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Solov'eva É.Iu.

Kafedra nevrologii FUV GOU VPO RGMU, Moskva

Karneev A.N.

Chekanov A.V.

Baranova O.A.

Rossiĭskiĭ natsional'nyĭ issledovatel'skiĭ meditsinskiĭ universitet im. N.I. Pirogova;
Nauchno-issledovatel'skiĭ institut fiziko-khimicheskoĭ meditsiny FMBA Rossii, laboratoriia fiziko-khimicheskikh metodov issledovaniia i analiza, Moskva

Choi I.V.

Pirogov Russian National Research Medical University, Moscow, Russia

Complex application 2-ethyl-6-methyl-3-hydroxypyridine-succinate and vinpocetine in cerebrovascular disorder.

Authors:

Solov'eva É.Iu., Karneev A.N., Chekanov A.V., Baranova O.A., Choi I.V.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2017;117(5): 103‑108

DOI: 10.17116/jnevro201711751103-108

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Table of contents

COMPLEX APPLICATION 2-ETHYL-6-METHYL-3-HYDROXYPYRIDINE-SUCCINATE AND VINPOCETINE IN CEREBROVASCULAR DISORDER.
COMPLEX APPLICATION 2-ETHYL-6-METHYL-3-HYDROXYPYRIDINE-SUCCINATE AND VINPOCETINE IN CEREBROVASCULAR DISORDER.

To cite this article:

Solov'eva ÉIu, Karneev AN, Chekanov AV, Baranova OA, Choi IV. Complex application 2-ethyl-6-methyl-3-hydroxypyridine-succinate and vinpocetine in cerebrovascular disorder.. S.S. Korsakov Journal of Neurology and Psychiatry. 2017;117(5):103‑108. (In Russ.)
https://doi.org/10.17116/jnevro201711751103-108

Подписка 2025-2 (S.S. Korsakov Journal of Neurology and Psychiatry)
 
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Developing brain ischemia due to cerebral vascularization leads to disruption of brain metabolism. Chronic cerebral hypoperfusion leads to irreversible brain damage and plays an important role in the development of some types of dementia. Early use of antioxidants such as ethyl ether apovincamine acid (vinpocetine) and 2-ethyl-6-methyl-3-hydroxypyridine-succinate in the treatment of this pathology is seen as a real pathogenetically based method of correction of cerebral metabolism with cerebral vascular disorders, demonstrating the increase in cerebral blood flow and also neuroprotective effects. Clinical studies and studies on biological models show that the main mechanisms of action of vinpocetine and 2-ethyl-6-methyl-3-hydroxypyridine-succinate, although have a similar focus, but implementing neuroprotective and nootropic effects via various links in the pathogenesis of ischemic brain damage.

Keywords:

endothelium
platelets
vascular oxidation
inflammation
hemostasis
neuroprotection
Vinpocetine
2-ethyl-6-methyl-3-hydroxypyridine-succinate
ischemia
atherosclerosis

Authors:

Solov'eva É.Iu.

Kafedra nevrologii FUV GOU VPO RGMU, Moskva

Karneev A.N.

Chekanov A.V.

Baranova O.A.

Rossiĭskiĭ natsional'nyĭ issledovatel'skiĭ meditsinskiĭ universitet im. N.I. Pirogova;
Nauchno-issledovatel'skiĭ institut fiziko-khimicheskoĭ meditsiny FMBA Rossii, laboratoriia fiziko-khimicheskikh metodov issledovaniia i analiza, Moskva

Choi I.V.

Pirogov Russian National Research Medical University, Moscow, Russia

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