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Iskra D.A.

Kirov Military Medical Academy, Saint-Petersburg, Russia

Lobzin V.Iu.

Kafedra nervnykh bolezneĭ i kafedra psikhiatrii Voenno-meditsinskoĭ akademii, Sankt-Peterburg

Kalygin S.A.

Kirov Military Medical Academy, St. Petersburg, Russia

Primary headache — risk factor or comorbid pathology in cognitive impairment

Authors:

Iskra D.A., Lobzin V.Iu., Kalygin S.A.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2017;117(12): 141‑146

DOI: 10.17116/jnevro2017117121141-146

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Table of contents

PRIMARY HEADACHE — RISK FACTOR OR COMORBID PATHOLOGY IN COGNITIVE IMPAIRMENT
PRIMARY HEADACHE — RISK FACTOR OR COMORBID PATHOLOGY IN COGNITIVE IMPAIRMENT

To cite this article:

Iskra DA, Lobzin VIu, Kalygin SA. Primary headache — risk factor or comorbid pathology in cognitive impairment. S.S. Korsakov Journal of Neurology and Psychiatry. 2017;117(12):141‑146. (In Russ.)
https://doi.org/10.17116/jnevro2017117121141-146

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова (S.S. Korsakov Journal of Neurology and Psychiatry)
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Abstract:

Currently, the relationship between headache and dementia is considered more widely than just a comorbidity. The severity of migraine and tension-type headache and the severity of cognitive impairment are strongly correlated. Common pathophysiological mechanisms underlie the relationship between primary headache and cognitive impairment. Antinociceptive changes in primary headaches and in glutamate excitotoxicity in dementia developed due to hyper excitability of NMDA receptors are strongly interdependent. It is important in the aspect of possible correction of this pathology by NMDA-antagonists. Memantine not only slows the progression of cognitive symptoms in dementia, but also significantly influences the frequency and severity of primary headache.

Keywords:

primary headache
dementia
migraine
Alzheimer’s disease
tension-type headache
central sensitization
NMDA receptors

Authors:

Iskra D.A.

Kirov Military Medical Academy, Saint-Petersburg, Russia

Lobzin V.Iu.

Kafedra nervnykh bolezneĭ i kafedra psikhiatrii Voenno-meditsinskoĭ akademii, Sankt-Peterburg

Kalygin S.A.

Kirov Military Medical Academy, St. Petersburg, Russia

Close metadata

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