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Verbitsky E.V.

Southern Scientific Centre of the Russian Academy of Sciences

Poluektov M.G.

Sechenov First Moscow State Medical University (Sechenov University)

Sleep regulation as a complex process

Authors:

Verbitsky E.V., Poluektov M.G.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2023;123(5‑2): 8‑14

DOI: 10.17116/jnevro20231230528

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Table of contents

SLEEP REGULATION AS A COMPLEX PROCESS
SLEEP REGULATION AS A COMPLEX PROCESS

To cite this article:

Verbitsky EV, Poluektov MG. Sleep regulation as a complex process. S.S. Korsakov Journal of Neurology and Psychiatry. 2023;123(5‑2):8‑14. (In Russ.)
https://doi.org/10.17116/jnevro20231230528

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова. Спецвыпуски (S.S. Korsakov Journal of Neurology and Psychiatry (special issues))
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Использование инфографики авторами научных работ
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Abstract:

A retrospective analysis of views on the regulation of the «sleep-wakefulness» cycle from the reticular theory of sleep to the Saper’s model was carried out. A modified version of the Saper’s trigger made it possible to use the results of a comparative analysis of drugs used in the treatment of sleep disorders to develop new, comprehensive, effective approaches to the pharmacotherapy of the most common sleep disorders. It seems that this approach will be useful in the development of effective pharmacotherapy for sleep disorders.

Keywords:

sleep-wake cycle
sleep
reticular theory of sleep
Saper’s model
mediators and modulators of sleep
Levroso Long

Authors:

Verbitsky E.V.

Southern Scientific Centre of the Russian Academy of Sciences

Poluektov M.G.

Sechenov First Moscow State Medical University (Sechenov University)

Received:

04.04.2023

Accepted:

14.04.2023

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References:

  1. Nauta W. Hypothalamic regulation of sleep in rats: an experimental study. J Neurophys. 1946;9:285-316.  https://doi.org/10.1152/jn.1946.9.4.285
  2. Berger H. Uber das Elektrenkephalogramm des Menschen. Arc Psychiatr Nervenkrank. 1929;87:527-570.  https://doi.org/10.1007/BF01797193
  3. Moruzzi G, Magoun H. Brain stem reticular formation and activation of the EEG. EEG Clin Neurophys. 1949;1:455-473.  https://doi.org/10.1016/0013-4694(49)90219-9
  4. Rechtschaffen A, Kales A. (Eds.) A manual of standardized terminology, techniques and scoring systems for sleep stages of human subjects. Washington D.C.: Public Health Service, U.S. Government Printing Office. 1968.
  5. McCarley R, Hobson J. Neuronal excitability modulation over the sleep cycle: a structural and mathematical model. Science. 1975;4:189(4196):58-60.  https://doi.org/10.1126/science.1135627
  6. Borbeli A. Tajna sna. M.: Znanie. 1989. (In Russ.).
  7. Gusel’nikov VI. Elektrofiziologiya golovnogo mozga. M.: Vysshaya shkola; 1976. (In Russ.).
  8. Magnes J, Moruzzi G, Pompeano O. Synchronization of the EEG produced by low-frequency electrical stimulation of the region of the solitary tract. Arch Ital Biol. 1961;99:33-67. 
  9. Vejn AM. Son — tajny i paradoksy. M.: Ejdos media; 2003. (In Russ.).
  10. Koval’zon VM. Osnovy somnologii. M.: Binom. Laboratoriya znanij; 2011. (In Russ.).
  11. Poluektov MG. Insomniya. In: Somnologiya i medicina sna. Pod red. Poluektova M.G. M.: Medforum; 2016;298-318. (In Russ.).
  12. Milner P. Fiziologicheskaya psixologiya. M.: Mir; 1973. (In Russ.).
  13. Hess W, Koella W, Akert K. Cortical and subcortical recording in natural and artificially induced sleep in cats. EEG and Clin. Neurophys. 1953;5:75-90.  https://doi.org/10.1016/0013-4694(53)90055-8
  14. Denoyer M, Sallanon M, Buda C, et al. Neurotogic lesion of the mesencephalic reticular formation and/or the posterior hypothalamus does not alter waking in cat. Brain Res. 1991;539:287-303.  https://doi.org/10.1016/0006-8993(91)91633-C
  15. Kovalzon V. Ascending reticular activating system of the brain. Transcl Neurosci Clin. 2016;2(4):275-285.  https://doi.org/10.18679/CN11-6030_R.2016.034
  16. Zhuve M. Nauka o sne. Kto poznaet tajnu sna — poznaet tajnu mozga. Pod red. Koval’zona V.M. M.: Izd-vo AST; 2021. (In Russ.).
  17. Saper C, Chou T, Scammell T. The sleep switch: hypothalamic control of sleep and wakefulness. Trends Neurosci. 2001;24(12):726-731.  https://doi.org/10.1016/s0166-2236(00)02002-6
  18. McGinty D, Szymusiak R. Hypothalamic regulations of sleep and arousal. Front Biosci. 2003;8:1074-1083. https://doi.org/10.1196/annals.1417.027
  19. Saper C, Fuller P, Pedersen N, et al. Sleep state switching. Neuron. 2010;68:1023-1042. https://doi.org/10.1016/j.neuron.2010.11.032
  20. Koval’zon VM, Dolgih VV. Regulyaciya cikla bodrstvovanie-son. Nevrologicheskij Zhurnal. 2016;21(6):316-322. (In Russ.). https://doi.org/10.18821/1560-9545-2016-21-6
  21. Bullock L. Sleep Research Timeline: A History of Sleep Research. Sleep Research Timeline. 2022. https://doi.org/10.1016/j.sleh.2018.10.004
  22. Radulovacki M. Adenosine sleep theory: how I postulated it. Neurol Res. 2005;27:137-138.  https://doi.org/10.1179/016164105X21814
  23. Saper C, Fuller P. Wake-sleep circuitry: an overview. Curr Opin Neurobiol. 2017;44:186-192.  https://doi.org/10.1016/j.conb.2017.03.021
  24. Ketut D, Utami I, Lohita P. Classical theory and glutamate’s role in wake-sleep cycle. Int J Med Rev Case Rep. 2022;5(12):11-14.  https://doi.org/10.5455/IJMRCR.ClassicalTheoryandGlutamatesRoleinWake-SleepCycle
  25. Poluektov MG. Primenenie psihotropnyh preparatov pri hronicheskoj insomnii v klinicheskoj praktike. Zhurnal Nevrologii i Psihiatrii im. S.S. Korsakova. 2021;121(4-2):61-67. (In Russ.). https://doi.org/10.17116/jnevro202112104261
  26. Verkhratsky A. A Physiology of neuronal-glial networking. Neurochem Int. 2011;57:332-343.  https://doi.org/10.1016/j.neuint.2010.02.002
  27. Tyurikova O, Shih P, Dembitskaya Y, et al. K+ efflux through postsynaptic NMDA receptors suppresses local astrocytic glutamate uptake. Glia. 2022;70(5):961-974.  https://doi.org/10.1002/glia.24150
  28. Vaidyanathan T, Collard M, Yokoyama S, et al. Cortical astrocytes independently regulate sleep depth and duration via separate GPCR pathways. Neuroscience. 2021;6:114-120.  https://doi.org/10.7554/eLife.63329
  29. Vyazovskiy V, Olcese U, Hanlon E, et al. Local sleep in awake rats. Nature. 2011;472: 443-447.  https://doi.org/10.1038/nature10009
  30. Thomas C, Guillaumin M, McKillop L, et al. Global sleep homeostasis reflects temporally and spatially integrated local cortical neuronal activity. Elife. 2020;9:e54148. https://doi.org/10.7554/elife.54148
  31. Semyanov A. GABA-ergic inhibition in the CNS: Types of GABA receptors and mechanisms of tonic GABA-mediated inhibitory action. Neurophysiology. 2002;34(1):71-80.  https://doi.org/10.1023/A:1020274226515
  32. Strygin KN. Rol’ central’nyh blokatorov gistaminovyh receptorov v lechenii insomnii. Zhurnal Nevrologii i Psihiatrii im. S.S. Korsakova. Specvypusk. 2018;118(4-2):73-82. (In Russ.). https://doi.org//10.17116/jnevro20181184273
  33. Koval’zon VM. Rol’ oreksinergicheskoj sistemy mozga v regulyacii bodrstvovaniya i sna. Effektivnaya Farmakoterapiya. Nevrologiya i Psihiatriya. Specvypusk. 2016;19(2-4):6-14. (In Russ.). https://doi.org/10.17116/jnevro20181184273
  34. Sateia M, Buysse D, Krystal A, et al. Clinical Practice Guideline for the Pharmacologic Treatment of Chronic Insomnia in Adults: An American Academy of Sleep Medicine Clinical Practice Guideline. J Clin Sleep Med. 2017;13(2):307-349.  https://doi.org/10.5664/jcsm.6470
  35. Wade A, Crawford G, Ford I, et al. Prolonged release melatonin in the treatment of primary insomnia: evaluation of the age cut-off for short- and long-term response. Curr Med Res Opin. 2011;27(1):87-98.  https://doi.org/10.1185/03007995.2010.537317
  36. Popova VB, Leykin ZN. Comparative study of the clinical efficacy and safety of the fixed dose combination Levroso Long with Melaxen and Diphenhydramine in patients with drowsiness. Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova. 2023;123(5-2):76–81. (In Russ.). https://doi.org/10.17116/jnevro202312305276
  37. Instructions for medical use of the drug Levroso Long RU: LP-No. (001767) — (RG-RU). (In Russ.).
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