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Esin O.R.

Kazan (Volga region) Federal University;
Clinic of Otorhinolaryngology

Khayrullin I.Kh.

Kazan (Volga region) Federal University

Esin R.G.

Kazan State Medical Academy — Branch of the Russian Medical Academy of Continuing Professional Education;
Kazan (Volga Region) Federal University

Tokareva N.V.

Kazan Federal University

Tension type headache: GABA-ergic drug anvifen efficacy

Authors:

Esin O.R., Khayrullin I.Kh., Esin R.G., Tokareva N.V.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2016;116(2): 58‑61

DOI: 10.17116/jnevro20161162158-61

Read: 6756 times

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Table of contents

TENSION TYPE HEADACHE: GABA-ERGIC DRUG ANVIFEN EFFICACY
TENSION TYPE HEADACHE: GABA-ERGIC DRUG ANVIFEN EFFICACY

To cite this article:

Esin OR, Khayrullin IKh, Esin RG, Tokareva NV. Tension type headache: GABA-ergic drug anvifen efficacy. S.S. Korsakov Journal of Neurology and Psychiatry. 2016;116(2):58‑61. (In Russ.)
https://doi.org/10.17116/jnevro20161162158-61

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова (S.S. Korsakov Journal of Neurology and Psychiatry)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

OBJECTIVE

To assess the efficacy of aminophenylbutyric acid (anvifen), a synthetic GABA-receptor agonist, in the treatment of adult patients with tension type headache (TTH).

MATERIAL AND METHODS

Eighty-seven patients with episodic TTH (ETTH) and 30 patients with chronic TTH (CTTH) were examined. The area under the headache curve, sleep quality, the Hospital Anxiety and Depression Scale (HADS) scores and stress resistance measured by an original questionnaire were evaluated.

RESULTS

Anvifen in dose of 250 mg TID during 3 weeks had a positive effect on all parameters studied, excluding the area under the headache curve in CTTH. Similar results were demonstrated after the subsequent course of treatment for 3 weeks.

CONCLUSION

Anvifen was highly effective in ETTH but less effective in CTTH. A combination of anvifen with antidepressants can be recommended for patients with CTTH.

Keywords:

headache
headache
tension type headache
tension type headache
treatment
treatment
aminophenylbutyric acid
aminophenylbutyric acid
anvifen
anvifen
headache
headache
tension type headache
tension type headache
treatment
treatment
aminophenylbutyric acid
aminophenylbutyric acid
anvifen
anvifen

Authors:

Esin O.R.

Kazan (Volga region) Federal University;
Clinic of Otorhinolaryngology

Khayrullin I.Kh.

Kazan (Volga region) Federal University

Esin R.G.

Kazan State Medical Academy — Branch of the Russian Medical Academy of Continuing Professional Education;
Kazan (Volga Region) Federal University

Tokareva N.V.

Kazan Federal University

Close metadata

References:

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