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Zavadenko N.N.

Kafedra nevrologii i neĭrokhirurgii pediatricheskogo fakulteta Rossiĭskogo gosudarstvennogo meditsinskogo universiteta, Moskva

Kholin A.A.

Kafedra nervnykh bolezneĭ pediatricheskogo fakul'teta s kursom fakul'teta usovershenstvovaniia vracheĭ Rossiĭskogo gosudarstvennogo meditsinskogo universiteta, Moskva

Zavadenko A.N.

Kafedra neonatologii FUV, NIL profilaktiki i lecheniia postgipoksicheskikh sostoianiĭ u novorozhdennykh GBOU VPO "Rossiĭskiĭ natsional'nyĭ issledovatel'skiĭ meditsinskiĭ universitet im. N.I. Pirogova" Minzdrava RF

Shadrova A.A.

Pirogov Russian National Research Medical University, Ministry of Heath of Russian Federation, Moscow

Orlova K.A.

Pirogov Russian National Research Medical University, Ministry of Heath of Russian Federation, Moscow

Neurodevelopmental disorders in children with epilepsy

Authors:

Zavadenko N.N., Kholin A.A., Zavadenko A.N., Shadrova A.A., Orlova K.A.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2016;116(3): 88‑95

DOI: 10.17116/jnevro20161163188-95

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Table of contents

NEURODEVELOPMENTAL DISORDERS IN CHILDREN WITH EPILEPSY
NEURODEVELOPMENTAL DISORDERS IN CHILDREN WITH EPILEPSY

To cite this article:

Zavadenko NN, Kholin AA, Zavadenko AN, Shadrova AA, Orlova KA. Neurodevelopmental disorders in children with epilepsy. S.S. Korsakov Journal of Neurology and Psychiatry. 2016;116(3):88‑95. (In Russ.)
https://doi.org/10.17116/jnevro20161163188-95

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова (S.S. Korsakov Journal of Neurology and Psychiatry)
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Abstract:

Neurodevelopmental disorders, including intellectual disability, autistic-spectrum disorders, speech disorders, attention deficit hyperactivity disorder (ADHD), learning disabilities, are more prevalent in children with epilepsy compared with the general population. Marked developmental delay and regression of acquired skills are characteristic of epileptic encephalopathies. Conditions, in which neurodevelopmental disorders are associated with the marked epileptiform EEG activity, while clinical epileptic seizures are absent, represent a serious problem. The authors consider the features of epilepsy with electrical status epilepticus during slow-wave sleep, pseudo-Lennox syndrome, Landau-Kleffner syndrome, children autistic epileptiform regression, autosomal-dominant rolandic epilepsy with verbal dispraxy and a combination of epilepsy and subclinical epileptiform EEG activity with developmental dysphasia and ADHD. In addition to the optimization of basic treatment with antiepileptic drugs (AEDs), nootropic drugs which do not increase epileptiform activity (hopantenic acid), are recommended.

Keywords:

epilepsy
children
adolescents
developmental disorders
epileptic encephalopathies
developmental dysphasia
ADHD
hopantenic acid

Authors:

Zavadenko N.N.

Kafedra nevrologii i neĭrokhirurgii pediatricheskogo fakulteta Rossiĭskogo gosudarstvennogo meditsinskogo universiteta, Moskva

Kholin A.A.

Kafedra nervnykh bolezneĭ pediatricheskogo fakul'teta s kursom fakul'teta usovershenstvovaniia vracheĭ Rossiĭskogo gosudarstvennogo meditsinskogo universiteta, Moskva

Zavadenko A.N.

Kafedra neonatologii FUV, NIL profilaktiki i lecheniia postgipoksicheskikh sostoianiĭ u novorozhdennykh GBOU VPO "Rossiĭskiĭ natsional'nyĭ issledovatel'skiĭ meditsinskiĭ universitet im. N.I. Pirogova" Minzdrava RF

Shadrova A.A.

Pirogov Russian National Research Medical University, Ministry of Heath of Russian Federation, Moscow

Orlova K.A.

Pirogov Russian National Research Medical University, Ministry of Heath of Russian Federation, Moscow

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