Effect of haloperidol and risperidone on neuromarkers and indices of endothelial dysfunction in patients with acute schizophrenia

Govorin N.V.; Vasil'eva A.I.

doi:https://doi.org/

Govorin N.V.

Vasil'eva A.I.

Effect of haloperidol and risperidone on neuromarkers and indices of endothelial dysfunction in patients with acute schizophrenia

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Govorin N.V., Vasil'eva A.I.

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Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2011;111(3): 54‑57

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Govorin NV, Vasil'eva AI. Effect of haloperidol and risperidone on neuromarkers and indices of endothelial dysfunction in patients with acute schizophrenia. S.S. Korsakov Journal of Neurology and Psychiatry. 2011;111(3):54‑57. (In Russ.)

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова (S.S. Korsakov Journal of Neurology and Psychiatry)

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Abstract:

Effect of haloperidol and risperidone on positive, negative, neurocognitive disorders, biological parameters and neurodestruction-neuroreparation processes have been studied in 23 patients with the first episode of paranoid schizophrenia. Risperidone, along with high therapeutic effect towards positive, negative, neurocognitive disorders, is able to reduce brain neurodestruction markers as well as to improve protective-compensatory processes directed to the neuroplasticity restoration. There were correlations between biological parameters studied: the higher were levels of GFAP and antibodies to NR2 subunit of NMDA receptors, the higher were BDNF and NO values. The association between parameters studied and psychopathological disorders measured with the PANSS has been found in patients treated with risperidone. The mentioned correlations were not observed in patients treated with haloperidol.

Keywords:

schizophrenia

risperidone

haloperidol

GFAP

antibodies to NR2 subunit of NMDA receptors

BDNF

endothelin-1

nitric oxide

Authors:

Govorin N.V.

Vasil'eva A.I.

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References:

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