The association between the GRIN2B gene and verbal fluency and impairment of abstract thinking in schizophrenia

Alfimova M.V.; Golimbet V.E.; Korovaĭtseva G.I.; Abramova L.I.; Lezheĭko T.V.; Aksenova E.V.

doi:https://doi.org/10.17116/jnevro20161164142-46

Alfimova M.V.

Nauchnyĭ tsentr psikhicheskogo zdorov'ia RAMN

Golimbet V.E.

Nauchnyĭ tsentr psikhicheskogo zdorov'ia RAMN, Moskva

Korovaĭtseva G.I.

Nauchnyĭ tsentr psikhicheskogo zdorovia RAMN, Moskva

Abramova L.I.

Nauchnyĭ tsentr psikhicheskogo zdorov'ia RAMN, Moskva

Lezheĭko T.V.

Nauchnyĭ tsentr psikhicheskogo zdorov'ia RAMN, Moskva

Aksenova E.V.

Tsentr semeĭnoĭ meditsiny "Zdravitsa", Novosibirsk

The association between the GRIN2B gene and verbal fluency and impairment of abstract thinking in schizophrenia

Authors:

Alfimova M.V., Golimbet V.E., Korovaĭtseva G.I., Abramova L.I., Lezheĭko T.V., Aksenova E.V.

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Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2016;116(4): 42‑46

DOI: 10.17116/jnevro20161164142-46

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To cite this article:

Alfimova MV, Golimbet VE, Korovaĭtseva GI, Abramova LI, Lezheĭko TV, Aksenova EV. The association between the GRIN2B gene and verbal fluency and impairment of abstract thinking in schizophrenia. S.S. Korsakov Journal of Neurology and Psychiatry. 2016;116(4):42‑46. (In Russ.)
https://doi.org/10.17116/jnevro20161164142-46

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова (S.S. Korsakov Journal of Neurology and Psychiatry)

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Abstract:

Objective. To search for the association between the GRIN2B gene and signs of thought and speech disorders which may be the result of decreased accessibility to the mental lexicon. Material and methods. The association between the GRIN2B polymorphism rs7301328 with semantic verbal fluency and five symptoms of thought and speech disorders, as assessed with the PANSS, was studied in 552 patients with schizophrenia-spectrum disorders. Results and conclusion. There was the association of the GRIN2B gene with verbal fluency and the PANSS item «Difficulty in Abstract Thinking». The association was not modified by verbal fluency. The results suggest that the GRIN2B gene may modify the linguistic processes involved in the retrieval of information from the mental lexicon on the basis of semantic traits and, moreover, contribute to the variability of clinical symptoms of impairment of abstract thinking in patients with schizophrenia. The heterozygous genotype may be protective against the development of thought and speech disorders.

Keywords:

semantic verbal fluency

PANSS

schizophrenia

GRIN2B

thought disorder

Authors:

Alfimova M.V.

Nauchnyĭ tsentr psikhicheskogo zdorov'ia RAMN

Golimbet V.E.

Nauchnyĭ tsentr psikhicheskogo zdorov'ia RAMN, Moskva

Korovaĭtseva G.I.

Nauchnyĭ tsentr psikhicheskogo zdorovia RAMN, Moskva

Abramova L.I.

Nauchnyĭ tsentr psikhicheskogo zdorov'ia RAMN, Moskva

Lezheĭko T.V.

Nauchnyĭ tsentr psikhicheskogo zdorov'ia RAMN, Moskva

Aksenova E.V.

Tsentr semeĭnoĭ meditsiny "Zdravitsa", Novosibirsk

Close metadata

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