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Azimova Yu.E.

Pervyĭ MGMU im. I.M. Sechenova

Skorobogatykh K.V.

University Headache Clinic, Moscow, Russia

Sergeev A.V.

Chair of biophysical methods in medicine, Faculty of continuing medical education of the Russian University of Peoples’ Friendship;
G.N. Speransky Children's Clinical Hospital №9

Klimov E.A.

Lomonosov’s Moscow State University, Moscow, Russia

Migraine and depression: efficacy and safety of antidepressant therapy

Authors:

Azimova Yu.E., Skorobogatykh K.V., Sergeev A.V., Klimov E.A.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2016;116(11): 35‑40

DOI: 10.17116/jnevro201611611135-40

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Table of contents

MIGRAINE AND DEPRESSION: EFFICACY AND SAFETY OF ANTIDEPRESSANT THERAPY
MIGRAINE AND DEPRESSION: EFFICACY AND SAFETY OF ANTIDEPRESSANT THERAPY

To cite this article:

Azimova YuE, Skorobogatykh KV, Sergeev AV, Klimov EA. Migraine and depression: efficacy and safety of antidepressant therapy. S.S. Korsakov Journal of Neurology and Psychiatry. 2016;116(11):35‑40. (In Russ.)
https://doi.org/10.17116/jnevro201611611135-40

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова (S.S. Korsakov Journal of Neurology and Psychiatry)
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Использование инфографики авторами научных работ
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Abstract:

Objective. To study an influence of depression on the course of migraine and the efficacy of antidepressants in treatment of depression associated with migraine. Material and methods. The study consisted of 544 patients with migraine including 240 patients with depression. Patients were examined at the first visit, after 6 months (visit 2) and one year (visit 3). Then patients were interviewed by phone once a year (visits 5, 6, 7, 8), they were asked about a number of days with migraine. Patients with depression were treated with antidepressants. Results and сonclusion. Six types of migraine course were determined: persistent episodic migraine, migraine remission, episodic migraine chronification, chronic migraine regress to episodic migraine, persistent chronic migraine, remitted or wavelike chronic migraine. The presence of depression and skin allodynia predicted the development of persistent and remitted chronic migraine. The effect of antidepressants of different groups was noted in treatment of patients with the combination of chronic migraine and depression. The most pronounced effect was observed with tricyclic antidepressants, the smallest one when selective serotonin reuptake inhibitors were used.

Keywords:

migraine
depression
antidepressant
trazodone

Authors:

Azimova Yu.E.

Pervyĭ MGMU im. I.M. Sechenova

Skorobogatykh K.V.

University Headache Clinic, Moscow, Russia

Sergeev A.V.

Chair of biophysical methods in medicine, Faculty of continuing medical education of the Russian University of Peoples’ Friendship;
G.N. Speransky Children's Clinical Hospital №9

Klimov E.A.

Lomonosov’s Moscow State University, Moscow, Russia

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