The association between the GRIN2B gene and verbal fluency and impairment of abstract thinking in schizophrenia

Alfimova M.V.

Nauchnyĭ tsentr psikhicheskogo zdorov'ia RAMN

Golimbet V.E.

Nauchnyĭ tsentr psikhicheskogo zdorov'ia RAMN, Moskva

Korovaĭtseva G.I.

Nauchnyĭ tsentr psikhicheskogo zdorovia RAMN, Moskva

Abramova L.I.

Nauchnyĭ tsentr psikhicheskogo zdorov'ia RAMN, Moskva

Lezheĭko T.V.

Nauchnyĭ tsentr psikhicheskogo zdorov'ia RAMN, Moskva

Aksenova E.V.

Tsentr semeĭnoĭ meditsiny "Zdravitsa", Novosibirsk

The association between the GRIN2B gene and verbal fluency and impairment of abstract thinking in schizophrenia

Authors:

Alfimova M.V., Golimbet V.E., Korovaĭtseva G.I., Abramova L.I., Lezheĭko T.V., Aksenova E.V.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2016;116(4): 42‑46

DOI: 10.17116/jnevro20161164142-46

Read: 1075 times

Download PDF (RU)

Contact the author

Table of contents

To cite this article:

Alfimova MV, Golimbet VE, Korovaĭtseva GI, Abramova LI, Lezheĭko TV, Aksenova EV. The association between the GRIN2B gene and verbal fluency and impairment of abstract thinking in schizophrenia. S.S. Korsakov Journal of Neurology and Psychiatry. 2016;116(4):42‑46. (In Russ.)
https://doi.org/10.17116/jnevro20161164142-46

Подписка 2025-2 (S.S. Korsakov Journal of Neurology and Psychiatry)

Использование инфографики авторами научных работ

Close metadata

Recommended articles:

Controversial issues of diagnosis and theoretical concepts of schizophrenia in childhood. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(7):17-24

Psychological concepts — design of clinical models of schizophrenia. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(7):25-31

Pharmacotherapy of schizophrenia: clinical and some age-related aspects. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(7):41-50

Clinical systematics of chronic delusional psychoses in schizophrenia and schizophrenia-spectrum pathology. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(7):65-74

Prolonged and chronic endogenous manic and manic-delusional states (psychopathology, typology, dynamics, clinic). S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(7):75-81

Melatonergic antidepressant agomelatine: augmentation of antipsychotic drugs in treatment of post-schizophrenic depression. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(8):5-12

Metabolic syndrome in clinical psychiatric practice. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(8):13-20

Polymorphic variants in the cluster of genes encoding trace amine receptors and cognitive functioning in patients with schizophrenia spectrum disorders and healthy controls. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(9):122-128

The relationship between inflammatory markers, fatigue, and effort-based decision-making in patients at clinical high risk for psychosis. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(10):85-91

The role of immuno-inflammatory factors in the development of negative symptoms in schizophrenia. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(11):42-48

Objective. To search for the association between the GRIN2B gene and signs of thought and speech disorders which may be the result of decreased accessibility to the mental lexicon. Material and methods. The association between the GRIN2B polymorphism rs7301328 with semantic verbal fluency and five symptoms of thought and speech disorders, as assessed with the PANSS, was studied in 552 patients with schizophrenia-spectrum disorders. Results and conclusion. There was the association of the GRIN2B gene with verbal fluency and the PANSS item «Difficulty in Abstract Thinking». The association was not modified by verbal fluency. The results suggest that the GRIN2B gene may modify the linguistic processes involved in the retrieval of information from the mental lexicon on the basis of semantic traits and, moreover, contribute to the variability of clinical symptoms of impairment of abstract thinking in patients with schizophrenia. The heterozygous genotype may be protective against the development of thought and speech disorders.

Keywords:

semantic verbal fluency

PANSS

schizophrenia

GRIN2B

thought disorder

Authors:

Alfimova M.V.

Nauchnyĭ tsentr psikhicheskogo zdorov'ia RAMN

Golimbet V.E.

Nauchnyĭ tsentr psikhicheskogo zdorov'ia RAMN, Moskva

Korovaĭtseva G.I.

Nauchnyĭ tsentr psikhicheskogo zdorovia RAMN, Moskva

Abramova L.I.

Nauchnyĭ tsentr psikhicheskogo zdorov'ia RAMN, Moskva

Lezheĭko T.V.

Nauchnyĭ tsentr psikhicheskogo zdorov'ia RAMN, Moskva

Aksenova E.V.

Tsentr semeĭnoĭ meditsiny "Zdravitsa", Novosibirsk

List of references:

Klushnik T.P., Brusov O.S., Burbaeva G. Sh., Kolyaskina G.I. Modern view on the basic pathogenetic hypotheses of schizophrenia. Psikhiatriya. 2010; 1(43):7-13. (In Russ)
Adler C, Goldberg T, Malhotra A, Pickar D, Breier A. Effects of Ketamine on Thought Disorder, Working Memory, and Semantic Memory in Healthy Volunteers. Biological Psychiatry. 1998;43(11):811-816. doi:10.1016/s0006-3223(97)00556-8.
Adler C, Malhotra A, Elman I et al. Comparison of Ketamine-Induced Thought Disorder in Healthy Volunteers and Thought Disorder in Schizophrenia. AJP. 1999;156(10):1646-1649. doi:10.1176/ajp.156.10.1646.
Krystal J, Perry E, Gueorguieva R et al. Comparative and Interactive Human Psychopharmacologic Effects of Ketamine and Amphetamine. Arch Gen Psychiatry. 2005;62(9):985. doi:10.1001/archpsyc.62.9.985.
Nagels A, Kirner-Veselinovic A, Wiese R, Paulus F, Kircher T, Krach S. Effects of ketamine-induced psychopathological symptoms on continuous overt rhyme fluency. European Archives of Psychiatry and Clinical Neuroscience. 2011;262(5):403-414. doi:10.1007/s00406-011-0281-8.
Covington M, Riedel W, Brown C et al. Does ketamine mimic aspects of schizophrenic speech?. Journal of Psychopharmacology. 2007;21(3):338-346. doi:10.1177/0269881107077729.
Levy D, Coleman M, Sung H et al. The genetic basis of thought disorder and language and communication disturbances in schizophrenia. Journal of Neurolinguistics. 2010;23(3):176-192. doi:10.1016/j.jneuroling.2009.08.003.
Yang Y, Li W, Zhang H et al. Association Study of N-Methyl-D-Aspartate Receptor Subunit 2B (GRIN2B) Polymorphisms and Schizophrenia Symptoms in the Han Chinese Population. PLoS ONE. 2015;10(5):e0125925. doi:10.1371/journal.pone.0125925.
Ohtsuki T, Sakurai K, Dou H, Toru M, Yamakawa-Kobayashi K, Arinami T. Mutation analysis of the NMDAR2B (GRIN2B) gene in schizophrenia. Molecular Psychiatry. 2001;6(2):211-216. doi:10.1038/sj.mp.4000808.
Li D, He L. Association study between the NMDA receptor 2B subunit gene (GRIN2B) and schizophrenia: A HuGE review and meta-analysis. Genet Med. 2007;9(1):4-8. doi:10.1097/01.gim.0000250507.96760.4b.
Gareeva A, Zakirov D, Khusnutdinova E. Association polymorphic variants of GRIN2B gene with paranoid schizophrenia and response to common neuroleptics in Russians and Tatars from Bashkortostan Republic. Russian Journal of Genetics. 2013;49(9):962-968. doi:10.1134/S1022795413080024. ·
Weickert C, Fung S, Catts V et al. Molecular evidence of N-methyl-D-aspartate receptor hypofunction in schizophrenia. Molecular Psychiatry. 2012;18(11):1185-1192. doi:10.1038/mp.2012.137.
Radanovic M, Sousa R, Valiengo L, Gattaz W, Forlenza O. Formal Thought Disorder and language impairment in schizophrenia. Arq Neuropsiquiatr. 2013;71(1):55-60. doi:10.1590/s0004-282x2012005000015.
Allen H, Liddle P, Frith C. Negative features, retrieval processes and verbal fluency in schizophrenia. The British Journal of Psychiatry. 1993;163(6):769-775. doi:10.1192/bjp.163.6.769.
Joyce E, Collinson S, Crichton P. Verbal fluency in schizophrenia: relationship with executive function, semantic memory and clinical alogia. Psychological Medicine. 1996;26(01):39. doi:10.1017/s0033291700033705.
Goldberg T, Aloia M, Gourovitch M, Missar D, Pickar D, Weinberger D. Cognitive Substrates of Thought Disorder, I: The Semantic System. AJP. 1998;155(12):1671-1676. doi:10.1176/ajp.155.12.1671.
Benjamini Y, Hochberg Y. On the Adaptive Control of the False Discovery Rate in Multiple Testing With Independent Statistics. Journal of Educational and Behavioral Statistics. 2000;25(1):60-83. doi:10.3102/10769986025001060.
Alfimova M. Semantic verbal fluency: normative data and task performance in a schizophrenic sample. Sotsial'naya i klinicheskaya psikhiatriya. 2010;20(3):20-25. (In Russ)
Mori F, Ribolsi M, Kusayanagi H et al. Genetic variants of the NMDA receptor influence cortical excitability and plasticity in humans. Journal of Neurophysiology. 2011;106(4):1637-1643. doi:10.1152/jn.00318.2011.
Shao Z, Janse E, Visser K, Meyer A. What do verbal fluency tasks measure? Predictors of verbal fluency performance in older adults. Frontiers in Psychology. 2014;5. doi:10.3389/fpsyg.2014.00772.
Stolwyk R, Bannirchelvam B, Kraan C, Simpson K. The cognitive abilities associated with verbal fluency task performance differ across fluency variants and age groups in healthy young and old adults.Journal of Clinical and Experimental Neuropsychology. 2014;37(1):70-83. doi:10.1080/13803395.2014.988125.
Qin S, Zhao X, Pan Y et al. An association study of the N-methyl-D-aspartate receptor NR1 subunit gene (GRIN1) and NR2B subunit gene (GRIN2B) in schizophrenia with universal DNA microarray. Eur J Hum Genet. 2005;13(7):807-814. doi:10.1038/sj.ejhg.5201418.
Nicodemus K, Elvevåg B, Foltz P, Rosenstein M, Diaz-Asper C, Weinberger D. Category fluency, latent semantic analysis and schizophrenia: a candidate gene approach. Cortex. 2014;55:182-191. doi:10.1016/j.cortex.2013.12.004.
Cuyàs E, Verdejo-García A, Fagundo A et al. The Influence of Genetic and Environmental Factors among MDMA Users in Cognitive Performance. PLoS ONE. 2011;6(11):e27206. doi:10.1371/journal.pone.0027206.
Ocklenburg S, Arning L, Hahn C et al. Variation in the NMDA receptor 2B subunit gene GRIN2B is associated with differential language lateralization. Behavioural Brain Research. 2011;225(1):284-289. doi:10.1016/j.bbr.2011.07.042.
Ludwig K, Roeske D, Herms S et al. Variation in GRIN2B contributes to weak performance in verbal short-term memory in children with dyslexia. Am J Med Genet. 2009;9999B:n/a-n/a. doi:10.1002/ajmg.b.31007.
Mascheretti S, Facoetti A, Giorda R et al. GRIN2B mediates susceptibility to intelligence quotient and cognitive impairments in developmental dyslexia. Psychiatric Genetics. 2015;25(1):9-20. doi:10.1097/ypg.0000000000000068.
de Quervain D, Papassotiropoulos A. Identification of a genetic cluster influencing memory performance and hippocampal activity in humans. Proceedings of the National Academy of Sciences. 2006;103(11):4270-4274. doi:10.1073/pnas.0510212103.
Jablensky A, Morar B, Wiltshire S et al. Polymorphisms associated with normal memory variation also affect memory impairment in schizophrenia. Genes, Brain and Behavior. 2011;10(4):410-417. doi:10.1111/j.1601-183x.2011.00679.x.
Greenwood T, Light G, Swerdlow N, Radant A, Braff D. Association Analysis of 94 Candidate Genes and Schizophrenia-Related Endophenotypes. PLoS ONE. 2012;7(1):e29630. doi:10.1371/journal.pone.0029630.
Nagels A, Kirner-Veselinovic A, Krach S, Kircher T. Neural correlates of S-ketamine induced psychosis during overt continuous verbal fluency. NeuroImage. 2011;54(2):1307-1314. doi:10.1016/j.neuroimage.2010.08.021.
Kircher T, Leube D, Erb M, Grodd W, Rapp A. Neural correlates of metaphor processing in schizophrenia. Neuroimage. 2007;34(1):281-289. doi:10.1016/j.neuroimage.2006.08.044.
Breitenstein C, Jansen A, Deppe M et al. Hippocampus activity differentiates good from poor learners of a novel lexicon. NeuroImage. 2005;25(3):958-968. doi:10.1016/j.neuroimage.2004.12.019.
Glikmann-Johnston Y, Oren N, Hendler T, Shapira-Lichter I. Distinct functional connectivity of the hippocampus during semantic and phonemic fluency. Neuropsychologia. 2015;69:39-49. doi:10.1016/j.neuropsychologia.2015.01.031.
Kircher T, Whitney C, Krings T, Huber W, Weis S. Hippocampal dysfunction during free word association in male patients with schizophrenia. Schizophrenia Research. 2008;101(1-3):242-255. doi:10.1016/j.schres.2008.02.003.

Close metadata