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Kabaeva A.R.
Pirogov Russian National Research Medical University
Boyko A.N.
Pirogov Russian National Research Medical University;
Federal Center of Brain and Neurotechnologies
Radiologically isolated syndrome: prognosis and predictors of conversion to multiple sclerosis
Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2020;120(7‑2): 7‑12
Read: 1997 times
To cite this article:
Kabaeva AR, Boyko AN, Kulakova OG, Favorova OO. Radiologically isolated syndrome: prognosis and predictors of conversion to multiple sclerosis. S.S. Korsakov Journal of Neurology and Psychiatry.
2020;120(7‑2):7‑12. (In Russ.)
https://doi.org/10.17116/jnevro20201200727
Increased sensitivity and availability of magnetic resonance imaging (MRI) in neurological routine practice led to the fact that more and more experts began to encounter changes typical for multiple sclerosis (MS) according to MRI in the absence of anamnestic and clinical indications of damage to the central nervous system (CNS). This nosological form has been defined as a radiologically isolated syndrome (RIS). More and more RIS cases convert to MS (up to 30% in the first 5 years after RIS diagnosis). At the moment, there are no biological markers that allow combining RIS and MS into one pathological process and early treatment with disease-modifying drugs (DMT). Prospective studies are actively being conducted to identify demographic, clinical, neuroimaging and biochemical conversion predictors. The identification of the molecular biological RIS features, combining these changes with MS, is an urgent scientific task and will allow timely initiation of therapy of the pathological process already at the subclinical stage.
Authors:
Kabaeva A.R.
Pirogov Russian National Research Medical University
Boyko A.N.
Pirogov Russian National Research Medical University;
Federal Center of Brain and Neurotechnologies
Received:
14.05.2020
Accepted:
18.05.2020
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