The biomarkers of cerebral ischemia as a new method for the validation of the efficacy of cytoprotective therapy

Dambinova S.A.; Aliev K.T.; Bondarenko E.V.; Ponomarev G.V.; Skoromets A.A.; Skoromets A.P.; Skoromets T.A.; Smolko D.G.; Shumilina M.V.

doi:https://doi.org/10.17116/jnevro20171175162-67

Dambinova S.A.

Akademicheskaia gruppa akad. RAMN A.A. Skoromtsa (Universitet Émori - Atlanta, SShA);
Sankt-Peterburgskiĭ gosudarstvennyĭ meditsinskiĭ universitet im. I.P. Pavlova

Aliev K.T.

Sankt-Peterburgskiĭ gosudarstvennyĭ meditsinskiĭ universitet im. I.P. Pavlova;
Gorodskaia bol'nitsa #31 im. Ia.M. Sverdlova, Sankt-Peterburg

Bondarenko E.V.

Pavlov First St. Petersburg State Medical University, St. Petersburg, Russia

ORCID: 0000-0003-2122-2297

Ponomarev G.V.

Pavlov First St. Petersburg State Medical University, St. Petersburg, Russia

Skoromets A.A.

Sankt-Peterburgskiĭ gosudarstvennyĭ meditsinskiĭ institut im. akad. I.P. Pavlova

Skoromets A.P.

Akademicheskaia gruppa akad. RAMN A.A. Skoromtsa (Universitet Émori - Atlanta, SShA);
Sankt-Peterburgskiĭ gosudarstvennyĭ meditsinskiĭ universitet im. I.P. Pavlova

ORCID: 0000-0001-7439-2690

Skoromets T.A.

Akademicheskaia gruppa akad. RAMN A.A. Skoromtsa (Universitet Émori - Atlanta, SShA);
Sankt-Peterburgskiĭ gosudarstvennyĭ meditsinskiĭ universitet im. I.P. Pavlova

Smolko D.G.

Sankt-Peterburgskiĭ gosudarstvennyĭ meditsinskiĭ universitet im. akad. I.P. Pavlova

Shumilina M.V.

Akademicheskaia gruppa akad. RAMN A.A. Skoromtsa (Universitet Émori - Atlanta, SShA);
Sankt-Peterburgskiĭ gosudarstvennyĭ meditsinskiĭ universitet im. I.P. Pavlova

Scopus AuthorID: 6507018914
ORCID: 0000-0001-7439-2690

The biomarkers of cerebral ischemia as a new method for the validation of the efficacy of cytoprotective therapy

Authors:

Dambinova S.A., Aliev K.T., Bondarenko E.V., Ponomarev G.V., Skoromets A.A., Skoromets A.P., Skoromets T.A., Smolko D.G., Shumilina M.V.

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Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2017;117(5): 62‑67

DOI: 10.17116/jnevro20171175162-67

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To cite this article:

Dambinova SA, Aliev KT, Bondarenko EV, et al. . The biomarkers of cerebral ischemia as a new method for the validation of the efficacy of cytoprotective therapy. S.S. Korsakov Journal of Neurology and Psychiatry. 2017;117(5):62‑67. (In Russ.)
https://doi.org/10.17116/jnevro20171175162-67

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова (S.S. Korsakov Journal of Neurology and Psychiatry)

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Abstract:

Objective. To study blood plasma concentrations of NR2-peptide in patients with ischemic stroke (IS) to assess its diagnostic value as a biomarker of cerebral ischemia and determine the dynamics of the biomarker during treatment with cortexin. Material and methods. One hundred and twenty patients, aged from 18 to 70 years, including 36 with transient ischemic attack (TIA) and 84 with IS in the carotid territory (n=70) and vertebral/basilar territory with the Wallenberg-Zakharchenko syndrome (n=14), were enrolled. The National Institute of Health Stroke scale (NIHSS) was used to assess neurological status. Blood plasma concentration of NR2-peptide was measured in all patients at admission and after treatment. All laboratory results were compared with neuroimaging (MRI, CT) data. Results. Concentrations of NR2-peptide detected in all patients were higher than in controls (>1.5 ng/ml), p<0.0001. The direct correlation between NR2-peptide (from 3.38 ng/ml to 15.6 ng/ml) and ischemic lesion (from few to 80 mm) was observed. A decrease in NR2-peptide concentration (from 8.5 to 5,.9 ng/ml, p<0.0001) was noted in patients treated with cortexin after 10-day treatment course. Conclusion. NR2-peptide blood assay is a reliable hemotest of brain ischemia. Cortexin has a sufficient therapeutic efficacy.

Keywords:

stroke

diagnosis

biomarker of cerebral ischemia

NR2-peptide

treatment

cortexin

Authors:

Dambinova S.A.

Akademicheskaia gruppa akad. RAMN A.A. Skoromtsa (Universitet Émori - Atlanta, SShA);
Sankt-Peterburgskiĭ gosudarstvennyĭ meditsinskiĭ universitet im. I.P. Pavlova

Aliev K.T.

Sankt-Peterburgskiĭ gosudarstvennyĭ meditsinskiĭ universitet im. I.P. Pavlova;
Gorodskaia bol'nitsa #31 im. Ia.M. Sverdlova, Sankt-Peterburg

Bondarenko E.V.

Pavlov First St. Petersburg State Medical University, St. Petersburg, Russia

ORCID: 0000-0003-2122-2297

Ponomarev G.V.

Pavlov First St. Petersburg State Medical University, St. Petersburg, Russia

Skoromets A.A.

Sankt-Peterburgskiĭ gosudarstvennyĭ meditsinskiĭ institut im. akad. I.P. Pavlova

Skoromets A.P.

Akademicheskaia gruppa akad. RAMN A.A. Skoromtsa (Universitet Émori - Atlanta, SShA);
Sankt-Peterburgskiĭ gosudarstvennyĭ meditsinskiĭ universitet im. I.P. Pavlova

ORCID: 0000-0001-7439-2690

Skoromets T.A.

Akademicheskaia gruppa akad. RAMN A.A. Skoromtsa (Universitet Émori - Atlanta, SShA);
Sankt-Peterburgskiĭ gosudarstvennyĭ meditsinskiĭ universitet im. I.P. Pavlova

Smolko D.G.

Sankt-Peterburgskiĭ gosudarstvennyĭ meditsinskiĭ universitet im. akad. I.P. Pavlova

Shumilina M.V.

Akademicheskaia gruppa akad. RAMN A.A. Skoromtsa (Universitet Émori - Atlanta, SShA);
Sankt-Peterburgskiĭ gosudarstvennyĭ meditsinskiĭ universitet im. I.P. Pavlova

Scopus AuthorID: 6507018914
ORCID: 0000-0001-7439-2690

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References:

Hand PJ, Kwan J, Lindley RI, Dennis MS, Wardlaw JM. Distinguishing between stroke and mimic at the bedside: the brain attack study. Stroke. 2006;37:769-775. doi:10.1161/01.STR.0000204041.13466.4c
Hemmen TM, Meyer BC, McClean TL, Lyden PD. Identification of nonischemic stroke mimics among 411 code strokes at the University of California, San Diego, Stroke Center. J Stroke Cerebrovasc Dis. 2008;17:23-25. doi:10.1016/j.strokecerebrovasdis.2007.09.008
Vroomen PC, Buddingh MK, Luijckx GJ, De Keyser J. The incidence of stroke mimics among stroke department admissions in relation to age group. J Stroke Cerebrovasc Dis. 2008;17:418-422. doi:10.1016/j.strokecerebrovasdis.2008.06.007
von Kummer R, Nolte PN, Schnittger H, Thron A, Ringelstein EB. Detectability of cerebral hemisphere ischemic infarcts by CT within 6 h of stroke. Neuroradiol. 1996;38:31-33.
Hand PJ, Wardlaw JM, Rowat AM, Haisma JA, Lindley RI, Dennis MS. Magnetic resonance brain imaging in patients with acute stroke: feasibility and patient related difficulties. J Neurol Neurosurg Psychiatry. 2005;76:1525-1527. doi:10.1136/jnnp.2005.062539
Warlow C, Sudlow C, Dennis M, Wardlaw J, Sandercock P. Stroke. Lancet. 2003;362:1211-1224. doi:10.1016/S0140-6736(03)14544-8
Furie KL, Kasner SE, Adams RJ, Albers GW, Bush RL, Fagan SC, Halperin JL, Johnston SC, Katzan I, Kernan WN, Mitchell PH, Ovbiagele B, Palesch YY, Sacco RL, Schwamm LH, Wassertheil-Smoller S, Turan TN, Wentworth D. Guidelines for the prevention of stroke in patients with stroke or transient ischemic attack. A guideline for healthcare professionals from the American Heart Association/American Stroke Association. Stroke. 2011;42:227-276. doi:10.1161/STR.0b013e3181f7d043
Whiteley W, Tseng MC, Sandercock P. Blood biomarkers in the diagnosis of ischemic stroke. A systematic review. Stroke. 2008;39:2902-2909. doi:10.1161/STROKEAHA.107.511261
Bettermann K. Biomarkers for stroke: in search of fingerprints. J Stroke Cerebrovasc Dis. 2011;20:173-176. doi:10.1016/j.jstrokecerebrovasdis.2011.02.003
Betzen C, White R, Zehendner CM, Pietrowski E, Bender B, Luhmann HJ, Kuhlmann RW. Oxidative stress upregulates the NMDA receptor on cerebrovascular endothelium. Free Radical Biol Med. 2009;47:1212-1220. doi:10.1016/j.freeradbiomed.2009.07.034
Sharp CD, Fowler M, Jackson TH, Houghton J, Warren A, Nanda A, Chandler I, Cappell B, Long A, Minagar A, Alexander JS. Human neuroepithelial cells express NMDA receptors. BMC Neurosci. 2003;4:28-32. doi:10.1186/1471-2202-4-28
Dambinova SA. Biomarkers for transient ischemic attack and ischemic stroke. Clin Lab Int. 2008;32:7-10.
Gappoeva MU, Izykenova GА, Granstrem OK, Dambinova SA. NMDA receptor mRNA expression in experimental ischemia. Biokhimia. 2003;68:696-702. doi:10.1023/A:1024678112357
Skoromets AA, Skoromets AP, Skoromets TA. Topical diagnosis of the nervous systems diesases. 9nd ed. St. Petersburg: Politekhnika; 2014. (In Russ.).
Barry H, Byrne S, Barrett E, Murphy KC, Cotter DR. Anti-N-methyl-D-aspartate receptor encephalitis: review of clinical presentation, diagnosis and treatment. BJPsych Bull. 2015;39:19-23. doi:10.1192/pb.bp.113.045518
Dambinova SA, Skoromets AA, Skoromets AP. Biomarkers of cerebral ischemia (design, research and practice). St. Petersburg: IPK KOSTA; 2013. (In Russ.).
Weissman JD, Khunteev GA, Heath R, Dambinova SA. NR2 antibodies: risk assessment of transient ischemic attack (TIA)/stroke in patients with history of isolated and multiple cerebrovascular events. J Neurol Sci. 2011;300:97-102. doi:10.1016/j.jns.2010.09.023
Stakhovskaya LV, Meshkova KS, Dadasheva MN, Chefranova ZhYu, Titova LP, Lokshtanova TM, Zelenkina NYu, Alifirova VM, Pugachenko NV, Antukhova OM, Kovalenko AV, Doronin BM, Gordienko NYu, Shekhovtsova KV, Salimov KA, Shamalov NA. Results of multicenter randomize prospective double-blind placebo-controlled study of the safety and efficacy of cortexin in acute and subacute periods of hemispheric ischemic stroke. Vestnik Rossiiskoi voenno-meditsinskoi akademii. 2012;37(1):238-244. (In Russ.).
Tanashyan MM, Barkhatov DYu, Glotova Tanashyan MM, Barkhatov DY, Glotova NA, Konovalov RN, Fedin PA, Guriev MN, Ketlinskaya OS. The efficiency of neuroprotection patients with chronic cerebrovascular disease. Vestnik Rossiiskoi voenno-meditsinskoi akademii. 2011;35(3):181-187. (In Russ.).
Skoromets AA, Skoromets AP, Skoromets TA. Neurological status and his interpretation. Training manual for doctors. Edited by Professor M. M. Dyakonov. 2nd ed, revised and enlarged. M.: MEDpress-inform; 2010. (In Russ.).