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Katunina E.A.

Federal center of brain research and neurotechnologies;
Pirogov Russian National Research Medical University Moscow, Russi

Shipilova N.N.

Federal center of brain research and neurotechnologies;
Pirogov Russian National Research Medical University Moscow, Russi

Farnieva I.A.

North Caucasian Multidisciplinary Medical Center

Isaeva Z.S.

Pirogov City Clinical Hospital No. 1

Dzugaeva F.K.

North Caucasian Multidisciplinary Medical Center

Belikova L.P.

Pirogov City Clinical Hospital No. 1

Batsoeva D.O.

North Caucasian Multidisciplinary Medical Center

Cognitive impairment in multiple system atrophy — exclusion criteria or an integral part of the clinical picture?

Authors:

Katunina E.A., Shipilova N.N., Farnieva I.A., Isaeva Z.S., Dzugaeva F.K., Belikova L.P., Batsoeva D.O.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2024;124(4‑2): 86‑91

DOI: 10.17116/jnevro202412404286

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To cite this article:

Katunina EA, Shipilova NN, Farnieva IA, Isaeva ZS, Dzugaeva FK, Belikova LP, Batsoeva DO. Cognitive impairment in multiple system atrophy — exclusion criteria or an integral part of the clinical picture?. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;124(4‑2):86‑91. (In Russ.)
https://doi.org/10.17116/jnevro202412404286

Подписка 2025 (S.S. Korsakov Journal of Neurology and Psychiatry (special issues))
 
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Multiple system atrophy (MSA) is a severe, orphan disease characterized by a steady increase in symptoms of parkinsonism, cerebellar disorders, and autonomic failure. In addition to autonomic failure, which is considered the defining symptom of this type of atypical parkinsonism, there are a range of other non-motor clinical manifestations, such as sleep disorders, pain syndrome, anxiety-depressive disorders, cognitive impairment (CI). CI, especially severe CI, has long been considered as a distinctive feature of MCA. Recently, there have been many clinical studies with pathomorphological or neuroimaging confirmation, indicating a high prevalence of cognitive disorders in MCA. In this article, we discuss the pathogenetic mechanisms of the development of MCA and CI in MCA, as well as the range of clinical manifestations of cognitive dysfunction.

Keywords:

multisystem atrophy
cognitive impairment
pathogenesis
dementia

Authors:

Katunina E.A.

Federal center of brain research and neurotechnologies;
Pirogov Russian National Research Medical University Moscow, Russi

Shipilova N.N.

Federal center of brain research and neurotechnologies;
Pirogov Russian National Research Medical University Moscow, Russi

Farnieva I.A.

North Caucasian Multidisciplinary Medical Center

Isaeva Z.S.

Pirogov City Clinical Hospital No. 1

Dzugaeva F.K.

North Caucasian Multidisciplinary Medical Center

Belikova L.P.

Pirogov City Clinical Hospital No. 1

Batsoeva D.O.

North Caucasian Multidisciplinary Medical Center

Received:

15.01.2024

Accepted:

22.01.2024

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