Effect of therapeutic hypothermia on post-stroke sleep disorders

Torshin D.V.; Shevelev O.A.; Fedin A.I.; Levin M.K.; Petrova M.V.

doi:https://doi.org/10.17116/jnevro202512512294

Torshin D.V.

Federal Research and Clinical Center of Resuscitation and Rehabilitation

ORCID: 0000-0002-0134-5284

Shevelev O.A.

Federal Research and Clinical Center of Resuscitation and Rehabilitation;
Patrice Lumumba Peoples’ Friendship University of Russia

ORCID: 0000-0002-6204-1110

Fedin A.I.

Pirogov Russian National Research Medical University

ORCID: 0000-0003-1794-4414

Levin M.K.

Federal Research and Clinical Center of Resuscitation and Rehabilitation

ORCID: 0009-0008-8631-9149

Petrova M.V.

Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology

ORCID: 0000-0003-4272-0957

Effect of therapeutic hypothermia on post-stroke sleep disorders

Authors:

Torshin D.V., Shevelev O.A., Fedin A.I., Levin M.K., Petrova M.V.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2025;125(12‑2): 94‑99

DOI: 10.17116/jnevro202512512294

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To cite this article:

Torshin DV, Shevelev OA, Fedin AI, Levin MK, Petrova MV. Effect of therapeutic hypothermia on post-stroke sleep disorders. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;125(12‑2):94‑99. (In Russ.)
https://doi.org/10.17116/jnevro202512512294

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова. Спецвыпуски (S.S. Korsakov Journal of Neurology and Psychiatry (special issues))

Использование инфографики авторами научных работ

OBJECTIVE

To study the effect of therapeutic hypothermia on the sleep quality of patients in the early recovery period of ischemic stroke (IS).

MATERIAL AND METHODS

The study included 32 patients in the early recovery period of IS. The test group included 22 patients (10 with IS in the vertebral-basilar system (VBS) and 12 with IS in the carotid system), and the control group included 10 patients (5 with IS in the VBS and 5 with IS in the carotid system). Control group patients received drug therapy, physiotherapy (magnetic therapy and electrotherapy), exercise therapy, and massage. Treatment in the test group also included craniocerebral hypothermia (CCH); 10 daily sessions of 90 min. Non-invasive radiothermometry was used to measure cerebral cortical temperature.

RESULTS

After CCH, the test group showed a statistically significant decrease in cerebral cortical temperature compared to the control group (p<0.015). Of note, the test group showed a statistically significant decrease in cerebral cortical temperature only in patients with IS in the VBS (p<0.001). It was shown that rehabilitation treatment with CCH significantly improved sleep efficiency, increasing the total sleep amount from 263 [101; 401] to 327 [181; 435] minutes, the sleep efficiency index from 51 [18; 72.6] to 62.3 [46; 85.3] %, the N2-stage of sleep from 25.6 [15.7; 36.9] to 29.0 [22; 42.9] %, and reducing the wake time during sleep from 40 [13; 57] to 34.5 [11; 44] % (p<0.05). Improved sleep quality in the test group was observed in patients with IS in the VBS. Sleep efficiency was unchanged in the control group.

CONCLUSION

Thus, the data obtained support the relationship between brain temperature and sleep processes. With a decrease in brain temperature, sleep quality improves.

Keywords:

ischemic stroke

therapeutic hypothermia

sleep efficiency

Authors:

Torshin D.V.

Federal Research and Clinical Center of Resuscitation and Rehabilitation

ORCID: 0000-0002-0134-5284

Shevelev O.A.

Federal Research and Clinical Center of Resuscitation and Rehabilitation;
Patrice Lumumba Peoples’ Friendship University of Russia

ORCID: 0000-0002-6204-1110

Fedin A.I.

Pirogov Russian National Research Medical University

ORCID: 0000-0003-1794-4414

Levin M.K.

Federal Research and Clinical Center of Resuscitation and Rehabilitation

ORCID: 0009-0008-8631-9149

Petrova M.V.

Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology

ORCID: 0000-0003-4272-0957

Received:

13.08.2025

Accepted:

15.09.2025

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