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Burchakov D.I.

Endocrinology Research Center, Ministry of Health of the Russian Federation, Moscow, Russia

Maĭorov A.Iu.

FGBU "ndokrinologicheskiĭ nauchnyĭ tsentr" Minzdrava RF, Moskva

Intermittent hypoxia due to sleep apnea syndrome in patients with type 2 diabetes mellitus

Authors:

Burchakov D.I., Maĭorov A.Iu.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2017;117(10): 16‑21

DOI: 10.17116/jnevro201711710116-21

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INTERMITTENT HYPOXIA DUE TO SLEEP APNEA SYNDROME IN PATIENTS WITH TYPE 2 DIABETES MELLITUS
INTERMITTENT HYPOXIA DUE TO SLEEP APNEA SYNDROME IN PATIENTS WITH TYPE 2 DIABETES MELLITUS

To cite this article:

Burchakov DI, Maĭorov AIu. Intermittent hypoxia due to sleep apnea syndrome in patients with type 2 diabetes mellitus. S.S. Korsakov Journal of Neurology and Psychiatry. 2017;117(10):16‑21. (In Russ.)
https://doi.org/10.17116/jnevro201711710116-21

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова (S.S. Korsakov Journal of Neurology and Psychiatry)
МСФ на ЯМ
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Abstract:

Objectives. To evaluate the possible association between intermittent hypoxia (IH) and HbA1c in patients with insufficient control type of 2 diabetes mellitus (T2DM). Material and methods. In this cross-sectional study 183 patients with HbAc1≥7% underwent three-channel overnight monitoring (ApneaLink) and completed Berlin Questionnaire, Epworth Sleepiness Scale and Pittsburgh Sleep Quality Index. Patients were divided in two groups, based on the cut-off value of oxygen desaturation index≥15. Results and conclusion. There were 79 (43%) patients with intermittent hypoxia, which was associated with poorer glycaemic control, defined as HbA1c>8.7% (sample median) in the univariate analysis and after adjustment for body mass index OR 2,40 (CI 1.21—4.95, p=0.021). Neither of three questionnaires yielded satisfactory results as a screening method in patients with T2DM. There is a need to implement instrumental screening of sleep-disordered breathing in this population and to study the effects of CPAP-therapy on glycaemic control and carbohydrate metabolism.

Keywords:

obstructive sleep apnea syndrome
type 2 diabetes mellitus
intermittent hypoxia

Authors:

Burchakov D.I.

Endocrinology Research Center, Ministry of Health of the Russian Federation, Moscow, Russia

Maĭorov A.Iu.

FGBU "ndokrinologicheskiĭ nauchnyĭ tsentr" Minzdrava RF, Moskva

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