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Bakhtiiarova K.Z.

Bashkirskiĭ gosudarstvennyĭ meditsinskiĭ universitet, Ufa

Bragina O.V.

BUZ Voronezhskoĭ oblasti "Voronezhskaia oblastnaia klinicheskaia bol'nitsa #1", Voronezh

Vlasov Ia.V.

Kafedra nevrologii i neĭrokhirurgii Samarskogo gosudarstvennogo meditsinskogo universiteta

Greshnova I.V.

GUZ "Ul'ianovskaia oblastnaia klinicheskaia bol'nitsa", Ul'ianovsk

Evdoshenko E.P.

Sankt-Peterburgskoe GBUZ "Gorodskaia klinicheskaia bol'nitsa #31", Sankt-Peterburgskiĭ gorodskoĭ Tsentr rasseiannogo skleroza i autoimmunnykh zabolevaniĭ, Sankt-Peterburg

Ivanishenkova .I.

МУЗ "Городская клиническая больница скорой медицинской помощи №25", Волгоград

Kairbekova E.I.

Kafedra nevrologii i neĭrokhirurgii Sankt-Peterburgskogo gosudarstvennogo meditsinskogo universiteta im. akad. I.P. Pavlova

Karnaukhova E.N.

BMU "Kurskaia oblastnaia klinicheskaia bol'nitsa", Kursk

Korotkevich N.A.

GBUZ Kemerovskoĭ oblasti "Kemerovskaia oblastnaia klinicheskaia bol'nitsa", Kemerovo

Leliukhina A.V.

GUZ "Penzenskaia oblastnaia klinicheskaia bol'nitsa im. N.N. Burdenko", Kliniko-diagnosticheskiĭ tsentr, Penza

Protasov I.S.

БУЗ Воронежской области "Воронежская городская клиническая больница №7", Воронеж

Rybina E.V.

Nauchno-issledovatel'skiĭ institut akusherstva i ginekologii im. D.O. Otta RAMN, Sankt-Peterburg

Sazhnev A.I.

GBUZ "Tambovskaia oblastnaia klinicheskaia bol'nitsa", Tambov

Skoromets A.A.

Sankt-Peterburgskiĭ gosudarstvennyĭ meditsinskiĭ institut im. akad. I.P. Pavlova

Soldatova O.A.

BUZ Omskoĭ oblasti "Kliniko-diagnosticheskiĭ tsentr", Omsk

Trinitatskiĭ Iu.V.

GBUZ "Rostovskaia oblastnaia klinicheskaia bol'nitsa", Rostov-na-Donu

Fedianin A.S.

Kraevoe BUZ "Kraevaia klinicheskaia bol'nitsa", Barnaul

Chelnokova S.N.

GBUZ "Riazanskaia oblastnaia klinicheskaia bol'nitsa", Riazan'

Shabanova V.D.

GBUZ "Kaliningradskaia oblastnaia klinicheskaia bol'nitsa", Kaliningrad

Sharipova R.R.

Sankt-Peterburgskoe GBUZ "Gorodskaia klinicheskaia bol'nitsa #31", Sankt-Peterburgskiĭ gorodskoĭ Tsentr rasseiannogo skleroza i autoimmunnykh zabolevaniĭ, Sankt-Peterburg

Shchegol'kova E.A.

Sankt-Peterburgskoe GBUZ "Gorodskaia klinicheskaia bol'nitsa #31", Sankt-Peterburgskiĭ gorodskoĭ Tsentr rasseiannogo skleroza i autoimmunnykh zabolevaniĭ, Sankt-Peterburg

Iampol'skaia-Gosteva I.A.

GBUZ "Orenburgskaia oblastnaia klinicheskaia bol'nitsa", Orenburg

Experience of using genfaxon for treating patients with relapsing-remitting multiple sclerosis in the Russian Federation

Authors:

Bakhtiiarova K.Z., Bragina O.V., Vlasov Ia.V., Greshnova I.V., Evdoshenko E.P., Ivanishenkova .I., Kairbekova E.I., Karnaukhova E.N., Korotkevich N.A., Leliukhina A.V., Protasov I.S., Rybina E.V., Sazhnev A.I., Skoromets A.A., Soldatova O.A., Trinitatskiĭ Iu.V., Fedianin A.S., Chelnokova S.N., Shabanova V.D., Sharipova R.R., Shchegol'kova E.A., Iampol'skaia-Gosteva I.A.

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Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2014;114(8): 39‑45

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EXPERIENCE OF USING GENFAXON FOR TREATING PATIENTS WITH RELAPSING-REMITTING MULTIPLE SCLEROSIS IN THE RUSSIAN FEDERATION
EXPERIENCE OF USING GENFAXON FOR TREATING PATIENTS WITH RELAPSING-REMITTING MULTIPLE SCLEROSIS IN THE RUSSIAN FEDERATION

To cite this article:

Bakhtiiarova KZ, Bragina OV, Vlasov IaV, et al. . Experience of using genfaxon for treating patients with relapsing-remitting multiple sclerosis in the Russian Federation. S.S. Korsakov Journal of Neurology and Psychiatry. 2014;114(8):39‑45. (In Russ.)

Подписка 2025-2 (S.S. Korsakov Journal of Neurology and Psychiatry)
 
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Multiple sclerosis (MS) is a chronic autoimmune demyelinating disorder of the central nervous system. Nowadays some disease-modifying drugs (DMD) in the Russian Federation (RF) are biosimilars. Their full spectrum of tolerability and efficacy is to be determined. Here we present results of two retrospective-prospective studies on efficacy and safety of a biosimilar interferon beta-1a (genfaxon) in treatment of MS in the RF. Aims. determination of safety and efficacy profile of genfaxon in a routine neurological practice in the RF. Materials and Methods. Trials were performed in 18 MS centers in the RF. A total of 649 patients aged from 18 to 68 years with the EDSS score no more than 6.0 were treated with genfaxon for 12 months. The first group was comprised of 'naïve' patients without previous history of DMD administration. There were patients in the second group which have already received some of DMD. Statistical analysis was performed with the help of significance criteria (χ-square), t-criteria of Student for analysis of independent samplings. Results. There were no serious adverse events during the period of the study. "Naïve" patients had significantly lower number of adverse events, than patients with previous history of DMD usage. Efficacy results were comparable with results published for the Rebif. Conclusions. Data, received from the studies show equal efficacy and tolerability of genfaxon compared with original DMD Rebif.

Keywords:

multiple sclerosis
interferon beta-1a
genfaxon
tolerability
efficacy

Authors:

Bakhtiiarova K.Z.

Bashkirskiĭ gosudarstvennyĭ meditsinskiĭ universitet, Ufa

Bragina O.V.

BUZ Voronezhskoĭ oblasti "Voronezhskaia oblastnaia klinicheskaia bol'nitsa #1", Voronezh

Vlasov Ia.V.

Kafedra nevrologii i neĭrokhirurgii Samarskogo gosudarstvennogo meditsinskogo universiteta

Greshnova I.V.

GUZ "Ul'ianovskaia oblastnaia klinicheskaia bol'nitsa", Ul'ianovsk

Evdoshenko E.P.

Sankt-Peterburgskoe GBUZ "Gorodskaia klinicheskaia bol'nitsa #31", Sankt-Peterburgskiĭ gorodskoĭ Tsentr rasseiannogo skleroza i autoimmunnykh zabolevaniĭ, Sankt-Peterburg

Ivanishenkova .I.

МУЗ "Городская клиническая больница скорой медицинской помощи №25", Волгоград

Kairbekova E.I.

Kafedra nevrologii i neĭrokhirurgii Sankt-Peterburgskogo gosudarstvennogo meditsinskogo universiteta im. akad. I.P. Pavlova

Karnaukhova E.N.

BMU "Kurskaia oblastnaia klinicheskaia bol'nitsa", Kursk

Korotkevich N.A.

GBUZ Kemerovskoĭ oblasti "Kemerovskaia oblastnaia klinicheskaia bol'nitsa", Kemerovo

Leliukhina A.V.

GUZ "Penzenskaia oblastnaia klinicheskaia bol'nitsa im. N.N. Burdenko", Kliniko-diagnosticheskiĭ tsentr, Penza

Protasov I.S.

БУЗ Воронежской области "Воронежская городская клиническая больница №7", Воронеж

Rybina E.V.

Nauchno-issledovatel'skiĭ institut akusherstva i ginekologii im. D.O. Otta RAMN, Sankt-Peterburg

Sazhnev A.I.

GBUZ "Tambovskaia oblastnaia klinicheskaia bol'nitsa", Tambov

Skoromets A.A.

Sankt-Peterburgskiĭ gosudarstvennyĭ meditsinskiĭ institut im. akad. I.P. Pavlova

Soldatova O.A.

BUZ Omskoĭ oblasti "Kliniko-diagnosticheskiĭ tsentr", Omsk

Trinitatskiĭ Iu.V.

GBUZ "Rostovskaia oblastnaia klinicheskaia bol'nitsa", Rostov-na-Donu

Fedianin A.S.

Kraevoe BUZ "Kraevaia klinicheskaia bol'nitsa", Barnaul

Chelnokova S.N.

GBUZ "Riazanskaia oblastnaia klinicheskaia bol'nitsa", Riazan'

Shabanova V.D.

GBUZ "Kaliningradskaia oblastnaia klinicheskaia bol'nitsa", Kaliningrad

Sharipova R.R.

Sankt-Peterburgskoe GBUZ "Gorodskaia klinicheskaia bol'nitsa #31", Sankt-Peterburgskiĭ gorodskoĭ Tsentr rasseiannogo skleroza i autoimmunnykh zabolevaniĭ, Sankt-Peterburg

Shchegol'kova E.A.

Sankt-Peterburgskoe GBUZ "Gorodskaia klinicheskaia bol'nitsa #31", Sankt-Peterburgskiĭ gorodskoĭ Tsentr rasseiannogo skleroza i autoimmunnykh zabolevaniĭ, Sankt-Peterburg

Iampol'skaia-Gosteva I.A.

GBUZ "Orenburgskaia oblastnaia klinicheskaia bol'nitsa", Orenburg

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