Autoantibodies to α7-subunit of neuronal acetylcholine receptor in children with traumatic brain injury

Sorokina E.G.; Vol'pina O.M.; Semenova Zh.B.; Karaseva O.V.; Koroev D.O.; Kamynina A.V.; Reutov V.P.; Salykina M.A.; Panova A.V.; Goriunova A.V.; Pinelis V.G.; Roshal' L.M.

doi:https://doi.org/

Sorokina E.G.

NII neotlozhnoĭ detskoĭ khirurgii i travmatologii, Nauchnyĭ tsentr zdorov'ia deteĭ RAMN, Institut vyssheĭ nervnoĭ deiatel'nosti i neĭrofiziologii RAN, Moskva;
OOO "Gerofarm", Sankt-Peterburg

Vol'pina O.M.

Semenova Zh.B.

NII neotlozhnoĭ detskoĭ khirurgii i travmatologii, Moskva

Karaseva O.V.

State budgetary healthcare facility «Research Institute of Emergency Pediatric Surgery and Traumatology», Moscow Health Department, Moscow, Russian Federation

Koroev D.O.

Kamynina A.V.

Reutov V.P.

NII neotlozhnoĭ detskoĭ khirurgii i travmatologii, Nauchnyĭ tsentr zdorov'ia deteĭ RAMN, Institut vyssheĭ nervnoĭ deiatel'nosti i neĭrofiziologii RAN, Moskva;
OOO "Gerofarm", Sankt-Peterburg

Salykina M.A.

Panova A.V.

Goriunova A.V.

Pinelis V.G.

NII neotlozhnoĭ detskoĭ khirurgii i travmatologii, Nauchnyĭ tsentr zdorov'ia deteĭ RAMN, Institut vyssheĭ nervnoĭ deiatel'nosti i neĭrofiziologii RAN, Moskva;
OOO "Gerofarm", Sankt-Peterburg

Roshal' L.M.

Nauchno-issledovatel'skiĭ institut neotlozhnoĭ detskoĭ khirurgii i travmatologii, Moskva

Autoantibodies to α7-subunit of neuronal acetylcholine receptor in children with traumatic brain injury

Authors:

Sorokina E.G., Vol'pina O.M., Semenova Zh.B., Karaseva O.V., Koroev D.O., Kamynina A.V., Reutov V.P., Salykina M.A., Panova A.V., Goriunova A.V., Pinelis V.G., Roshal' L.M.

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Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2011;111(4): 56‑60

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To cite this article:

Sorokina EG, Vol'pina OM, Semenova ZhB, et al. . Autoantibodies to α7-subunit of neuronal acetylcholine receptor in children with traumatic brain injury. S.S. Korsakov Journal of Neurology and Psychiatry. 2011;111(4):56‑60. (In Russ.)

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова (S.S. Korsakov Journal of Neurology and Psychiatry)

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Abstract:

An objective of the study was to search for new biologically significant markers of brain damage. Levels of blood serum autoantibodies (aAB) to different fragments of α7-subunit of acetylcholine receptor (ACR) were studied in children with traumatic brain injury of different severity. The more severe was trauma, the higher was the level of aAB to fragments of α7-subunit of ACR in the first week after trauma. The data obtained suggest that α7-subunits of ACR and aAB to them are involved in the pathogenesis of traumatic brain lesions and, probably, play a significant role in the course of post traumatic period.

Keywords:

traumatic brain injury

autoantibodies (aAB) to neuronal acetylcholine receptor (α7-ACR)

Authors:

Sorokina E.G.

NII neotlozhnoĭ detskoĭ khirurgii i travmatologii, Nauchnyĭ tsentr zdorov'ia deteĭ RAMN, Institut vyssheĭ nervnoĭ deiatel'nosti i neĭrofiziologii RAN, Moskva;
OOO "Gerofarm", Sankt-Peterburg

Vol'pina O.M.

Semenova Zh.B.

NII neotlozhnoĭ detskoĭ khirurgii i travmatologii, Moskva

Karaseva O.V.

State budgetary healthcare facility «Research Institute of Emergency Pediatric Surgery and Traumatology», Moscow Health Department, Moscow, Russian Federation

Koroev D.O.

Kamynina A.V.

Reutov V.P.

NII neotlozhnoĭ detskoĭ khirurgii i travmatologii, Nauchnyĭ tsentr zdorov'ia deteĭ RAMN, Institut vyssheĭ nervnoĭ deiatel'nosti i neĭrofiziologii RAN, Moskva;
OOO "Gerofarm", Sankt-Peterburg

Salykina M.A.

Panova A.V.

Goriunova A.V.

Pinelis V.G.

NII neotlozhnoĭ detskoĭ khirurgii i travmatologii, Nauchnyĭ tsentr zdorov'ia deteĭ RAMN, Institut vyssheĭ nervnoĭ deiatel'nosti i neĭrofiziologii RAN, Moskva;
OOO "Gerofarm", Sankt-Peterburg

Roshal' L.M.

Nauchno-issledovatel'skiĭ institut neotlozhnoĭ detskoĭ khirurgii i travmatologii, Moskva

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References:

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