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Vorobeva O.V.

Chuvash state university named after I.N. Ulyanov

Repina V.V.

Sechenov First Moscow State Medical University

An open comparative observational study of the efficacy and safety of adaptol in anxiety-asthenic disorders in patients with chronic cerebral ischemia

Authors:

Vorobeva O.V., Repina V.V.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2016;116(3): 20‑24

DOI: 10.17116/jnevro20161163120-24

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AN OPEN COMPARATIVE OBSERVATIONAL STUDY OF THE EFFICACY AND SAFETY OF ADAPTOL IN ANXIETY-ASTHENIC DISORDERS IN PATIENTS WITH CHRONIC CEREBRAL ISCHEMIA
AN OPEN COMPARATIVE OBSERVATIONAL STUDY OF THE EFFICACY AND SAFETY OF ADAPTOL IN ANXIETY-ASTHENIC DISORDERS IN PATIENTS WITH CHRONIC CEREBRAL ISCHEMIA

To cite this article:

Vorobeva OV, Repina VV. An open comparative observational study of the efficacy and safety of adaptol in anxiety-asthenic disorders in patients with chronic cerebral ischemia. S.S. Korsakov Journal of Neurology and Psychiatry. 2016;116(3):20‑24. (In Russ.)
https://doi.org/10.17116/jnevro20161163120-24

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова (S.S. Korsakov Journal of Neurology and Psychiatry)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

Objective. To assess the efficacy and safety of adaptol in anxiety-asthenic disorders in patients with chronic cerebral ischemia (CCI).

Material and methods. Forty-nine patients with CCI and comorbid anxiety-asthenic disorder were randomized to standard treatment group (20 patients) and main group which consisted of 29 patients treated with adaptol (500 mg 2 times daily for 6 weeks) in addition to standard treatment. The efficacy of treatment was assessed with HADS-A, HADS-D, FAS and SF-36. Physical fatigue was evaluated using cycle ergometry test.

Results. After 6 weeks, anxiety symptoms were stopped in the most of the patients of the main group (72.4%). The threshold during cycle ergometry was higher in the patients of the main group compared to the comparison group (132.2 vs 114.0 VT, respectively) and the patients experienced less fatigue after the test. Quality-of-life was improved by >10% in patients treated with adaptol and did not changed in the patients of the comparison group.

Conclusion. The addition of adaptol to standard treatment of patients with CCI allows to stop symptoms of anxiety, increase the tolerance to load and improve quality-of-life.

Keywords:

chronic cerebral ischemia
anxiety disorder
fatigue syndrome
tolerance to physical load
quality-of-life
adaptol

Authors:

Vorobeva O.V.

Chuvash state university named after I.N. Ulyanov

Repina V.V.

Sechenov First Moscow State Medical University

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References:

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