Objective. To explore the variants of attack-like schizophrenia with mixed depression and comorbid phobic, obsessive-compulsive disorders, pathological bodily sensations. Material and methods. Authors studied 29 patients with attack-like schizophrenia using clinical-anamnestic and psychopathological methods as well as psychometric scales (PANSS, Сalgary scale, social and mental functioning scale). Results. Two main clinical groups of attack-like schizophrenia with mixed depression depending on the age of the active manifestations of the disease (adolescent/youth and adulthood) were identified. In accordance to the criteria for the diagnosis of mixed depression in the diagnostic category «Depressive Disorder» DSM-V, 6 manifestations of mania symptoms in the structure of mixed depression in patients with schizophrenia were determined. Their clinical features and frequency are presented.