Radiologically isolated syndrome: prognosis and predictors of conversion to multiple sclerosis

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Increased sensitivity and availability of magnetic resonance imaging (MRI) in neurological routine practice led to the fact that more and more experts began to encounter changes typical for multiple sclerosis (MS) according to MRI in the absence of anamnestic and clinical indications of damage to the central nervous system (CNS). This nosological form has been defined as a radiologically isolated syndrome (RIS). More and more RIS cases convert to MS (up to 30% in the first 5 years after RIS diagnosis). At the moment, there are no biological markers that allow combining RIS and MS into one pathological process and early treatment with disease-modifying drugs (DMT). Prospective studies are actively being conducted to identify demographic, clinical, neuroimaging and biochemical conversion predictors. The identification of the molecular biological RIS features, combining these changes with MS, is an urgent scientific task and will allow timely initiation of therapy of the pathological process already at the subclinical stage.

Keywords:

radiologically isolated syndrome

early multiple sclerosis

MRI

oligoclonal bands

Authors:

Kabaeva A.R.

Pirogov Russian National Research Medical University

SPIN RSCI: 3952-3519
Scopus AuthorID: 57195808362
ORCID: 0000-0002-0982-8520

Boyko A.N.

Pirogov Russian National Research Medical University;
Federal Center of Brain and Neurotechnologies

SPIN RSCI: 9921-9109
Scopus AuthorID: 7102247663
ORCID: 0000-0002-2975-4151

Kulakova O.G.

Pirogov Russian National Research Medical University

ORCID: 0000-0002-5321-3101

Favorova O.O.

Pirogov Russian National Research Medical University

ORCID: 0000-0002-5271-6698

Received:

14.05.2020

Accepted:

18.05.2020

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