The pharmacoeconomic efficacy of lurasidone in the treatment of schizophrenia

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OBJECTIVE

To conduct a comprehensive pharmacoeconomic evaluation of lurasidone for the treatment of patients with schizophrenia under Russian healthcare system conditions and inclusion in EDL (Essential Drugs List) and Medication List for the Certain Categories of Citizens.

MATERIAL AND METHODS

A retrospective study of lurasidone in the treatment of patients with schizophrenia was performed. Methods of pharmacoeconomic analysis were: cost analysis, budget impact analysis and cost-effectiveness analysis.

RESULTS

Use of lurasidone for the treatment of patients with schizophrenia requires 50.04% less costs than the use of paliperidone and 46.69% less costs than the use of sertindole allowing to provide additional therapies to 100.1 and 87.6% of patients, respectively. The cost minimization analysis results are stable when prices fluctuate in the range of ±30%. Considering the current volume of antipsychotic drug supply, replacing 100% of paliperidone with lurasidone from the first year will reduce the cost of antipsychotics for patients who received paliperidone by 39.79 or by 360.81 million rubles over 3 years. Replacing 100% of sertindole with lurasidone from the first year will reduce the cost of antipsychotics for patients who received sertindole by 37.21 or 173.87 million rubles over 3 years. The results of the budget impact analysis are resistant to changes in prices for compared drugs in a wide range.

CONCLUSION

Lurasidone is a more effective drug for treatment of schizophrenia from a pharmacoeconomic point of view in comparison with paliperidone and sertindole. With comparative efficacy with paliperidone and sertindole the use of lurasidone can significantly reduce the burden on budget of state programs of compensation for certain categories of citizens.

Keywords:

schizophrenia

second generation antipsychotics

lurasidone

paliperidone

sertindole

minimization of expenses

analysis of budget impact

clinical and economic analysis

Authors:

Zyryanov S.K.

Peoples’ Friendship University of Russia (RUDN University)

Dyakov I.N.

Mechnikov Research Institute of vaccines and serums;
Scientific and Practical Center for Research of Problems of Rational Pharmacotherapy and Pharmacoeconomics

Juperin A.A.

Russian Medical Academy of Continuous Professional Education

Egorova D.A.

Russian Medical Academy of Continuous Professional Education

Mosolova E.S.

Lomonosov Moscow State University

Received:

23.03.2020

Accepted:

13.04.2020

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