Disorders of social cognitive functions in patients after stroke

Kutlubaev M.A.; Ozerova A.I.; Mendelevich V.D.

doi:https://doi.org/10.17116/jnevro20211211229

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Abstract:

Social cognitive functions used to encode and decode social information, and are critical for people to understand themselves and others, as well as the norms and procedures of the social world. They could be subdivided into theory of mind, social perception, affective empathy and social behavior. From neuroanatomical viewpoint disorders of social cognitive functions are related to the dysfunction of the certain areas of frontal and temporal lobes of the brain and their connections. In contrast to psychiatric disorders social cognitive deficit is heterogeneous in its nature and depends on the lesion location. Disorders of theory of mind, social perception and social behavior significantly more often are seen in patients after stroke than in healthy people. Social cognitive deficit has a negative effect on the outcome of stroke. More research is needed in this area.

Keywords:

social cognitive functions

theory of mind

behavior

stroke

Authors:

Kutlubaev M.A.

Bashkir State Medical University

SPIN RSCI: 4713-0312
Scopus AuthorID: 9241930700
ORCID: 0000-0003-1001-2024

Ozerova A.I.

Bashkir State Medical University

SPIN RSCI: 6827-5675
Scopus AuthorID: 57430382500
ORCID: 0000-0003-0131-1524

Mendelevich V.D.

Kazan State Medical University

ORCID: 0000-0002-8476-6083

Received:

11.03.2021

Accepted:

29.03.2021

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References:

Henry JD, von Hippel W, Molenberghs P, Lee T, Sachdev PS. Clinical assessment of social cognitive function in neurological disorders. Nat Rev Neurol. 2016;12(1):28-39. https://doi.org/10.1038/nrneurol.2015.22
Chimagomedova ASh, Lyashenko EA, Babkina OV, Yakovleva OV, Vasenina EE, Levin OS. Social cognitive function in neurodegenerative diseases. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova. 2017;117(11):168-173. (In Russ.). https://doi.org/10.17116/jnevro2017117111168-173.
Frith C, Frith U. Theory of mind. Curr Biol. 2005;15(17):644-646. https://doi.org/10.1016/j.cub.2005.08.041
Mitchell RLC, Phillips LH. The overlapping relationship between emotion perception and theory of mind. Neuropsychologia. 2015;70:1-10. https://doi.org/10.1016/j.neuropsychologia.2015.02.018
Shamay-Tsoory SG, Tomer R, Goldsher D, Berger BD, Aharon-Peretz J. Impairment in cognitive and affective empathy in patients with brain lesions: anatomical and cognitive correlates. J Clin Exp Neuropsychol. 2004;26(8):1113-1127. https://doi.org/10.1080/13803390490515531
Grace J, Stout JC, Malloy PF. Assessing frontal lobe behavioral syndromes with the frontal lobe personality scale. Assessment. 1999;6(3):269-284. https://doi.org/10.1177/107319119900600307
Carter RM, Huettel SA. A nexus model of the temporal-parietal junction. Trends Cogn Sci. 2013;17(7):328-336. https://doi.org/10.1016/j.tics.2013.05.007
Szczepanski SM, Knight RT. Insights into human behavior from lesions to the prefrontal cortex. Neuron. 2014;83(5):1002-1018. https://doi.org/10.1016/j.neuron.2014.08.011
Beer JS, John OP, Scabini D, Knight RT. Orbitofrontal cortex and social behavior: integrating self-monitoring and emotion-cognition interactions. J Cogn Neurosci. 2006;18(6):871-879. https://doi.org/10.1162/jocn.2006.18.6.871
Blair RJ, Curran HV. Selective impairment in the recognition of anger induced by diazepam. Psychopharmacology (Berl). 1999;147(3):335-338. https://doi.org/10.1007/s002130051177
Beacher FD, Gray MA, Minati L, Whale R, Harrison NA, Critchley HD. Acute tryptophan depletion attenuates conscious appraisal of social emotional signals in healthy female volunteers. Psychopharmacology (Berl). 2011;213(2-3):603-613. https://doi.org/10.1007/s00213-010-1897-5
Rodrigues SM, Saslow LR, Garcia N, John OP, Keltner D. Oxytocin receptor genetic variation relates to empathy and stress reactivity in humans. Proc Natl Acad Sci USA. 2009;106(50):21437-21441. https://doi.org/10.1073/pnas.0909579106
Meyer-Lindenberg A, Domes G, Kirsch P, Heinrichs M. Oxytocin and vasopressin in the human brain: social neuropeptides for translational medicine. Nat Rev Neurosci. 2011;12(9):524-538. https://doi.org/10.1038/nrn3044
Adams AG, Schweitzer D, Molenberghs P, Henry JD. A meta-analytic review of social cognitive function following stroke. Neurosci Biobehav Rev. 2019;102:400-416. https://doi.org/10.1016/j.neubiorev.2019.03.011
Nijsse B, Spikman JM, Visser-Meily JMA, de Kort PLM, van Heugten CM. Social cognition impairments are associated with behavioural changes in the long term after stroke. PLoS One. 2019;14(3):e0213725. https://doi.org/10.1371/journal.pone.0213725
Milders M, Fuchs S, Crawford JR. Neuropsychological impairments and changes in emotional and social behaviour following severe traumatic brain injury. J Clin Exp Neuropsychol. 2003;25(2):157-172. https://doi.org/10.1076/jcen.25.2.157.13642
Baron-Cohen S, Wheelwright S. The empathy quotient: an investigation of adults with Asperger syndrome or high functioning autism, and normal sex differences. J Autism Dev Disord. 2004;34:163-175.
Bohl V, van den Bos W. Toward an integrative account of social cognition: marrying theory of mind and interactionism to study the interplay of Type 1 and Type 2 processes. Front Hum Neurosci. 2012;6:274. https://doi.org/10.3389/fnhum.2012.00274
Van Overwalle, F. Social cognition and the brain: a meta-analysis. Human Brain Mapping. 2009;30:829-858. https://doi.org/10.1002/hbm.20547
Molenberghs P, Johnson H, Henry JD, Mattingley JB. Understanding the minds of others: A neuroimaging meta-analysis. Neurosci Biobehav Rev. 2016;65:276-291. https://doi.org/10.1016/j.neubiorev.2016.03.020
Schurz M, Radua J, Aichhorn M, Richlan F, Perner J. Fractionating theory of mind: a meta-analysis of functional brain imaging studies. Neurosci Biobehav Rev. 2014;42:9-34. https://doi.org/10.1016/j.neubiorev.2014.01.009
Coricelli G. Two-levels of mental states attribution: from automaticity to voluntariness. Neuropsychologia. 2005;43(2):294-300. https://doi.org/10.1016/j.neuropsychologia.2004.11.015
Keysers C, Gazzola V. Integrating simulation and theory of mind: from self to social cognition. Trends Cogn Sci. 2007;11(5):194-196. https://doi.org/10.1016/j.tics.2007.02.002
Völlm BA, Taylor AN, Richardson P, Corcoran R, Stirling J, McKie S, Deakin JF, Elliott R. Neuronal correlates of theory of mind and empathy: A functional magnetic resonance imaging study in a nonverbal task. Neuroimage. 2006;29(1):90-98. https://doi.org/10.1016/j.neuroimage.2005.07.022
Keysers C, Gazzola V. Expanding the mirror: vicarious activity for actions, emotions, and sensations. Curr Opin Neurobiol. 2009;19(6):666-671. https://doi.org/10.1016/j.conb.2009.10.006
Rizzolatti G, Fabbri-Destro M. The mirror system and its role in social cognition. Curr Opin Neurobiol. 2008;18(2):179-184. https://doi.org/10.1016/j.conb.2008.08.001
Saxe R. Against simulation: the argument from error. Trends Cogn Sci. 2005;9(4):174-179. https://doi.org/10.1016/j.tics.2005.01.012
Saxe R. Uniquely human social cognition. Curr Opin Neurobiol. 2006;16(2): 235-239. https://doi.org/10.1016/j.conb.2006.03.001
Amodio DM, Frith CD. Meeting of minds: the medial frontal cortex and social cognition. Nat Rev Neurosci. 2006;7(4):268-277. https://doi.org/10.1038/nrn1884
Gallagher HL, Frith CD. Functional imaging of ‘theory of mind’. Trends Cogn Sci. 2003;7(2):77-83. https://doi.org/10.1016/s1364-6613(02)00025-6
Phillips ML, Drevets WC, Rauch SL, Lane R. Neurobiology of emotion perception I: The neural basis of normal emotion perception. Biol Psychiatry. 2003;54(5):504-514. https://doi.org/10.1016/s0006-3223(03)00168-9
Mitchell RL, Phillips LH. The overlapping relationship between emotion perception and theory of mind. Neuropsychologia. 2015;70:1-10. https://doi.org/10.1016/j.neuropsychologia.2015.02.018
Fiske ST, Taylor SE. Social cognition (2nd edn). New York: McGraw-Hill; 1991.
Blonder LX, Bowers D, Heilman KM. The role of the right hemisphere in emotional communication. Brain. 1991;114(Pt 3):1115-1127. Erratum in: Brain. 1992 Apr;115(Pt 2):645. https://doi.org/10.1093/brain/114.3.1115
Braun M, Traue HC, Frisch S, Deighton RM, Kessler H. Emotion recognition in stroke patients with left and right hemispheric lesion: results with a new instrument-the FEEL Test. Brain Cogn. 2005;58(2):193-201. https://doi.org/10.1016/j.bandc.2004.11.003
Kucharska-Pietura K, Phillips ML, Gernand W, David AS. Perception of emotions from faces and voices following unilateral brain damage. Neuropsychologia. 2003;41(8):1082-1090. https://doi.org/10.1016/S0028-3932(02)00294-4
Van Overwalle F, Manto M, Cattaneo Z, Clausi S, Ferrari C, Gabrieli JDE, Guell X, Heleven E, Lupo M, Ma Q, Michelutti M, Olivito G, Pu M, Rice LC, Schmahmann JD, Siciliano L, Sokolov AA, Stoodley CJ, van Dun K, Vandervert L, Leggio M. Consensus Paper: Cerebellum and Social Cognition. Cerebellum. 2020;19(6):833-868. https://doi.org/10.1007/s12311-020-01155-1
Cooper CL, Phillips LH, Johnston M, Radlak B, Hamilton S, McLeod MJ. Links between emotion perception and social participation restriction following stroke. Brain Inj. 2014;28(1):122-126. https://doi.org/10.3109/02699052.2013.848379
Honan CA, McDonald S, Sufani C, Hine DW, Kumfor F. The awareness of social inference test: development of a shortened version for use in adults with acquired brain injury. Clin Neuropsychol. 2016;30(2):243-264. https://doi.org/10.1080/13854046.2015.1136691
Grattan LM, Bloomer RH, Archambault FX, Eslinger PJ. Cognitive flexibility and empathy after frontal lobe lesion. Neuropsychiatr Neuropsychol Behav Neurol. 1994;7(4):251-259.
Yeh ZT, Tsai CF. Impairment on theory of mind and empathy in patients with stroke. Psychiatry Clin Neurosci. 2014;68(8):612-620. https://doi.org/10.1111/pcn.12173
Grace J, Stout JC, Malloy PF. Assessing frontal lobe behavioral syndromes with the frontal lobe personality scale. Assessment. 1999;6(3):269-284. https://doi.org/10.1177/107319119900600307
Adolfi F, Couto B, Richter F, Decety J, Lopez J, Sigman M, Manes F, Ibáñez A. Convergence of interoception, emotion, and social cognition: A two fold fMRI meta-analysis and lesion approach. Cortex. 2017;88:124-142. https://doi.org/10.1016/j.cortex.2016.12.019
Friedler B, Crapser J, McCullough L. One is the deadliest number: The detrimental effects of social isolation on cerebrovascular diseases and cognition. Acta Neuropathol. 2015;129(4):493-509. https://doi.org/10.1007/s00401-014-1377-9
Corgnet B, Espín AM, Hernán-González R. The cognitive basis of social behavior: cognitive reflection overrides antisocial but not always prosocial motives. Front Behav Neurosci. 2015;9:287. https://doi.org/10.3389/fnbeh.2015.00287
Adams AG, Henry JD, Molenberghs P, Robinson GA, Nott Z, von Hippel W. The relationship between social cognitive difficulties in the acute stages of stroke and later functional outcomes. Soc Neurosci. 2020;15(2):158-169. https://doi.org/10.1080/17470919.2019.1668845