Intermittent hypoxia due to sleep apnea syndrome in patients with type 2 diabetes mellitus

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Objectives. To evaluate the possible association between intermittent hypoxia (IH) and HbA1c in patients with insufficient control type of 2 diabetes mellitus (T2DM). Material and methods. In this cross-sectional study 183 patients with HbAc1≥7% underwent three-channel overnight monitoring (ApneaLink) and completed Berlin Questionnaire, Epworth Sleepiness Scale and Pittsburgh Sleep Quality Index. Patients were divided in two groups, based on the cut-off value of oxygen desaturation index≥15. Results and conclusion. There were 79 (43%) patients with intermittent hypoxia, which was associated with poorer glycaemic control, defined as HbA1c>8.7% (sample median) in the univariate analysis and after adjustment for body mass index OR 2,40 (CI 1.21—4.95, p=0.021). Neither of three questionnaires yielded satisfactory results as a screening method in patients with T2DM. There is a need to implement instrumental screening of sleep-disordered breathing in this population and to study the effects of CPAP-therapy on glycaemic control and carbohydrate metabolism.

Keywords:

obstructive sleep apnea syndrome

type 2 diabetes mellitus

intermittent hypoxia

Authors:

Burchakov D.I.

Endocrinology Research Center, Ministry of Health of the Russian Federation, Moscow, Russia

Maĭorov A.Iu.

FGBU "ndokrinologicheskiĭ nauchnyĭ tsentr" Minzdrava RF, Moskva

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