The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Login
EN
+7 (495) 482-4118
+7 (495) 482-0604
+8 800 250-18-12
  • (toll-free number for subscriptions)
    Mon-Fri from 10 a.m. to 6 p.m.

  • © 1998-2025
+7 (495) 482-43-29
EN
All journals
Journal
Year
Year
Search result: 0

Pomytkin A.N.

Mental Health Research Center

Lebedeva I.S.

Mental Health Research Center

Tikhonov D.V.

Mental Health Research Center

Kaleda V.G.

Mental Health Research Centre

Rhythmic transcranial magnetic stimulation in the treatment of resistant depression in schizophrenia

Authors:

Pomytkin A.N., Lebedeva I.S., Tikhonov D.V., Kaleda V.G.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2021;121(5‑2): 99‑105

DOI: 10.17116/jnevro202112105299

Read: 2983 times

Download PDF (RU)
Contact the author
Table of contents

RHYTHMIC TRANSCRANIAL MAGNETIC STIMULATION IN THE TREATMENT OF RESISTANT DEPRESSION IN SCHIZOPHRENIA
RHYTHMIC TRANSCRANIAL MAGNETIC STIMULATION IN THE TREATMENT OF RESISTANT DEPRESSION IN SCHIZOPHRENIA

To cite this article:

Pomytkin AN, Lebedeva IS, Tikhonov DV, Kaleda VG. Rhythmic transcranial magnetic stimulation in the treatment of resistant depression in schizophrenia. S.S. Korsakov Journal of Neurology and Psychiatry. 2021;121(5‑2):99‑105. (In Russ.)
https://doi.org/10.17116/jnevro202112105299

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова. Спецвыпуски (S.S. Korsakov Journal of Neurology and Psychiatry (special issues))
 
МСФ на ЯМ
Использование инфографики авторами научных работ
Close metadata
Recommended articles:
Psychopathological diso­rders at the onset of juve­nile parkinsonism in childhood. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(11-2):96-102
Impact of various reha­bilitation programs on anxiety and depression after surgery of early-stage cervical cancer. Problems of Balneology, Physiotherapy and Exercise Therapy. 2024;(5):40-44
Transcranial magnetic stimulation (rTMS) in the treatment of depressive diso­rders. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(10):55-59
The rela­tionship between inflammatory markers, fati­gue, and effort-based deci­sion-making in patients at clinical high risk for psychosis. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(10):85-91
Predictors of atrial fibrillation recu­rrence after biatrial cryo-maze procedure: a systematic review. Piro­gov Russian Journal of Surgery. 2024;(11):100-104
Predictors of aortic valve dysfunction after the Ozaki procedure. Russian Journal of Cardiology and Cardiovascular Surgery. 2024;(6):624-628
The gut microbiota in bipo­lar diso­rder. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(11):28-33
The role of immuno-inflammatory factors in the deve­lopment of nega­tive symptoms in schi­zophrenia. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(11):42-48
A role of transcription factors in pathogenic processes asso­ciated with schi­zophrenia. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(11):49-54
Como­rbidity of depression and deme­ntia: epidemiological, biological and therapeutic aspe­cts. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(11):113-121
Abstract:

Rhythmic transcranial magnetic stimulation (rTMS) has long been actively used in the treatment of depressive disorders in various mental illnesses. At the same time, the question of the predictability of the results of this method for an individual patient remains open. Based on the existing ideas about the relationship of rTMS mechanisms with changes in the state of neural networks, one of the most perspective line is the search for prognostically significant neurophysiological markers. The study analyzed a wide range of EEG characteristics and evoked potentials recorded before treatment in the groups of responders and nonresponders in patients with depressive symptoms in schizophrenia, who have completed a course of rhythmic transcranial magnetic stimulation. The study revealed associations between an unfavorable treatment outcome and greater coherence in the alpha range (mainly in the caudal regions bilaterally) and less coherence in the beta1 range (involving temporal leads and left-hemisphere asymmetry). At the same time, such indicators as the amplitude of the N100 wave and the negativity of the mismatch were uninformative in terms of predicting the effectiveness of therapy.

Keywords:

TMS
depression
adolescence
schizophrenia
EEG
EP
predictors

Authors:

Pomytkin A.N.

Mental Health Research Center

Lebedeva I.S.

Mental Health Research Center

Tikhonov D.V.

Mental Health Research Center

Kaleda V.G.

Mental Health Research Centre

Received:

03.03.2021

Accepted:

22.03.2021

Close metadata

References:

  1. Mazo GE, Kazantseva KV. Optimizatsiya podkhodov k diagnostike i terapii depressii pri shizofrenii. Metodicheskie rekomendatsii SPb: Sankt-Peterburgskii Psikhonevrologicheskii Institut im. V.M. Bekhtereva. 2012;17. Accessed 24.02.21. (In Russ.). https://www.elibrary.ru/item.asp?id=29151429
  2. Krynicki CR, Upthegrove R, Deakin JF, Barnes TR. The relationship between negative symptoms and depression in schizophrenia: a systematic review. Acta Psychiatrica Scandinavica. 2018;137(5):380-390.  https://doi.org/10.1111/acps.12873
  3. Upthegrove R, Marwaha S, Birchwood M. Depression and Schizophrenia: Cause, Consequence, or Trans-diagnostic Issue? Schizophrenia Bulletin. 2017;43(2):240-244.  https://doi.org/10.1093/schbul/sbw097
  4. van Rooijen G, van Rooijen M, Maat A. Longitudinal evidence for a relation between depressive symptoms and quality of life in schizophrenia using structural equation modeling. Schizophrenia Research journal. 2019;208:82-89.  https://doi.org/10.1016/j.schres.2019.04.011
  5. Li W, Yang Y, Feng-Rong An, Zhang L, Ungvari GS, Jackson T, Yuan Z, Xiang Y. Prevalence of comorbid depression in schizophrenia: A meta-analysis of observational studies. Journal of Affective Disorders. 2020;273:524-531.  https://doi.org/10.1016/j.jad.2020.04.056
  6. Melkerson MN. Special Premarket 510(k) Notification for NeuroStar TMS Therapy System for Major Depressive Disorder (pdf). FDA (2008-12-16). The link is active at 24.02.21.  https://www.accessdata.fda.gov/cdrh_docs/pdf8/K083538.pdf
  7. Perera T, George MS., Grammer G, Janicak PG, Pascual-Leone A, Wiercki TS. The Clinical TMS Society Consensus Review and Treatment Recommendations for TMS Therapy for Major Depressive Disorder. Brain Stimulation. 2016;9(3):336-346.  https://doi.org/10.1016/j.brs.2016.03.010
  8. McClintock SM, Irving MR, Carpenter LL, McDonald WM, Dubin M., Taylor SF, Cook IA, O’Reardon J, Husain MM, Wall C, Krystal AD, Sampson SM, Morales O, Nelson BG, Latoussakis V, George MS, Lisanby SH. Consensus Recommendations for the Clinical Application of Repetitive Transcranial Magnetic Stimulation (rTMS) in the Treatment of Depression. The Journal of Clinical Psychiatry. 2018;79(1):16cs10905. https://doi.org/10.4088/JCP.16cs10905
  9. Maslennikov NV, Tsukarzi EE, Mosolov SN. Effektivnost’ transkranial’noi magnitnoi stimulyatsii (TMS) pri depressiyakh u bol’nykh shizofreniei. Obozrenie Psikhiatrii i Meditsinskoi Psikhologii im. V.M. Bekhtereva. 2009;4. Accessed 24.02.21. (In Russ.). https://www.elibrary.ru/item.asp?id=24250368
  10. Maslenikov NV, Tsukarzi EE, Mosolov SN. Depression in schizophrenia: Eevalution of cognitive functioning changes in patients treated with transcranial magnetic stimulation (TMS). Sotsial’naya i Klinicheskaya Psikhiatriya. 2013;23(1):5-11. Accessed 24.02.21. (In Russ.). https://www.elibrary.ru/item.asp?id=19015904
  11. Hui J, Tremblay S, Daskalakis ZJ. The Current and Future Potential of Transcranial Magnetic Stimulation With Electroencephalography in Psychiatry. Clinical Pharmacology & Therapeutics. 2019;106(4):734-746. Epub 2019 Aug 30.  https://doi.org/10.1002/cpt.1541
  12. Pomytkin A.N., Kaleda V.G., Klochkova I.V., Lebedeva I.S. The effectiveness of high-frequency rhythmic transcranial magnetic stimulation in endogenous depressive disorders in youth. Zhurnal Nevrologii i Psikhiatrii im. S.S. Korsakova. 2019;119(12):38-45. Accessed 24.02.21. (In Russ.). https://www.mediasphera.ru/issues/zhurnal-nevrologii-i-psikhiatrii-im-s-s-korsakova/2019/12/1199772982019121038
  13. Naatanen R, Picton T. The N1 wave of the human electric and magnetic response to sound: a review and an analysis of the component structure. Psychophysiology. 1987;24(4):375-425.  https://doi.org/10.1111/j.1469-8986.1987.tb00311.x
  14. Bissonnette JN, Ashley MF, Krista MH, Leckey J, Pimer L, Berrigan LI, Fisher DJ. MMN-Indexed Auditory Change Detection in Major Depressive Disorder. Clinical EEG and Neuroscience. 2020;51(6):365-372.  https://doi.org/10.1177/1550059420914200
  15. Lebedeva IS, Kaleda VG, Abramova LI, Barkhatova AN, Omel’chenko MA. Neurophysiological abnormalities in the p300 paradigm as endophenotypes of schizophrenia. Zhurnal Nevrologii i Psikhiatrii im. C.C. Korsakova. 2008;108:1:61-70. Accessed 24.02.21. (In Russ.). https://www.elibrary.ru/item.asp?id=9947648
  16. Jiang M, Su Y, Liu G, Chen W, Gao D. Predicting the non-survival outcome of large hemispheric infarction patients via quantitative electroencephalography: Superiority to visual electroencephalography and the Glasgow Coma Scale. Neuroscience Letters. 2019;706:88-92.  https://doi.org/10.1016/j.neulet.2019.05.007
  17. Zandvakili A, Philip NS, Jones SR, Tyrka AR, Greenberg BD, Carpenter LL. Use of machine learning in predicting clinical response to transcranial magnetic stimulation in comorbid posttraumatic stress disorder and major depression: A resting state electroencephalography study. Journal of Affective Disorders. 2019;252:47-54.  https://doi.org/10.1016/j.jad.2019.03.077
  18. Moslov SN, Tsukarzi EE, Alfimov PV. Algoritmy biologicheskoi terapii shizofrenii. Sovremennaya Terapiya Psikhicheskikh Rasstroistv. 1 2014;1:27-36. Accessed 24.02.21. (In Russ.). https://www.elibrary.ru/item.asp?id=21368617
  19. Spitzer B, Haegens S. Beyond the Status Quo: A Role for Beta Oscillations in Endogenous Content (Re)Activation. eNeuro. 2017;4(4):Eneuro.0170-17.2017. https://doi.org/10.1523/ENEURO.0170-17.2017
  20. Kam JWY, Bolbecker AR, O’Donnell BF, Hetrick WP, Brenner CA. Resting state EEG power and coherence abnormalities in bipolar disorder and schizophrenia. Journal of Psychiatric Research. 2013;47(12):1893-1901. https://doi.org/10.1016/j.jpsychires.2013.09.009
  21. Higashima M, Takeda T, Kikuchi M, Nagasawa T, Hirao N, Oka T, Nakamura M, Koshino Y. State-dependent changes in intrahemispheric EEG coherence for patients with acute exacerbation of schizophrenia. Journal of Psychiatric Research. 2007;149(1-3):41-47.  https://doi.org/10.1016/j.psychres.2005.05.020
  22. Zandvakili A, Philip NS, Jones SR, Tyrka AR, Greenberg BD, Carpenter LL. Use of machine learning in predicting clinical response to transcranial magnetic stimulation in comorbid posttraumatic stress disorder and major depression: A resting state electroencephalography study. Journal of Affective Disorders. 2019;252:47-54.  https://doi.org/10.1016/j.jad.2019.03.077
  23. Varlamov AA, Strelets VB. EEG Coherence Analysis in Depressive Disorders and Its Possible Use in Clinical Practice: A Literature Review. Zhurnal Vysshei Nervnoi Deyatel’nosti. 2013;63:6:1-12. (In Russ.). https://doi.org/10.7868/S004446771306018X
  24. Lapin IA, Alfimova MV. EEG-markers for depressive conditions. Sotsial’naya i Klinicheskaya Psikhiatriya. 2014;24:4. Accessed 24.02.21. (In Russ.). https://www.elibrary.ru/item.asp?id=24154766
  25. Mel’nikova TS, Lapin IA, Sarkisyan VV. Use of coherent EEG analysis in psychiatry. Sotsial’naya i Klinicheskaya Psikhiatriya. 2009;19:1:90-94. Accessed 24.02.21. (In Russ.). https://www.elibrary.ru/item.asp?id=12060984
  26. Drysdale AT, Grosenick L, Downar J, Dunlop K, Mansouri F, Meng Y, Fetcho RN, Zebley B, Oathes DJ, Etkin A, Schatzberg AF, Sudheimer K, Keller J, Mayberg HS, Gunning FM, Alexopoulos GS, Fox MD, Pascual-Leone A, Voss HU, Casey BJ, Dubin MJ, Liston C. Resting-state connectivity biomarkers define neurophysiological subtypes of depression. Nature Medicine. 2017;23(1):28-38.  https://doi.org/10.1038/nm.4246
  27. Fox MD, Buckner RL, White MP, Greicius MD, Pascual-Leone A. Efficacy of transcranial magnetic stimulation targets for depression is related to intrinsic functional connectivity with the subgenual cingulate. Biological Psychiatry. 2012;72:595603. https://doi.org/10.1016/j.biopsych.2012.04.028
  28. Weigand A, Horn A, Ruth C, Cooke D, Stern A, Taylor S, Press D, Pascual-Leone A, Fox MD. Prospective Validation That Subgenual Connectivity Predicts Antidepressant Efficacy of Transcranial Magnetic Stimulation Sites. Biological Psychiatry. 2018;84(1):28-37.  https://doi.org/10.1016/j.biopsych.2017.10.028
  29. Hadas I, Sun Y, Lioumis P, Zomorrodi R, Jones B, Voineskos D, Downar J, Fitzgerald PB, Blumberger DM, Daskalakis ZJ. Association of Repetitive Transcranial Magnetic Stimulation Treatment With Subgenual Cingulate Hyperactivity in Patients With Major Depressive Disorder: A Secondary Analysis of a Randomized Clinical Trial. JAMA Network Open. 2019;2(6):e195578. https://doi.org/10.1001/jamanetworkopen.2019.5578
  30. Hasan A, Guse B, Cordes J, Wolwer W, Winterer G, Gaebel W, Langguth B, Landgrebe M, Eichhammer P, Frank E, Hajak G, Ohmann C, Verde PE, Rietschel M, Ahmed R, Honer WG, Malchow B, Karch S, Schneider-Axmann T, Falkai P, Wobrock T. Cognitive Effects of High-Frequency rTMS in Schizophrenia Patients With Predominant Negative Symptoms: Results From a Multicenter Randomized Sham-Controlled Trial. Schizophrenia Bulletin. 2016;42(3):608-618.  https://doi.org/10.1093/schbul/sbv142
Contact the author
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.

Email Confirmation

An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

Email Confirmation

Contact us
If you have any questions, complaints or suggestions, please use this feedback form.
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.
Submit Application

You can become an author of one of our magazines, send a request and we will consider it in during the day.

Name
Phone
E-mail
Message
Login
Registration
E-mail
Password
Forgot Password?

Log in to the site using your account in one of the services

Password recovery
E-mail
Login
Register

We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.