The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Login
EN
+7 (495) 482-4118
+7 (495) 482-0604
+8 800 250-18-12
  • (toll-free number for subscriptions)
    Mon-Fri from 10 a.m. to 6 p.m.

  • © 1998-2025
+7 (495) 482-43-29
EN
All journals
Journal
Year
Year
Search result: 0

Rubina S.S.

Tver State Medical University

Makarova I.I.

Tver State Medical University

Yusufov A.A.

Tver State Medical University

The relationship of vascular complications with cerebrovascular reactivity and endothelial dysfunction in patients with obstructive sleep apnea

Authors:

Rubina S.S., Makarova I.I., Yusufov A.A.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2023;123(5‑2): 82‑88

DOI: 10.17116/jnevro202312305282

Read: 3101 times

Download PDF (RU)
Contact the author
Table of contents

THE RELATIONSHIP OF VASCULAR COMPLICATIONS WITH CEREBROVASCULAR REACTIVITY AND ENDOTHELIAL DYSFUNCTION IN PATIENTS WITH OBSTRUCTIVE SLEEP APNEA
THE RELATIONSHIP OF VASCULAR COMPLICATIONS WITH CEREBROVASCULAR REACTIVITY AND ENDOTHELIAL DYSFUNCTION IN PATIENTS WITH OBSTRUCTIVE SLEEP APNEA

To cite this article:

Rubina SS, Makarova II, Yusufov AA. The relationship of vascular complications with cerebrovascular reactivity and endothelial dysfunction in patients with obstructive sleep apnea. S.S. Korsakov Journal of Neurology and Psychiatry. 2023;123(5‑2):82‑88. (In Russ.)
https://doi.org/10.17116/jnevro202312305282

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова. Спецвыпуски (S.S. Korsakov Journal of Neurology and Psychiatry (special issues))
 
МСФ на ЯМ
Использование инфографики авторами научных работ
Close metadata
Recommended articles:
Anti-aging klotho protein. Asso­ciations with sleep patterns in obstructive sleep apnea: A pilot study. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(5-2):98-102
Sleep diso­rders in patients with Lewy body deme­ntia and Parkinson’s disease. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(4-2):81-87
Inte­rnational multicenter randomized double-blind placebo-controlled study asse­ssing the effi­cacy and safety of sequential therapy with Mexi­dol and Mexi­dol FORTE 250 in patients with chro­nic brain ischemia (MEMO): suba­nalysis in patients with arte­rial hype­rtension. Russian Journal of Preventive Medi­cine. 2024;(10):72-83
Adva­nces in thro­mbectomy in the acute ischemic stroke. Russian Journal of Preventive Medi­cine. 2024;(10):137-143
Reso­lution of the expert council «Possibilities of neuroprotective therapy in patients with arte­rial hype­rtension and cognitive diso­rders». Russian Journal of Preventive Medi­cine. 2024;(11):85-93
Evaluation of the effe­ctiveness of the drug Cortexin in combination with the use of the application Apha­sia.No (Afaziyam.Net) in the correction of speech diso­rders in patients with cere­bral infa­rction. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(11):147-151
Modern aspe­cts of chro­nic cere­bral ischemia pathogenetic therapy. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(12):106-113
The Rela­tionship of obstructive sleep apnea with paro­xysmal atrial fibrillation in women suffered coro­nary heart disease and arte­rial hype­rtension. Russian Journal of Preventive Medi­cine. 2025;(2):61-66
The effect of Mexi­dol on the level of neurogenesis markers in acute cere­brovascular acci­dent in the expe­riment. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(2):107-112
The effe­ctiveness of laser sculpture uvulopalatoplasty in the treatment of a patient with rhonchopathy and severe obstructive sleep apnea syndrome. Clinical case. Russian Bulletin of Otorhinolaryngology. 2025;(1):75-77
Abstract:

OBJECTIVE

To assess the relationship of vascular complications with cerebrovascular reactivity (CVR) and endothelial dysfunction in patients with obstructive sleep apnea (OSA).

MATERIAL AND METHODS

One hundred and twelve patients were examined. The patients were stratified into the main group with moderate and severe OSA and the control group without apnea. All patients underwent anthropometry, polysomnography, transcranial dopplerography and duplex scanning of the brachial artery.

RESULTS

Patients with OSA showed a more frequent decrease in post-occlusive vascular dilatation. The CVR indices in the hypercapnic test in the main group were in the range of 0.91—0.97 and significantly lower after 1 minute on the left, after 5 minutes on both sides and after 10 minutes on the left. A positive correlation during a hypercapnic test between the CVR on the left after 10 minutes and the desaturation index (r=0.287, p=0.021), between the CVR on the left after 5 and 10 minutes and acute cerebrovascular accident (r=0.248, p=0.048 and r=0.285, p=0.022, respectively), as well as a negative correlation between the indicators of the middle cerebral artery and chronic cerebral ischemia were established in patients with apnea.

CONCLUSION

Timely assessment of pathological changes in central and peripheral hemodynamics in patients with OSA will allow diagnosing early signs of vascular complications, which will further improve the personalized strategy for the prevention of stroke and chronic cerebral ischemia.

Keywords:

obstructive sleep apnea
polysomnography
transcranial dopplerography
cerebrovascular reactivity
chronic cerebral ischemia
acute cerebrovascular accident

Authors:

Rubina S.S.

Tver State Medical University

Makarova I.I.

Tver State Medical University

Yusufov A.A.

Tver State Medical University

Received:

13.02.2023

Accepted:

04.03.2023

Close metadata

References:

  1. Buzunov RV, Palman AD, Melnikov AYu, et al. Diagnostics and treatment of obstructive sleep apnea syndrome in adults. Ehffektivnaya farmakoterapiya. Nevrologiya i psikhiatriya. Spetsvypusk «Son i ego rasstroistva». 2018;35:34-45. Accessed February 9,2023. (In Russ.). https://umedp.ru/articles/diagnostika_i_lechenie_sindroma_obstruktivnogo_apnoe_sna_u_vzroslykh_rekomendatsii_rossiyskogo_obshch.html
  2. Rubina SS, Makarova II. Obstructive sleep apnea: a modern view of the problem. Ural’skii Meditsinskii Zhurnal. 2021;20(4):85-92. (In Russ.). https://doi.org/10.52420/2071-5943-2021-20-4-85-92
  3. Tishkevich ES, Kolyadich ZhV. Risk factors for obstructive sleep apnea syndrome. Otorinolaringologiya. Vostochnaya Evropa. 2020;10(2):96-102. (In Russ.).
  4. Gottlieb DJ, Punjabi NM. Diagnosis and Management of Obstructive Sleep Apnea: A Review. JAMA. 2020;323(14):1389-1400. https://doi.org/10.1001/jama.2020.3514
  5. Brown DL, Shafie-Khorassani F, Kim S, et al. Sleep-Disordered Breathing Is Associated with Recurrent Ischemic Stroke. Stroke. 2019;50:571-576.  https://doi.org/10.1161/STROKEAHA.118.023807
  6. Javaheri S, Peker Y, Yaggi HK, Bassetti CLA. Obstructive sleep apnea and stroke: The mechanisms, the randomized trials, and the road ahead. Sleep Med Rev. 2022;61:101568. https://doi.org/10.1016/j.smrv.2021.101568
  7. Yashchenko AV, Kamaev YuO. The risk of developing cognitive impairment in patients with obstructive sleep apnea syndrome. Vestnik psikhofiziologii. 2018;(3):113-128. (In Russ.).
  8. Kemstach VV, Korostovtseva LS, Golovkova-Kucheryavaya MS, et al. Obstructive sleep apnea syndrome and cognitive impairment. Zhurnal Nevrologii i Psikhiatrii im. S.S. Korsakova. 2020;120(1):90-95. (In Russ.). https://doi.org/10.17116/jnevro202012001190
  9. Xiong L, Liu X, Shang T, et al. Impaired cerebral autoregulation: measurement and application to stroke. J Neurol Neurosurg Psychiatry. 2017;88(6):520-531.  https://doi.org/10.1136/jnnp-2016-314385
  10. Patel A, Chong DJ. Obstructive Sleep Apnea: Cognitive Outcomes. Clin Geriatr Med. 2021;37(3):457-467.  https://doi.org/10.1016/j.cger.2021.04.007
  11. Sagaidachny AA. Occlusion test: methods of analysis, reaction mechanisms, prospects for application. Regionarnoe Krovoobrashchenie i Mikrotsirkulyatsiya. 2018;17(3):5-22. (In Russ.). https://doi.org/10.24884/1682-6655-2018-17-3-5-22
  12. Dematteis M, Julien C, Guillermet C, et al. Intermittent hypoxia induces early functional cardiovascular remodeling in mice. Am J Respir Crit Care Med. 2008;177:227-235.  https://doi.org/10.1164/rccm.200702-238OC
  13. Carreras A, Zhang SX, Peris E, et al. Chronic sleep fragmentation induces endothelial dysfunction and structural vascular changes in mice. Sleep. 2014;37:1817-1824. https://doi.org/10.5665/sleep.4178
  14. Agaltsov MV, Drapkina OM. Obstructive sleep apnea and cardiovascular comorbidity: common pathophysiological mechanisms. Ratsional’naya Farmakoterapiya v Kardiologii. 2021;17(4):594-605. (In Russ.). https://doi.org/10.20996/1819-6446-2021-08-05
  15. Galitsyn PV, Litvin AYu, Chazova IE. Obstructive apnea syndrome during sleep and endothelial dysfunction. Kardiologicheskii Vestnik. 2007;2:71-75. (In Russ.).
  16. Hoyos CM, Melehan KL, Liu PY, et al. Does obstructive sleep apnea cause endothelial dysfunction? A critical review of the literature. Sleep Med Rev. 2015;20:15-26.  https://doi.org/10.1016/j.smrv.2014.06.003
  17. Domashenko MA, Chechetkin AO, Suslina ZA. Ultrasound evaluation of endothelial dysfunction in patients in acute period of ischemic stroke. Ul’trazvukovaya i Funktsional’naya Diagnostika. 2007;2:73-81. (In Russ.).
  18. Kawada T. The association between apnoea-hypopnoea index and flow-mediated dilation of brachial artery. Heart. 2014;100(1):81.  https://doi.org/10.1136/heartjnl-2013-304643
  19. Kulikov V.P. [ed.] Ul’trazvukovaya diagnostika sosudistykh zabolevanii. Rukovodstvo dlya vrachei. 2-e izd. 2nd ed. M.: LLC «Firma STROM»; 2011. (In Russ.).
  20. Ripp TM, Rebrova NV. The value of assessing cerebrovascular reactivity in arterial hypertension and comorbid pathology. Arterial’naya gipertenziya. 2021;27(1):51-63. (In Russ.). https://doi.org/10.18705/1607-419X-2021-27-1-51-63
  21. Williams B, Mancia G, Spiering W, et al. 2018 ESC/ESH Guidelines for the management of arterial hypertension. Eur Heart J. 2018;39(33):3021-3104. https://doi.org/10.1093/eurheartj/ehy339
  22. Marincowitz C, Genis A, Goswami N, et al. Vascular endothelial dysfunction in the wake of HIV and ART. FEBS J. 2019;286(7):1256-1270. https://doi.org/10.1111/febs.14657
  23. Kulesh AA, Emelin AYu, Bogolepova AN, et al. Clinical manifestations and issues of diagnosis of chronic cerebrovascular disease [chronic cerebral ischemia] at an early [predemental] stage. Nevrologiya, neiropsikhiatriya, psikhosomatika. 2021;13(1):4-12. (In Russ.). https://doi.org/10.14412/2074-2711-2021-1-4-12
  24. Del Ben M, Fabiani M, Loffredo L, et al. Oxidative stress mediated arterial dysfunction in patients with obstructive sleep apnoea and the effect of continuous positive airway pressure treatment. BMC Pulm Med. 2012;12:36.  https://doi.org/10.1186/1471-2466-12-36
  25. Wang J, Yu W, Gao M, et al. Impact of obstructive sleep apnea syndrome on endothelial function, arterial stiffening, and serum inflammatory markers: an updated meta-analysis and metaregression of 18 studies. J Am Heart Assoc. 2015;4(11):e002454. https://doi.org/10.1161/JAHA.115.002454
  26. Jelic S, Padeletti M, Kawut SM, et al. Inflammation, oxidative stress, and repair capacity of the vascular endothelium in obstructive sleep apnea. Circulation. 2008;117(17): 2270-2278. https://doi.org/10.1161/CIRCULATIONAHA.107.741512
  27. Lloret A, Buj J, Badia MC, et al. Obstructive sleep apnea: arterial oxygen desaturation coincides with increases in systemic oxidative stress markers measured with continuous monitoring. Free Radic Biol Med. 2007;42(6):893-894.  https://doi.org/10.1016/j.freeradbiomed.2006.10.051
  28. Kumar GK, Rai V, Sharma SD, et al. Chronic intermittent hypoxia induces hypoxia-evoked catecholamine efflux in adult rut adrenal medulla via oxidative stress. J Physiol. 2006;575(Pt1):229-239.  https://doi.org/10.1113/jphysiol.2006.112524
  29. Heiser C, Eckert D. Pathophysiology of obstructive sleep apnea. HNO. 2019;67(9):654-662.  https://doi.org/10.1007/s00106-019-0720-9
  30. Lelyuk VG, Lelyuk SE. Ul’trazvukovaya angiologiya. Izdanie vtoroe, dopolnennoe i pererabotannoe. M.: Real time; 2003. (In Russ.).
Contact the author
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.

Email Confirmation

An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

Email Confirmation

Contact us
If you have any questions, complaints or suggestions, please use this feedback form.
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.
Submit Application

You can become an author of one of our magazines, send a request and we will consider it in during the day.

Name
Phone
E-mail
Message
Login
Registration
E-mail
Password
Forgot Password?

Log in to the site using your account in one of the services

Password recovery
E-mail
Login
Register

We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.