Modern approaches to the genetics of depression: scopes and limitations

Kasyanov ED, Rukavishnikov GV, Kibitov AA, Malyshko LV, Neznanov NG, Kibitov AO, Mazo GE. Modern approaches to the genetics of depression: scopes and limitations. S.S. Korsakov Journal of Neurology and Psychiatry. 2021;121(5‑2):61‑66. (In Russ.)
https://doi.org/10.17116/jnevro202112105261

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова. Спецвыпуски (S.S. Korsakov Journal of Neurology and Psychiatry (special issues))

Использование инфографики авторами научных работ

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SUMMARY

Recent findings in candidate genes for depression showed significant replication failures and thus appeared irrelevant. Much of the earlier studies’ limitations can be overcome by the strategy of genome-wide association studies (GWAS), which aims to identify associations between different genomic variants and phenotypic traits without pathophysiological hypotheses application. With the use of such studies, it seems possible to calculate polygenic risk scores (PRS) as a promising approach for predicting depression risk. The aim of this review is to analyze modern approaches of genetic research used to assess the risk of depression in a population.

Keywords:

depression

psychiatric genetics

GWAS

PRS

Authors:

Kasyanov E.D.

Bekhterev National Medical Research Center for Psychiatry and Neurology

ORCID: 0000-0002-4658-2195

Rukavishnikov G.V.

Bekhterev National Medical Research Center for Psychiatry and Neurology

ORCID: 0000-0002-5282-2036

Kibitov A.A.

Centre for Mental Health Research

ORCID: 0000-0001-7766-9675

Malyshko L.V.

Bekhterev National Medical Research Center for Psychiatry and Neurology

ORCID: 0000-0002-5470-4359

Neznanov N.G.

Bekhterev National Medical Research Center for Psychiatry and Neurology;
Pavlov First Saint-Petersburg State Medical University

ORCID: 0000-0001-5618-4206

Kibitov A.O.

Serbsky National Medical Research Center for Psychiatry and Narcology

ORCID: 0000-0002-8771-625X

Mazo G.E.

Bekhterev National Medical Research Center for Psychiatry and Neurology

ORCID: 0000-0001-7910-9129

Received:

30.03.2021

Accepted:

05.04.2021

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References:

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