Objective. To explore the relationship of depression and its endophenotypes (neuroticism and trait anxiety) with inflammatory genes in patients with coronary heart disease (CHD). Material and methods. A sample consisted of 78 male CHD patients with depression, 91 CHD patients without depression and 127 healthy men. Polymorphisms of the genes encoding interleukine-4 (IL-4 –589 C/T), interleukine-6 (IL-6 –174 G/C), tumor-necrosis factor alpha (TNF-α –308 G/A) and C-reactive protein (CRP –717A/G) were studied. Results. There was the association between the IL-6 –174 G/C and depression comorbid to CHD (р=0.01; OR=2.3 CI 95% 1.2—4.3). The frequency of the «high expression» allele G in this group was higher compared to controls. The association between IL-4 –589 C/T and CHD was found. Compared to the control group, the frequency of the IL-4 –589CC genotype was higher in patients regardless of whether they had symptoms of depression (р=0.007; OR=2.1 CI 95% 1.2—3.4). No association between the TNF-α –308G/A and the CRP –717A/G with depression in CHD was observed. There were no differences between neuroticism and anxiety scores in patients with different IL-4 –589 C/T, IL-6 –174 G/C, TNF-α –308 G/A, CRP –717A/G genotypes. Conclusion. The finding of the association between the IL-6 –174G/C and depression, comorbid to CHD, is in line with literature on a role of IL-6 in the development of depression in patients with CHD.