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Koroleva E.S.

Siberian State Medical University

Brazovskaya N.G.

Siberian State Medical University

Levchuk L.A.

Tomsk National Research Medical Center of the Russian Academy of Sciences

Kazakov S.D.

Siberian State Medical University

Romadina N.Y.

Tomsk Regional Clinical Hospital

Alifirova V.M.

Siberian State Medical University

Assessment of the levels of neuron-specific enolase and BDNF at the stages of rehabilitation in the acute and early recovery periods of ischemic stroke

Authors:

Koroleva E.S., Brazovskaya N.G., Levchuk L.A., Kazakov S.D., Romadina N.Y., Alifirova V.M.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2020;120(8‑2): 30‑36

DOI: 10.17116/jnevro202012008230

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ASSESSMENT OF THE LEVELS OF NEURON-SPECIFIC ENOLASE AND BDNF AT THE STAGES OF REHABILITATION IN THE ACUTE AND EARLY RECOVERY PERIODS OF ISCHEMIC STROKE
ASSESSMENT OF THE LEVELS OF NEURON-SPECIFIC ENOLASE AND BDNF AT THE STAGES OF REHABILITATION IN THE ACUTE AND EARLY RECOVERY PERIODS OF ISCHEMIC STROKE

To cite this article:

Koroleva ES, Brazovskaya NG, Levchuk LA, Kazakov SD, Romadina NY, Alifirova VM. Assessment of the levels of neuron-specific enolase and BDNF at the stages of rehabilitation in the acute and early recovery periods of ischemic stroke. S.S. Korsakov Journal of Neurology and Psychiatry. 2020;120(8‑2):30‑36. (In Russ.)
https://doi.org/10.17116/jnevro202012008230

Подписка 2025-2 (S.S. Korsakov Journal of Neurology and Psychiatry (special issues))
 
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BACKGROUND

The issue of the diagnostic significance and clinical value of neuron-specific enolase (NSE) and brain-derived neurotropic factor (BDNF) in the acute period of stroke remains controversial. Therefore, it is advisable to study the correlation of biomarkers with the clinical characteristics of stroke in the time period of early recovery.

OBJECTIVE

To monitor NSE and BDNF levels in peripheral blood, to analyze the clinical and laboratory correlations in patients with ischemic stroke at the stages of medical rehabilitation in the early recovery period.

MATERIAL AND METHODS

Forty-nine patients with ischemic stroke in the middle cerebral artery were examined. The observation period is 90 days. Observation Points are Day 1; Day 14; Day 45; Day 90. The National Institute of Health Stroke Scale (NIHSS), the Fugle-Meyer Scale (FMA), the Modified Rankin Scale (mRS) were administered. NSE was determined in blood serum by enzyme-linked immunosorbent assay, BDNF was analyzed on a multiplex analyzer.

RESULTS AND CONCLUSION

NSEDay1 in patients was significantly higher than in the comparison group (pDay1—comparison group<0.001) with a trend to a maximum decrease on the 90th day of stroke (pDay1—90<0.001). BDNFDay1 turned out to be lower than in the comparison group (pDay1—comparison group=0.006) and significantly increased by the 14th day of the stroke (pDay1—14<0.001; pDay14—comparison group=0.637). A negative correlation was found between a decrease in NSEDay14 and an increase in BDNFDay14 (r= –0.349; p=0.05). A positive correlation was found between an increase in BDNFDay14 and a decrease in mRS scores Day90 (r=0.499, p=0.035). Outcomes in patients in group 1 (after stages I and II of rehabilitation) on the assessment scales were significantly better than in patients discharged after stage I for outpatient monitoring — group 2 (p<0.05). In group 1, BDNFDay90 did not differ from BDNFDay14 (pDay14—90—Group1=0.17), and in group 2 it was significantly lower by the end of the early recovery period (pDay14—90—Group2=0.002).

Keywords:

ischemic stroke
neuron-specific enolase
brain-derived neurotropic factor
rehabilitation
early recovery period

Authors:

Koroleva E.S.

Siberian State Medical University

Brazovskaya N.G.

Siberian State Medical University

Levchuk L.A.

Tomsk National Research Medical Center of the Russian Academy of Sciences

Kazakov S.D.

Siberian State Medical University

Romadina N.Y.

Tomsk Regional Clinical Hospital

Alifirova V.M.

Siberian State Medical University

Received:

14.03.2020

Accepted:

15.03.2020

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