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Nemkova S.A.

Pirogov Russian National Research Medical University

Boldyrev V.G.

Pirogov Russian National Research Medical University

Complex diagnostics and treatment of cognitive dysfunctions in cerebral palsy

Authors:

Nemkova S.A., Boldyrev V.G.

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To cite this article:

Nemkova SA, Boldyrev VG. Complex diagnostics and treatment of cognitive dysfunctions in cerebral palsy. S.S. Korsakov Journal of Neurology and Psychiatry. 2022;122(9‑2):51‑61. (In Russ.)
https://doi.org/10.17116/jnevro202212209251

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References:

  1. Zdravookhranenie v Rossii, 2021. Statisticheskij sbornik. Rosstat. M.; 2021. (In Russ.).
  2. Nemkova SA. Kognitivnye narusheniya pri detskom tserebral’nom paraliche. M.: Triada-X; 2013. (In Russ.).
  3. Nemkova SA. Disorders of mental development in cerebral palsy: comprehensive diagnosis and correction. S.S. Korsakov Journal of Neurology and Psychiatry. 2018;2:105-113. (In Russ.). https://doi.org/10.17116/jnevro201811821105-113
  4. Federal’noe rukovodstvo po detskoj nevrologii. Guzeva VI, ed. M.: IMK; 2016. (In Russ.).
  5. Nemkova SA. Detskij tserebral’nyj paralich: sovremennye tekhnologii v kompleksnoj diagnostike i reabilitatsii kognitivnykh rasstrojstv. M.: Medpraktika-M; 2013. (In Russ.).
  6. Nemkova SA, Maslova OI, Karkashadze GA, et al. Cognitive impairment in children with cerebral palsy (structure, diagnosis, treatment). Pediatricheskaya farmakologiya. 2012;9(3):77-84. (In Russ.). https://doi.org/10.15690/pf.v9i3.327
  7. Kancherla V, Amendah DD, Grosse SD, et al. Medical expenditures attributable to cerebral palsy and intellectual disability among Medicaid-enrolled children. Res Dev Disabil. 2012;33(3):832-840.  https://doi.org/10.1016/j.ridd.2011.12.001
  8. Nemkova SA, Maslova OI, Karkashadze GA, Mamedyarov AM. Psychological aspects of complex medical and social rehabilitation of disabled children with cerebral palsy. Pediatricheskaya farmakologiya. 2013;10(2):107-116. (In Russ.). https://doi.org/10.15690/pf.v10i2.652
  9. Nemkova SA, Maslova OI, Zavadenko NN, Karkashadze GA. Features of diagnosis and rehabilitation of cognitive disorders in children with cerebral palsy. Detskaya i podrostkovaya reabilitatsiya. 2012;1:4-15. (In Russ.).
  10. Nemkova SA, Namazova-Baranova LS, Maslova OI, Zavadenko NN, et al. Detskij tserebral’nyj paralich: diagnostika i korrektsiya kognitivnykh narushenij. M.: Soyuz pediatrov Rossii; 2012. (In Russ.).
  11. Fluss J, Lidzba K. Cognitive and academic profiles in children with cerebral palsy: A narrative review. Ann Phys and Rehab Med. 2020;63(5):447-456.  https://doi.org/10.1016/j.rehab.2020.01.005
  12. Galli J, Ambrosi C, Micheletti S, et al. White matter changes associated with cognitive visual dysfunctions in children with cerebral palsy: A diffusion tensor imaging study. J Neurosci Res. 2018;96:1766-1774. https://doi.org/10.3233/JAD-150306
  13. Laporta-Hoyos O, Pannek K, Ballester-Plane J, et al. White matter integrity in dyskinetic cerebral palsy: Relationship with intelligence quotient and executive function. Neuroimage Clin. 2017;15:789-800.  https://doi.org/10.1016/j.nicl.2017.05.005
  14. Shevell MI, Dagenais L, Hall N, et al. Comorbidities in cerebral palsy and their relationship to neurologic subtype and GMFCS level. Neurology. 2009;72:2090-2096. https://doi.org/10.1212/WNL.0b013e3181aa537b
  15. Ballester-Plane J, Schmidt R, Laporta-Hoyos O, et al. Whole-brain structural connectivity in dyskinetic cerebral palsy and its association with motor and cognitive function. Hum Brain Mapp. 2017;38:4594-4612. https://doi.org/10.1002/hbm.23686
  16. Weierink L, Vermeulen RJ, Boyd RN. Brain structure and executive functions in children with cerebral palsy: a systematic review. Res Dev Disabil. 2013;(34):1678-1688. https://doi.org/10.1016/j.ridd.2013.01.035
  17. Scheck SM, Pannek K, Raffelt DA, et al. Structural connectivity of the anterior cingulate in children with unilateral cerebral palsy due to white matter lesions. Neuroimage Clin. 2015;9:498-505.  https://doi.org/10.1016/j.nicl.2015.09.014
  18. Badalyan LO, Zhurba LT, Timonina OV. Detskij tserebral’nyj paralich. Kiev: Zdorov’e; 1988. (In Russ.).
  19. Semenova KA. Vosstanovitel’noe lechenie detej s perinatal’nym porazheniem nervnoj sistemy i detskim tserebral’nym paralichom. M.: Kodeks; 2007. (In Russ.).
  20. Kalizhnyuk ES. Psikhicheskie narusheniya pri detskikh tserebral’nykh paralichakh. Kiev: Vishcha shkola; 1987. (In Russ.).
  21. Kolker IA. Visual evoked potentials and visual function disorders in children with cerebral palsy. Neirofiziologiya. 2004;36(3):248-255. (In Russ.).
  22. Mamaichuk II. Psikhologiya dizontogeneza i osnovy psikhokorrektsii. SPb: SpbGU; 2001. (In Russ.).
  23. Mastyukova EM. Deti s tserebral’nym paralichom. Spetsial’naya psikhologiya. Lubovsky VI, ed. M. 2003. (In Russ.).
  24. Kolker IA. Hearing function and auditory evoked potentials in children with spastic forms of cerebral palsy. Nejrofiziologiya. 2004;36(4):306-312. (In Russ.).
  25. Pirila S, van der Meere JJ, Rantanen K, et al. Executive functions in youth with spastic cerebral palsy. J Child Neurol. 2011;26(7):817-821.  https://doi.org/10.1177/0883073810392584
  26. Bottcher L, Flachs E, Uldall P. Attentional and executive impairments in children with spastic cerebral palsy. Dev Med Child Neurol. 2010;52(2):42-47.  https://doi.org/10.1111/j.1469-8749.2009.03533.x
  27. Foulder-Hughes LA, Cooke RW. Motor, cognitive, and behavioural disorders in children born very preterm. Dev Med Child Neurol. 2003;45(2):97-103. 
  28. Staudt M, Pavlova M, Bohm S, et al. Pyramidal tract damage correlates with motor dysfunction in bilateral periventricular leukomalacia (PVL) Neuropediatrics. 2003;34:182-188.  https://doi.org/10.1055/s-2003-42206
  29. Bodimeade HL, Whittingham K, Lloyd O, et al. Executive function in children and adolescents with unilateral cerebral palsy. Dev Med Child Neurol. 2013;55(10):926-933.  https://doi.org/10.1111/dmcn.12195
  30. Belmonti V, Berthoz A, Cioni G, et al. Navigation strategies as revealed by error patterns on the Magic Carpet test in children with cerebral palsy. Front Psychol. 2015;6: 880.  https://doi.org/10.3389/fpsyg.2015.00880
  31. Critten V, Messer D, Sheehy K. Delays in the reading and spelling of children with cerebral palsy: Associations with phonological and visual processes. Res Dev Disabil. 2019;85:131-142.  https://doi.org/10.1016/j.ridd.2018.12.001
  32. Carlsson G. Memory for words and drawings in children with hemiplegic cerebral palsy. Scand J Psychol. 1997;38:265-273.  https://doi.org/10.1111/1467-9450.00036
  33. Gagliardi C, Tavano A, Turconi AC, et al. Sequence learning in cerebral palsy. Pediatr Neurol. 2011;44:207-213.  https://doi.org/10.1016/j.pediatrneurol.2010.10.004
  34. Jenks KM, de Moor J, van Lieshout EC. Arithmetic difficulties in children with cerebral palsy are related to executive function and working memory. J Child Psychol Psychiatry. 2009;50:824-833.  https://doi.org/10.1111/j.1469-7610.2008.02031.x
  35. Peeters M, Verhoeven L, de Moor J. Predictors of verbal working memory in children with cerebral palsy. Res Dev Disabil. 2009;30:1502-1511. https://doi.org/10.1016/j.ridd.2009.07.014
  36. Pueyo R, Junque C, Vendrell P. Neuropsychologic differences between bilateral dyskinetic and spastic cerebral palsy. J Child Neurol. 2003;(18):845-850.  https://doi.org/10.1177/088307380301801204
  37. Nordberg A, Dahlgren SC. MiniscalcoStory retelling and language ability in school-aged children with cerebral palsy and speech impairmentInt. J Lang Commun Disord. 2015;50:801-813.  https://doi.org/10.1111/1460-6984.12177
  38. Van Handel M, de Sonneville L, de Vries LS, et al. SwaabSpecific memory impairment following neonatal encephalopathy in term-born children. Dev Neuropsychol. 2012;37:30-50.  https://doi.org/10.1080/87565641.2011.581320
  39. Crespo-Eguilaz N, Dominguez PD, Vaquero M, et al. Developmental amnesia and early brain damage: neuropsychology and neuroimaging. Rev Neurol. 2018;66:83-89. 
  40. Sellier E, Uldall P, Calado E, et al. Epilepsy and cerebral palsy: characteristics and trends in children born in 1976-1998. Eur J Paediatr Neurol. 2012;16:48-55.  https://doi.org/10.1016/j.ejpn.2011.10.003
  41. Van Buuren LM, van der Aa NE, Dekker HC, et al. Cognitive outcome in childhood after unilateral perinatal brain injury. Dev Med Child Neurol. 2013;55(10):934-940.  https://doi.org/10.1111/dmcn.12187
  42. Hoare B, Ditchfield M, Thorley M, et al. Cognition and bimanual performance in children with unilateral cerebral palsy: protocol for a multicentre, cross-sectional study. BMC Neurol. 2018;18:63.  https://doi.org/10.1186/s12883-018-1070-z
  43. Sherwell S, Reid S, Reddihough DS, et al. Measuring intellectual ability in children with cerebral palsy: Can we do better? Res Dev Disabil. 2014;35(10):2558-2567. https://doi.org/10.1016/j.ridd.2014.06.019
  44. Reid SM, Meehan EM, Arnup SJ, et al. Intellectual disability in cerebral palsy: A population-based retrospective study. Dev Med Child Neurol. 2018;60:687-694.  https://doi.org/10.1111/dmcn.13773
  45. Kozyavkin VI. Dynamics of speech disorders in patients with cerebral palsy (cerebral palsy) treated with the help of intensive neurophysiological rehabilitation system. Ukrains’kij visnik psikhonevrologii. 1995;3(2):55-56. (In Russ.).
  46. Panchenko II. Speech disorders in children with cerebral palsy and features of speech therapy work with them. Medical rehabilitation and social adaptation of patients with cerebral palsy. Tashkent: Meditsina; 1979. (In Russ.).
  47. Pahlman M, Gillberg C, Himmelmann K. One-third of school-aged children with cerebral palsy have neuropsychiatric impairments in a population-based study. Acta Paediatr. 2019;108(11):2048-2055. https://doi.org/10.1111/apa.14844
  48. Carcreff L, Fluss J, Allali G, et al. The effects of dual tasks on gait in children with cerebral palsy. Gait Posture. 2019;(70):148-155.  https://doi.org/10.1016/j.gaitpost.2019.02.014
  49. Stadskleiv K. Cognitive functioning in children with cerebral palsy. Developmental Medicine & Child Neurology. 2020;62(3):283-289.  https://doi.org/10.1111/dmcn.14463
  50. Gillies MB, Bowen JR, Patterson JA, et al. Educational outcomes for children with cerebral palsy: A linked data cohort study. Dev Med Child Neurol. 2018;60:397-401.  https://doi.org/10.1111/dmcn.13651
  51. Dahlgren Sandberg A. Reading and spelling abilities in children with severe speech impairments and cerebral palsy at 6, 9, and 12 years of age in relation to cognitive development: a longitudinal study. Dev Med Child Neurol. 2006;48:629-634.  https://doi.org/10.1017/S0012162206001344
  52. Card R, Dodd B. The phonological awareness abilities of children with cerebral palsy who do not speak. Augment Altern Commun. 2006;22:149-159.  https://doi.org/10.1080/07434610500431694
  53. Asbell S, Donders J, Van Tubbergen M, et al. Predictors of reading comprehension in children with cerebral palsy and typically developing children. Child Neuropsychol. 2010;16:313-325.  https://doi.org/10.1080/09297041003733588
  54. Van Rooijen M, Verhoeven L, Steenbergen B. Working memory and fine motor skills predict early numeracy performance of children with cerebral palsy. Child Neuropsychol. 2016;22:735-747.  https://doi.org/10.1080/09297049.2015.1046426
  55. Kim HY. An investigation of the factors affecting handwriting articulation of school aged children with cerebral palsy based on the international classification of functioning, disability and health. J Phys Ther Sci. 2016;28:347-350.  https://doi.org/10.1589/jpts.28.347
  56. Bumin G, Kavak ST. An investigation of the factors affecting handwriting skill in children with hemiplegic cerebral palsy. Disabil Rehabil. 2010;32: 692-703.  https://doi.org/10.3109/09638281003654789
  57. Pagliano E, Fedrizzi E, Erbetta A, et al. Cognitive profiles and visuoperceptual abilities in preterm and term spastic diplegic children with periventricular leukomalacia. J Child Neurol. 2007;22:282-288.  https://doi.org/10.1177/0883073807300529
  58. Di Lieto MC, Brovedani P, Pecini C, et al. Spastic diplegia in preterm-born children: Executive function impairment and neuroanatomical correlates. Res Dev Disabil. 2017;61:116-126.  https://doi.org/10.1016/j.ridd.2016.12.006
  59. Lidzba K, de Haan B, Wilke M, et al. Lesion characteristics driving right-hemispheric language reorganization in congenital left-hemispheric brain damage. Brain Lang. 2017;173:1-9.  https://doi.org/10.1016/j.bandl.2017.04.006
  60. Kitai Y, Haginoya K, Hirai S, et al. Outcome of hemiplegic cerebral palsy born at term depends on its etiology. Brain Dev. 2015;38(3):267-273.  https://doi.org/10.1016/j.braindev.2015.09.007
  61. Woolpert D, Reilly JS. Investigating the extent of neuroplasticity: Writing in children with perinatal stroke. Neuropsychologia. 2016;89:105-118.  https://doi.org/10.1016/j.neuropsychologia.2016.06.005
  62. Reilly JS, Wasserman S, Appelbaum M. Later language development in narratives in children with perinatal stroke. Dev Sci. 2013;16:67-83.  https://doi.org/10.1111/j.1467-7687.2012.01192.x
  63. Frampton I, Yude C, Goodman R. The prevalence and correlates of specific learning difficulties in a representative sample of children with hemiplegia. Br J Educ Psychol. 1998;68:39-51.  https://doi.org/10.1111/j.2044-8279.1998.tb01273.x
  64. Himmelmann K, McManus V, Hagberg G, et al. Dyskinetic cerebral palsy in Europe: trends in prevalence and severity. Arch Dis Child. 2009;94:921-926.  https://doi.org/10.1136/adc.2008.144014
  65. Ballester-Plane J, Laporta-Hoyos O, Macaya A, et al. Cognitive functioning in dyskinetic cerebral palsy: Its relation to motor function, communication and epilepsy. Eur J Paediatr Neurol. 2018;22:102-112.  https://doi.org/10.1016/j.ejpn.2017.10.006
  66. Gosling AS. Recent advances in the neuroimaging and neuropsychology of cerebral palsy. Appl Neuropsychol Child. 2017;6:55-63.  https://doi.org/10.1080/21622965.2015.1074914
  67. Kozhevnikova VT. Sovremennye tekhnologii v kompleksnoj fizicheskoj reabilitatsii bol’nykh detskim tserebral’nym paralichom. M.; 2005. (In Russ.).
  68. Nemkova SA. Cerebral Palsy: early diagnosis and rehabilitation treatment. Lechashchij vrach. 2016;5:24-29. (In Russ.).
  69. Nemkova SA, Zavadenko NN, Shchederkina IO, Popov VE, et al. Modern methods in the complex rehabilitation of children with the consequences of stroke, cerebral palsy and traumatic brain injury. Farmateka. 2015;11(304):37-44. (In Russ.).
  70. Zavadenko NN, Nemkova SA. Narusheniya razvitiya i kognitivnye disfunktsii u detej s zabolevaniyami nervnoj sistemy. M.: MEDpress-inform; 2016. (In Russ.).
  71. Globa OV, Kuzenkova LM, Goryunova AV, Maslova OI. Nootropic drugs — neuropeptides in the treatment of neurological disorders in children. Sovremennye problemy nauki i obrazovaniya. 2008;4:51-52. (In Russ.).
  72. Petrukhin AS, Pylaeva OA. Perspectives of therapy with Cerebrolysin in neurology and its place in clinical practice of pediatric neurology. Russian Journal of Child Neurology. 2012;7(3):27-40. (In Russ.).
  73. Vostrikov VV, Shishlyanikov GZ, Zelentsov KE, et al. Cerebrolysin in practical medicine. Obzory po klinicheskoj farmakologii i lekarstvennoj terapii. 2009;7(4):21-75. (In Russ.).
  74. Medvedev MI, Rogatkin SO, Gorbunov AV, Degtyareva MG, et al. Efficacy of the drug Cerebrolysin in the treatment of perinatal hypoxic-ischemic brain lesions in premature infants. Voprosy prakticheskoj pediatrii. 2009;4(1):82-86. (In Russ.).
  75. Nemchenyuk MA, Dorokhova DV, Kartashova AM, et al. Results of treatment with cerebrolysin in children with organic brain lesions. Nevrologiya i psihiatriya (Kiev). 1971;1:60-63. (In Russ.).
  76. Quandt J, Sommer H. About the problem posed by a protective therapy for high-risk children. Cellulatheraaple and Onco-Biotherapie. 1994;Oct:21-23. 
  77. Quandt J, Walter L. Problems of the effect of Cerebrolysin in the newborn. 2nd Soviet-Austrian symposium. 1975; Dec, 2. 
  78. Sayfutdinova SR. Clinical experience of neuroprotective therapy in periventricular leukomalacia in children. Zhurnal biomediciny i praktiki. 2021;6(1): 58-63. (In Russ.).
  79. Morozova EA. The use of cerebrolysin in pediatric neurology. Trudnyj patsient. 2007;5(10):35-39. (In Russ.).
  80. Zavadenko NN, Kozlova EV. Drug therapy of developmental dysphasia in children with medications. Voprosy prakticheskoj pediatrii. 2013;8(5):24-28. (In Russ.).
  81. Chutko LS, Surushkina SYu, Yakovenko EA, et al. Clinical and electroencephalographic features of specific speech development disorders in children and evaluation of the effectiveness of the use of cerebrolysin. S.S. Korsakov Journal of Neurology and Psychiatry. 2015;7:98-102. (In Russ.). https://doi.org/10.17116/jnevro20151157198-102
  82. Shmonin AA. Modern algorithms of multidisciplinary rehabilitation of patients with cerebral palsy. Effektivnaya farmakoterapiya. 2019;19:44-45. (In Russ.).
  83. Maksimov OG, Lavrik SYu, Domitrak SV. Neuroprotectors in the treatment and rehabilitation of children with cerebral palsy and minimal brain dysfunction. Sibirskij meditsinskij zhurnal. 2009;7:90-92. (In Russ.).
  84. Batysheva TT, Bykova OV, Glazkova SV, et al. Drug correction of cognitive disorders in cerebral palsy — «Cerebrolysin» in pediatric neurological practice. Detskaya i podrostkovaya reabilitatsiya. 2013;1(20):61-70. (In Russ.).
  85. Tang, et al. A study on the effect treated by Cerebrolysin and home training in the cerebral palsy. Acta Univ Medic Anhui. 1999;34(3):192-193. 
  86. Baozhen X. The efficacy of Cerebrolysin in the rehabilitation of CP in children. Journal of Chinese Practical Medicine. 2002;4(9):83. 
  87. Chutko LS, Yakovenko EA, Surushkina SYu, et al. Clinical and neurophysiological heterogeneity of attention deficit hyperactivity disorder. S.S. Korsakov Journal of Neurology and Psychiatry. 2016;10:117-121. (In Russ.). https://doi.org/10.17116/jnevro2016116101117-121
  88. Zavadenko NN, Guzilova LS, Iznak AF, Iznak EV. Consequences of severe traumatic brain injury in adolescents: features of clinical manifestations and treatment. Voprosy sovremennoj pediatrii. 2010;9(4):2-11. (In Russ.).
  89. Hassanein SM, Deifalla SM, El-Houssinie M, et al. Safety and Efficacy of Cerebrolysin in Infants with Communication Defects due to Severe Perinatal Brain Insult: A Randomized Controlled Clinical Trial. J Clin Neurol. 2016;12(1):79-84.  https://doi.org/10.3988/jcn.2016.12.1.79
  90. Skripchenko NV, Rosin YuA, Ivanova MV, et al. Therapeutic efficacy of cerebrolysin in bacterial purulent meningitis in children. Trudnyj patsient. 2008;6(9):32-38. (In Russ.).
  91. Ogar DV. Improving the adaptive capabilities of disabled children with mental retardation by psychocorrective methods against the background of the use of cerebrolysin. Vestnik vserossijskogo obshchestva spetsialistov po mediko-sotsial’noj ekspertize, reabilitatsii i reabilitatsionnoj industrii. 2006;1-2(8-9):133-135. (In Russ.).
  92. Krasnoperova MG, Bashina VM, Skvortsov IA, Simashkova NV. The effect of cerebrolysin on cognitive functions in childhood autism and Asperger syndrome. S.S. Korsakov Journal of Neurology and Psychiatry. 2002;103(6):15-18. (In Russ.).
  93. Lobova VS. Results of treatment with cerebrolysin of residual neuropsychiatric diseases in childhood. Materialy Vsesoyuznoj i 5-j oblastnoj konferentsii nevropatologov, psikhiatrov, nejrokhirurgov. Sverdlovsk; 1970:222-224. (In Russ.).
  94. Zelenina EN, Kudryakova NP, Klimenko VA, et al. Treatment of cerebral palsy and paresis with cerebrolysin. Tezisy 12-j nauchnoj sessii Leningradskogo nauchno-issledovatel’skogo detskogo ortopedicheskogo instituta. L.; 1970:52-56. (In Russ.).
  95. Shakirova TM, Loskutova VN, Kuzmina YuS, Polumiskova LA. Experience of treatment with cerebrolysin in children with cerebral palsy and combined with mental disability. Zdravookhranenie Kazakhstana. 1970;2:46-48. (In Russ.).
  96. Sharofiddinov IA, Ganieva MT, Isokova MJ, et al. Issues of medical treatment and social rehabilitation of cerebral palsy. Vestnik poslediplomnogo obrazovaniya v sfere zdravookhraneniya. 2020;4:60-64. (In Russ.).
  97. Gainetdinova DD, Semenov VV, Ismagilov MF, Kharitonov VS. Clastogenic, aneugenic, prooxidant and antioxidant properties of some neurotropic drugs. Eksperimental’naya i klinicheskaya farmakologiya. 2006;69(3):58-62. (In Russ.).
  98. Semenova KA, Gromova OA, Kulagina YuM, et al. Dynamics of activity of antioxidant enzymes in erythrocytes in children with cerebral palsy under the influence of cerebrolysin. Mikroelementy v pediatrii. 2001;2(4):40-43. (In Russ.).
  99. Nemkova SA, Maslova OI. The effectiveness of the method of dynamic proprioceptive correction in patients with infantile cerebral palsy with cognitive impairment. S.S. Korsakov Journal of Neurology and Psychiatry. 2013;113(8):26-32. (In Russ.).
  100. YildirimY, Budak M, Tarakci D, et al. The Effect of Video-Based Games on Hand Functions and Cognitive Functions in Cerebral Palsy, Games for Health Journal. 2021;10(3):180-189.  https://doi.org/10.1089/g4h.2020.0182
  101. Di Lieto MC, Pecini C, Brovedani P, et al. Adaptive Working Memory Training Can Improve Executive Functioning and Visuo-Spatial Skills in Children With Pre-term Spastic Diplegia. Front Neurol. 2021;11:601148. https://doi.org/10.3389/fneur.2020.601148

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