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Gromova O.A.

Rossiĭskiĭ satellitnyĭ tsentr instituta mikroélementov IuNESKO;
Laboratoriia vychislitel'noĭ i sistemnoĭ biologii VTs RAN im. A.A. Dorodnitsyna;
kafedra farmakologii i klinicheskoĭ farmakologii Ivanovskoĭ gosudarstvennoĭ meditsinskoĭ akademii

Torshin I.Iu.

Rossiĭskiĭ satellitnyĭ tsentr instituta mikroélementov IuNESKO;
Laboratoriia vychislitel'noĭ i sistemnoĭ biologii VTs RAN im. A.A. Dorodnitsyna

Stel'mashuk E.V.

NTs nevrologii RAMN

Alexandrova O.P.

Neurology Research Center, Russian Academy of Sciences, Moscow

Pronin A.V.

Ivanovo State Medical Academy, Ivanovo

Gogoleva I.V.

Ivanovskaia gosudarstvennaia meditsinskaia akademiia, Ivanovo

Khaspekov L.G.

All-Russian Research Institute of Physiology, Biochemistry and Food of Animals, Kaluga Region, Borovsk, Russia

A study of the neuroprotective effect of mexidol on the cell model of glutamate stress

Authors:

Gromova O.A., Torshin I.Iu., Stel'mashuk E.V., Alexandrova O.P., Pronin A.V., Gogoleva I.V., Khaspekov L.G.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2017;117(12): 71‑77

DOI: 10.17116/jnevro201711712171-77

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Table of contents

A STUDY OF THE NEUROPROTECTIVE EFFECT OF MEXIDOL ON THE CELL MODEL OF GLUTAMATE STRESS
A STUDY OF THE NEUROPROTECTIVE EFFECT OF MEXIDOL ON THE CELL MODEL OF GLUTAMATE STRESS

To cite this article:

Gromova OA, Torshin IIu, Stel'mashuk EV, Alexandrova OP, Pronin AV, Gogoleva IV, Khaspekov LG. A study of the neuroprotective effect of mexidol on the cell model of glutamate stress. S.S. Korsakov Journal of Neurology and Psychiatry. 2017;117(12):71‑77. (In Russ.)
https://doi.org/10.17116/jnevro201711712171-77

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова (S.S. Korsakov Journal of Neurology and Psychiatry)
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Abstract:

Objective. To study a neuroprotective effect of mexidol on the cell model of glutamate stress. Material and methods. Cytological studies of an effect of glutamate stress on cerebellar granule cells were carried out. Results. Mexidol increased neuronal survival after the addition of glutamate by 8—10% (p<0.05). The effect of mexidol was more pronounced at the stage of neuron culture growth (5 days), cell survivability increased on average by 20%. Conclusion. The results of the study confirmed the neuroprotective effect of mexidol in the neuronal culture in glutamate toxicity model.

Keywords:

stress
excitotoxicity
glutamate
mexidol

Authors:

Gromova O.A.

Rossiĭskiĭ satellitnyĭ tsentr instituta mikroélementov IuNESKO;
Laboratoriia vychislitel'noĭ i sistemnoĭ biologii VTs RAN im. A.A. Dorodnitsyna;
kafedra farmakologii i klinicheskoĭ farmakologii Ivanovskoĭ gosudarstvennoĭ meditsinskoĭ akademii

Torshin I.Iu.

Rossiĭskiĭ satellitnyĭ tsentr instituta mikroélementov IuNESKO;
Laboratoriia vychislitel'noĭ i sistemnoĭ biologii VTs RAN im. A.A. Dorodnitsyna

Stel'mashuk E.V.

NTs nevrologii RAMN

Alexandrova O.P.

Neurology Research Center, Russian Academy of Sciences, Moscow

Pronin A.V.

Ivanovo State Medical Academy, Ivanovo

Gogoleva I.V.

Ivanovskaia gosudarstvennaia meditsinskaia akademiia, Ivanovo

Khaspekov L.G.

All-Russian Research Institute of Physiology, Biochemistry and Food of Animals, Kaluga Region, Borovsk, Russia

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