo NN, Grigoryan G, Shishkina GT, Gulyaeva N Rodent models of depression: neurotrophic and neuroinflammatory biomarkers. Biomed Res Int. 2014;932757. https://doi.org/10.1155/2014/932757
  29. Maes M. The cytokine hypothesis of depression: inflammation, oxidative & nitrosative stress (IO&NS) and leaky gut as new targets for adjunctive treatments in depression. Neuro Endocrinol Lett. 2008;29(3):287-291. PMID: 18580840
  30. Mendlovic S, Mozes E, Eilat E, Doron A, Lereya J, Zakuth V, Spirer Z. Immune activation in non-treated suicidal major depression. Immunol Lett. 1999;67(2):105-108. PMID:10232390

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