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Avedisova A.S.

Serbsky Federal Medical Research Center of Psychiatry and Narcology

The relationship between schizophrenia and epilepsy: the history and current state of the problem

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Avedisova A.S.

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To cite this article:

Avedisova AS. The relationship between schizophrenia and epilepsy: the history and current state of the problem. S.S. Korsakov Journal of Neurology and Psychiatry. 2016;116(9):126‑132. (In Russ.)
https://doi.org/10.17116/jnevro201611691126-132

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References:

  1. Pavlov IP. Psihopatologija i psihiatrija. Izbrannye proizvedenija. M. 1949. (In Russ.).
  2. Stacenko NP, Kovalenko VL. K voprosu o shizojepilepticheskih processah. Jepilepsija. M. 1970;6:106-112. (In Russ.).
  3. Streljuhin AK, Shherbakova NI. K voprosu o kombinacii shizofreniii i jepilepsii. Sbornik nauchnyh trudov Rjazanskogo medicinskogo instituta im. akad. I.P. Pavlova. Rjazan'. 1957;3:132-138. (In Russ.).
  4. Klinicheskaja psihiatrija. Pod red. Grule G, Junga R, Majer-Grossa V, Mjullera M. M. 1967. (In Russ.).
  5. Huber G, Gross G. The bridges between Neurology and Psychiatry. Neurol Croat. 2003:52(suppl 2):65-77.
  6. Landolt H. Some clinical electroencephalographical correlations in epileptic psychoses (twilight states). Electroencephalogr Clin Neurophysiol. 1953;5:121.
  7. Restak R. Complex Partial Seizures: Present Diagnostic Challenge. Psychiatric Times. 1995.
  8. Blumer D, Herzog AG, Himmelhoch J, Salgueiro CA, Ling FW. To what extent do premenstrual and interictal dysphoric disorder overlap? Significance for therapy. J Affect Disord. 1998;48(2-3):215-225.  doi:10.1016/s0165-0327(97)00173-0
  9. Rohlin LL. Sovremennoe sostojanie problemy otnoshenija jepilepsii i shizofrenii. Materialy 5-go Vsesojuznogo s#ezda nevropatologov i psihiatrov. M. 1969;2:71-73. (In Russ.).
  10. Pjatnickaja IN. Klinicheskaja narkologija. L. 1975. (In Russ.).
  11. Favorina VN. O shizofrenopodobnyh hronicheskih jepilepticheskih psihozah. Zhurnal nevropatologii i psihiatrii im. S.S. Korsakova. 1968;68:11:1656-1662. (In Russ.).
  12. Rukovodstvo po psihiatrii. Pod red. Snezhnevskogo AV. M. 1983. (In Russ.).
  13. Shtenberg JeJa. Novye zarubezhnye issledovanija techenija i ishodov shizofrenii. Zhurnal nevropatologii i psihiatrii im. S.S. Korsakova. 1978;78:135-151. (In Russ.).
  14. Rukovodstvo po psihiatrii. Pod red. Tiganova AS. M.: Medicina; 1999. (In Russ.).
  15. Mecov PG, Dvirskij AE. Kliniko-geneticheskie i nozologicheskie aspekty sochetanija shizofrenii i jepilepsii. Teoret i klin problemy sovremennoj psihiatrii i narkologii. Materialy mezhdunarodnogo simpoziuma. M. 1986;156-159. (In Russ.).
  16. Boldyrev AI. Jepilepsija u vzroslyh, hronicheskie shizofrenopodobnye psihozy pri jepilepsii. 1971. (In Russ.).
  17. Gejer TA. K voprosu o differencial'noj diagnostike mezhdu shizofreniej i organicheskim zabolevaniem v tesnom smysle slova. V kn.: Trudy psihiatricheskoj kliniki. 1929;3:217-230. (In Russ.).
  18. Lobova LP. Shizo-jepilepticheskij sindrom pri travmaticheskom porazhenii mozga. Trudy Central'nogo instituta psihiatrii NKZ RSFSR. T.1. M. 1940;64-77. (In Russ.).
  19. Gibbs FA, Gibbs EL. Atlas of electroencephalography. Addison-Wesley Press; Cambridge, MA: 1952.
  20. Matsuura M, Oana Y, Kato M, Kawana A, Kan R, Kubota H, Nakano T, Hara T, Horikawa N. A multicenter study on the prevalence of psychiatric disorders among new referrals for epilepsy in Japan. Epilepsia. 2003;44(1):107-114. doi:10.1046/j.1528-1157.2003.25202.x
  21. Bruens JH. Psychoses in epilepsy. Psychiatr Neurol Neurochir. 1971;74(2):175-192.
  22. Adachi N, Onuma T, Nishiwaki S, Murauchi S, Akanuma N, Ishida S, Takei N. Inter-ictal and post-ictal psychoses in frontal lobe epilepsy: a retrospective comparison with psychoses in temporal lobe epilepsy. Seizure. 2000;9:328-335.  doi:10.1053/seiz.2000.0413
  23. Cascella NG, Schretlen DJ, Sawa A. Schizophrenia and epilepsy: is there a shared susceptibility? Neurosci Res. 2009;63(4):227-235.  doi:10.1016/j.neures.2009.01.002
  24. Slater E, Beard AW, Glithero E. The schizophrenialike psychoses of epilepsy. Br J Psychiatry. 1963;109:95-150.
  25. Mendez MF, Grau R, Doss RC, Taylor JL Schizophrenia in epilepsy: seizure and psychosis variables. Neurology. 1993;43(6):1073-1077. doi: 10.1212/WNL.43.6.1073
  26. Perez MM, Trimble MR. Epileptic psychosis--diagnostic comparison with process schizophrenia. Br J Psychiatry. 1980;137:245-249.  doi: 10.1192/bjp.137.3.245
  27. Matsuura M, Adachi N, Oana Y, Okubo Y, Kato M, Nakano T, Takei N A polydiagnostic and dimensional comparison of epileptic psychoses and schizophrenia spectrum disorders. Schizophr Res. 2004;69(2-3):189-201.  doi: 10.1016/s0920-9964(02)00492-9
  28. Lindsay J, Ounsted C, Richards P. Long-term outcome in children with temporal lobe seizures. III: Psychiatric aspects in childhood and adult life. Dev Med Child Neurol. 1979;21(5):630-636.  doi: 10.1111/j.1469-8749.1979.tb01677.x
  29. Adachi N, Matsuura M, Hara T, Oana Y, Okubo Y, Kato M, Onuma T. Psychoses and epilepsy: are interictal and postictal psychoses distinct clinical entities? Epilepsia 2002;43:1574-1582. doi: 10.1046/j.1528-1157.2002.22402.x
  30. Stefansson SB, Olafsson E, Hauser WA. Psychiatric morbidity in epilepsy: a case controlled study of adults receiving disability benefits. J Neurol Neurosurg Psychiatry. 1998;64(2):238-241.  doi: 10.1136/jnnp.64.2.238
  31. Gudmundsson G. Epilepsy in Iceland. A clinical and epidemiological investigation. Acta Neurol Scand. 1966;43(suppl 25):1-124.
  32. Gelisse P, Samuelian JC, Genton P. Is schizophrenia a risk factor for epilepsy or acute symptomatic seizures? Epilepsia. 1999;40(11):1566-1571. doi: 10.1111/j.1528-1157.1999.tb02041.x
  33. Mäkikyrö T, Karvonen JT, Hakko H, Nieminen P, Joukamaa M, Isohanni M, Jones P, Järvelin MR. Comorbidity of hospital-treated psychiatric and physical disorders with special reference to schizophrenia: a 28-year follow-up of the 1966 northern Finland general population birth cohort. Public Health. 1998;112(4):221-228.  doi: 10.1038/sj.ph.1900455
  34. Cascella NG, Schretlen DJ, Sawa A. Schizophrenia and epilepsy: is there a shared susceptibility? Neurosci Res. 2009;63(4):227-235.  doi: 10.1016/j.neures.2009.01.002
  35. Usjukina MV, Kornilova SV, Shamanaev AS, Shahbazi TA. Hronicheskie shizofrenopodobnye psihozy pri jepilepsii. Zhurnal nevrologii i psihiatrii im. S.S. Korsakova. 2009;8:16-20. (In Russ.).
  36. Kalinin VV. Jepilepticheskie psihozy. Voprosy fenomenologii, sistematiki, patogeneza i terapii. Psihiatrija i psihofarmakoterapija. 2008;10:3. (In Russ.).
  37. Sosjukalo OD. Klinicheskie osobennosti shizofrenii u bol'nyh s ostatochnymi javlenijami mozgovyh travm i infekcij. Po nabljudenijam detskoj kliniki: Dis. ... kand. med. nauk. M. 1963. (In Russ.).
  38. Suhareva GE. Klinicheskie lekcii po psihiatrii detskogo vozrasta. T. 1. M.: Medgiz; 1955. (In Russ.).
  39. Jepileptologija detskogo vozrasta. Rukovodstvo dlja vrachej. Pod red. Petruhina AS. M.: Medicina; 2000. (In Russ.).
  40. Kissin MJa. Klinicheskaja jepileptologija. 2011. (In Russ.).
  41. Vrono MSh, Levina AL. O sochetanii shizofrenicheskih i sudorozhnyh projavlenij u detej. Zhurnal nevropatologii i psihiatrii im. S.S. Korsakova. 1984;10:1547-1550. (In Russ.).
  42. Zigler E. Familial mental retardation: a continuing dilemma. Science. 1967;155(3760):292-298.  doi:10.1126/science.155.3760.292
  43. Lubovskij VI. Zaderzhka psihicheskogo razvitija. Spec psihologija. Pod red. Lubovskogo VI. M.: Akademija; 2003. (In Russ.).
  44. Levy HB. Minimal brain dysfunction/specific learning disability: a clinical approach for the primary physician. South Med J. 1976;69(5):642-653.  doi: 10.1097/00007611-197605000-00047
  45. Gusev UI, Geht AB, Guljaeva AV. Jepileptologija v medicine HHI veka. Pod red. Guseva EI, Geht AB. M. 2009. (In Russ.).
  46. Huber G. Psychiatriе Lehrbuch fur Studium und Weiterbildung. Schattauer. 2004;780.
  47. Berezovskaja MA, Loginov IP. Shizofrenija i mozgovaja disfunkcija. Nevrologija i psihiatrija. 2011;1:58-63. (In Russ.).
  48. Smirnov VK. Nekotorye osobennosti mikrocirkuljacii u bol'nyh paranoidnoj shizofreniej: Dis. ... kand. med. nauk. M. 1970. (In Russ.).
  49. Mendelevich DM. Verbal'nyj galljucinoz. Kazan': Izdatel'stvo Kazanskogo universiteta. 1980. (In Russ.).
  50. Vejn AM. Patogenez cerebral'nyh paroksizmal'nyh sostojanij. Plenum Vsesojuznogo obshhestva nevropatologov i nauchnogo soveta po nevrologii. Materialy. Kiev. 1991;12. (In Russ.).
  51. Karlov VA. Definicii i rubrifikacii paroksizmal'nyh sostojanij v nevrologii. Plenum pravlenija Vsesojuznogo obshhestva nevropatologov i nauchnogo soveta po nevrologii: Materialy (19—21 ijunja, 1991). Kiev. 1991. (In Russ.).
  52. Chikovani GO. Osobennosti jendogennyh psihicheskih zabolevanij s paroksizmal'nopodobnymi rasstrojstvami. Zhurnal nevropatologii i psihiatrii im. S.S. Korsakova. 1997;97:5:18-21. (In Russ.).
  53. Goddard GV, McIntyre DC, Leech CK. A permanent change in brain function resulting from daily electrical stimulation. Exp Neurol. 1969;25:295-330.  doi: 10.1016/0014-4886(69)90128-9
  54. Kalynchuk L.E. Long-term amygdala kindling in rats as a model for the study of interictal emotionality in temporal lobe epilepsy. Neuroscience and Biobehavioral Reviews. 2000;24: 691-704.  doi: 10.1016/s0149-7634(00)00031-2
  55. Jingyi Ma, L. Stan Leung. Schizophrenia-like behavioral changes after partial hippocampal kindling. Brain Research. 2004;997:111-118.  doi: 10.1016/j.brainres.2003.11.004
  56. Yu-Tzu Chang Pei-Chun Chen, I-Ju Tsai, Fung-Chang Sung, Zheng-Nan Chin, Huang-Tsung Kuo, Chang-Hai Tsai, I-Ching Chou. Bidirectional relation between schizophrenia and epilepsy: A population-based retrospective cohort study. Epilepsia. 2011;52(11):2036-2042. doi: 10.1111/j.1528-1167.2011.03268.x
  57. Wotton CJ, Goldacre MJ. Coexistence of schizophrenia and epilepsy: Record-linkage studies. Epilepsia. 53:4:71-74.  doi: 10.1111/j.1528-1167.2011.03390.x
  58. Clancy MJ, Clarke MC, Connor DJ, Cannon M, Cotter DR. The prevalence of psychosis in epilepsy; a systematic review and meta-analysis. BMC Psychiatry. 2014;14:75.  doi: 10.1186/1471-244x-14-75
  59. Matsuura M, Adachi N, Oana Y, Okubo Y, Kato M, Nakano T, Takei N. A polydiagnostic and dimensional comparison of epileptic psychoses and schizophrenia spectrum disorders. Schizophr Res. 2004;69(2-3):189-201.  doi: 10.1016/s0920-9964(02)00492-9
  60. Sachdev P. Schizophrenia-like psychosis and epilepsy: The status of the association. Am J Psychiatry. 1998;155:325-336.  doi: 10.1176/ajp.155.3.325
  61. Qin P, Xu H, Laursen TM, Vestergaard M, Mortensen PB. Risk for schizophrenia and schizophrenia-like psychosis among patients with epilepsy: Population based cohort study. BMJ. 2005;331:23.  doi: 10.1136/bmj.38488.462037.8f
  62. Nathaniel-James DA1, Brown RG, Maier M, Mellers J, Toone B, Ron MA. Cognitive abnormalities in schizophrenia and schizophrenia-like psychosis of epilepsy. Nathaniel-James DA1, Brown RG, Maier M, Mellers J, Toone B, Ron MA. J Neuropsychiatry Clin Neurosci. 2004;16(4):472-479.  doi: 10.1176/jnp.16.4.472
  63. Stevens JR. Epilepsy and psychosis: neuropathological studies of six cases, in Aspects of Epilepsy and Psychiatry. Edited by Trimble MR, Bolwig TG. New York, John Wiley & Sons. 1986;117-146.  doi: 10.1017/s003329170001206x
  64. Bruton CJ, Stevens JR, Frith CD. Epilepsy, psychosis, and schizophrenia: Clinical and neuropathologic correlations. Neurology. 1994;44:34-42.  doi: 10.1212/wnl.44.1.34
  65. Barr WB, Ashtari M, Bilder RM, Degreef G, Lieberman JA. Brain morphometric comparison of first-episode schizophrenia and temporal lobe epilepsy. Br J Psychiatry. 1997;170:515-519.  doi: 10.1016/0920-9964(93)90394-x
  66. Babb TL, Brown WJ. Neuronal, dendritic, and vascular profiles of human temporal lobe epilepsy correlated with cellular physiology in vivo. Adv Neurol. 1986;949-966.
  67. Weinberger DR, Lipska BK. Cortical maldevelopment, anti-psychotic drugs, and schizophrenia: a search for common ground. Schizophr Res. 1995;16:87-110.  doi: 10.1016/0920-9964(95)00013-c
  68. Akbarian S, Bunney JE Jr, Potkin SG, Wigal SB, Hagman JO, Sandman CA, Jones EG. Altered distribution of nicotinamide-adenine dinucleotide phosphate-diaphorase cells in frontal lobe of schizophrenia implies disturbance of cortical development. Arch Gen Psychiatry. 1993;50:169-177.  doi: 10.1001/archpsyc.1993.01820150007001
  69. Stevens JR. Psychiatric consequences of temporal lobectomy for intractable seizures: a 20—30 year follow-up of 14 cases. Psychol Med. 1990;20:529-545.  doi: 10.1017/s0033291700017049
  70. Luhmann HJ, Raabe K, Qu M, Zilles K. Characterization of neuronal migration disorders in neocortical structures: extracellular in vitro recordings. European Journal of Neuroscience. 1998;10:3085-3094; Neuropsychiatry Clin Neurosci. 2004;16(4):472-479.  doi: 10.1046/j.1460-9568.1998.00311.x
  71. Clarke MC, Tanskanen A, Huttunen MO, Clancy M, Cotter DR, Ca M. Evidence for Shared Susceptibility to Epilepsy and Psychosis: A Population-Based Family Study. Biol psychiatry. 2012;71:836-839.  doi: 10.1016/j.biopsych.2012.01.011
  72. Jablensky A. Subtyping schizophrenia: implications for genetic research. Molecular Psychiatry. 2006;11:815-836.  doi: 10.1038/sj.mp.4001857
  73. Kalkman HO. Alterations in the expression of neuronal chloride transporters may contribute to schizophrenia. Prog Neuropsychopharmacol Biol Psychiatry. 2011;3:5:410-414.  doi: 10.1016/j.pnpbp.2011.01.004
  74. Girirajan S, Eichler EE. Phenotypic variability and genetic susceptibility to genomic disorders. Hum Mol Genet. 2010:19:176-187.  doi: 10.1093/hmg/ddq366
  75. Walsh CA, Engle EC. Allelic diversity in human developmental neurogenetics: Insights into biology and disease. Neuron. 2010;68:245-253.  doi: 10.1016/j.neuron.2010.09.042
  76. Kalkman HO. Alterations in the expression of neuronal chloride transporters may contribute to schizophrenia. Prog Neuropsychopharmacol Biol Psychiatry. 2011:35:410-414.  doi: 10.1016/j.pnpbp.2011.01.004
  77. Sipos A, Rasmussen F, Harrison G, Tynelius P, Lewis G, Leon DA, Gunnell D. Paternal age and schizophrenia: A population based cohort study. BMJ. 2004;329:1070. doi: 10.1136/bmj.38243.672396.55
  78. Vestergaard M, Mork A, Madsen KM, Olsen J. Paternal age and epilepsy in the offspring. Eur J Epidemiol. 2005;20:1003-1005. doi: 10.1007/s10654-005-4250-2
  79. Torrey E. Are we overestimating the genetic contribution to schizophrenia? Schizophr Bull. 1992;18:159-170.  doi: 10.1093/schbul/18.2.159
  80. Engel J, Pedley T, Aicardi J, editors. Epilepsy: A Comprehensive Textbook, 2nd ed. Philadelphia: Wolters Kluwer Health/Lippincott Williams and Wilkins. 2007.
  81. Ramalingam A, Zhou XG, Fiedler SD, Brawner SJ, Joyce JM, Liu HY, Yu S. 16p13.11 duplication is a risk factor for a wide spectrum of neuropsychiatric disorders. J Hum Genet. 2011;56:541-544.  doi: 10.1038/jhg.2011.42
  82. Cascella NG, Schretlen DJ, Sawa A. Schizophrenia and epilepsy: is there a shared susceptibility? Neurosci Res. 2009;63(4):227-235.  doi: 10.1016/j.neures.2009.01.002

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