Clinical features of acute cerebral blood circulation disorders in young patients with non-differential dysplasia of the connective tissue

Close metadata

Recommended articles:

Cerebrolysin as an early add-on to reperfusion therapy: heterogeneous treatment effect analysis in ischemic stroke patients with varying risk of hemorrhagic transformation. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(3-2):55-66

Efficacy of Mexidol in combination with cerebral revascularization in the treatment of ischemic stroke. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(3-2):67-74

Cognitive impairment in cerebrovascular diseases. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(4-2):12-16

Algorithms for the diagnosis and treatment of cognitive impairment and dysphagia in stroke patients. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(4-2):100-107

Brain-derived neurotrophic factor in the acute and early recovery period of ischemic stroke: the role of nocturnal hypoxemia. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(5-2):72-78

Comparison of the effectiveness of non-immunogenic staphylokinase and alteplase for intravenous thrombolysis in ischemic stroke: analysis of hospital registry data. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(7):139-144

Artificial ventilation in patients with stroke: main results of the Russian multicenter observational clinical trial RETAS. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(8-2):5-13

The impact of the impairment of social cognitive functions in acute stage of stroke on its functional outcomes. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(8-2):21-25

Possibilities of mirror therapy in cognitive rehabilitation after stroke. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(8-2):64-71

Dynamics of motor and functional disorders in the early recovery period after ischemic stroke. Problems of Balneology, Physiotherapy and Exercise Therapy. 2024;(5):13-22

One hundred young patients (aged 17-45 years) with acute cerebral blood circulation disorders (ACBCD) have been studied. Phenotypic signs of non-differential dysplasia of the connective tissue (NDDCT) have been found in 50 patients (the main group) and other 50 patients had no clinical signs of NDDCT (the comparison group). Patients underwent a complex clinico-neurological, instrumental and laboratory study. In young patients with NDDCT, transient ischemic attacks were observed in 14%, ischemic strokes in 66%, hemorrhagic strokes in 20%. Risk factors characteristic of young patients with ACBCD have been singled out. The higher content of free oxyproline, the distinct positive dynamics (the reduction of clinical symptoms severity during the acute phase of stroke) and the significantly better restoration of lost functions were observed in patients with NDDCT compared to patients without NDDCT.

Keywords:

stroke

young patients

syndrome of non-differential dysplasia of the connective tissue

Authors:

Pizova N.V.

Kafedra nevrologii i neĭrokhirurgii Iaroslavskoĭ gosudarstvennoĭ meditsinskoĭ akademii

Dmitriev A.N.

Kafedra nevrologii i meditsinskoĭ genetiki s kursom neĭrokhirurgii Iaroslavskoĭ gosudarstvennoĭ meditsinskoĭ akademii

Chizhov P.A.

Tabakov V.A.

Prozorovskaia S.D.

List of references:

Baishtruk M.N. Rasstroistva mozgovogo krovoobrashcheniya v molodom vozraste. Problemy klinicheskoi nevrologii. Vladivostok 1973; 42-47.
Burtsev E.M. Narusheniya mozgovogo krovoobrashcheniya v molodom vozraste. M: Meditsina 1978; 199.
Vakhman I.S., Anishchenko G.Ya. Narusheniya mozgovogo krovoobrashcheniya u lyudei molodogo vozrasta. Vrachebnoe delo 1970; 2: 86-88.
Vereshchagin N.V. Geterogennost' insul'ta: vzglyad s pozitsii klinitsista. Zhurn nevropatol i psikhiat (prilozhenie "Insul't") 2003; 9: 8-9.
Gemorragicheskii insul't. Pod red. V.I. Skvortsovoi, V.V. Krylova. M: GEOTAR-Media 2005; 16-23.
Golovskii B.V., Usol'tseva L.V., Khovaeva Ya.B. i dr. Osobennosti klinicheskogo proyavleniya displazii soedinitel'noi tkani u lits trudosposobnogo vozrasta. Klin med 2002; 12: 39-42.
Gusev A.S., Gusev S.A., Krylov V.V. Genetika vnutricherepnykh anevrizm. Nevrol zhurn 2000; 6: 36-40.
Gusev E.I., Skvortsova V.I., Chekneva N.S. i dr. Lechenie ostrogo mozgovogo insul'ta (diagnosticheskie i terapevticheskie algoritmy). M: Izdatel'stvo RGMU 1997; 3-12.
Deev A.S., Zakharushkina I.V. Prichinnye faktory, techenie i iskhody gemorragicheskogo insul'ta v molodom vozraste. Nevrol zhurn 2001; 5: 15-18.
Zemtsovskii E.V. Soedinitel'notkannye displazii serdtsa. St-Peterburg: Politeks 2000; 115.
Kadurina T.I. Nasledstvennye kollagenopatii (klinika, diagnostika, lechenie, dispanserizatsiya). St-Peterburg: Nevskii dialekt 2002; 271.
Kovalenko P.A., Shmatov V.I., Brovkin S.G. i dr. Diagnostika i lechenie arterial'nykh anevrizm, arteriovenoznykh mal'formatsii sosudov golovnogo mozga v molodom vozraste. Aktual'nye problemy sovremennoi nevrologii, psikhiatrii i neirokhirurgii. St-Peterburg 2003; 315-316.
Koval'chuk V.V., Skoromets A.A. Etiologiya i patogenez, diagnostika i lechenie insul'tov u zhenshchin. Zhurn nevropatol i psikhiat (prilozhenie "Insul't") 2006; 16: 10-17.
Lutskii M.A., Kochukova I.V. Dannye epidemiologicheskogo issledovaniya ostrykh narushenii mozgovogo krovoobrashcheniya u lits molodogo vozrasta v Voronezhskom regione. Zhurn nevropatol i psikhiat (prilozhenie "Insul't") 2007; 333-334.
Mkhitarov M.Kh. K voprosu o mozgovykh krovoizliyaniyakh v molodom vozraste. Azerbaidzh med zhurn 1939; 2: 274-285.
Odinak M.M., Voznyuk I.A., Yanishevskii S.N. Estrogen-progestinovaya terapiya kak faktor riska tromboticheskogo insul'ta u molodykh zhenshchin. Zhurn nevropatol i psikhiat (prilozhenie "Insul't") 2007; 335.
Pugachenko N.V., Petukhova N.O., Berezkina V.I. i dr. Insul'ty u lits molodogo vozrasta. IX Vserossiiskii s''ezd nevrologov: tezisnye doklady. Yaroslavl' 2006; 465.
Tetenyats S.S. Metod opredeleniya svobodnogo oksiprolina v syvorotke krovi. Lab delo 1985; 1: 61-62.
Shiretorova D.Ch. Mozgovoi insul't u lits molodogo vozrasta: Avtoref. dis. … kand. med. nauk. 1971.
Abraham J., Shetty G., Jose C.J. Strokes in the young. Stroke 1971; 2: 258-267.
Adams H.P., Kapelle L.J., Biller J. et al. Ischemic stroke in young adults: experience in 329 patients in the Iowa Registry of Stroke in Young Adults. Arch Neurol 1995; 52: 491-495.
Appelros P., Nydevik I., Seiger A. et al. High incidence rates of stroke in Irebro, Sweden: further support for regional iriciclence differences within Scandinavia. Cerebrovasc Dis 2002; 14: 161-168.
Awada A., Daif A., Obeid T. et al. Nontraumatic cerebral hemorrhage in the young: a study of 107 cases. Cerebrovasc Dis 1998; 7: 200-204.
Banet G.A. Stroke in young adults: a retrospective analysis. J Vase Nurs 1994; 12: 4: 101-105.
Correia M., Silva M.R., Matos I. et al. Prospective community-based study of stroke in Northern Portugal. Incidence and case-fatality in rural and urban population. Stroke 2004; 35: 2048-2053.
Czlonkowska A., Ryglewicz D., Weissbein T. et al. A prospective community-basedstudy of stroke in Warsaw, Poland. Stroke 1994; 25: 547-551.
Ellekjaer H., Holmen J., Indredavik B. et al. Epidemiology of stroke in Innhererred, Norway, 1994 to 1996. Incidence and 30-day case-fatality rate. Stroke 1997; 28: 2180-2184.
Gandolfo C., Croce R. Ischemic stroke in the young adult. Ann Ital Med Int 1996; 11: 1: 33-38.
Ghandehari K., Izadi Moud Z. Incidence and etiology of ischemic stroke in Persian young adults. Acta Neurol Scand 2006; 113: 121-124.
Hoffman M. Intracranial hemorrhage in young people is mostly due to vascular abnormality or drug abuse and mortality rate is low. American Stroke Association International Stroke Conference 2005; 395.
Kolominsky-Rabas P.L., Webere M., Gefeller O. et al. Epidemiology of ischemic stroke subtypes according to TOAST criteria. Inciderice, recurrence, and long-term survival in ischemic stroke subtypes: a population-based study. Stroke 2001; 32: 2735-2740.
Lebedeva E.R., Sakovich V.P., Kotov N.B. et al. Syndrome of systemic connective tissue dysplasia in patients with intracranial aneurysms. Eur J Neurol 2005; 12: 174.
Marini C., Totaro R., De Santis F. et al. Stroke in young adults in the community-based LAquila registry: incidence and prognosis. Stroke 2001; 32: 52-56.
Naess H., Nyland H.I., Thomassen L. et al. Etiology of and risk factors for cerebral infarction in young adults in western Norway: a population-based case-control study. Eur J Neurol 2004; 11: 25.
Rastenyte D., Cepaitis Z., Sarti S. et al. Epidemiology of stroke in Kaunas, Lithuania: first results from the Kaunas Stroke Register. Stroke 1995; 26: 240-244.
Runz-Sandoval J.L., Cant C., Barinagarrementeria F. et al. Intracerebral hemorrhage in young people: analysis of risk factors, location, causes and prognosis. Stroke 1999; 30: 3: 537-541.
Truelsen T., Piechowski-Jozwiak V., Bonita R. et al. Stroke incidence and prevalence in Europe: a review of available data. Eur J Neurol 2006; 13: 581-598.
Vemmos K.N., Bots M.L., Tsibouris P.K. Stroke incidence and case fatality in southern Greece: the Arcadia stroke registry. Stroke 1999; 30: 363-370.
Vibo R., Korv J., Haldre S. et al. First-year results of the third stroke registry in Tartu, Estonia. Cerebrovasc Dis 2004; 18: 227-231.

Close metadata