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Sychev D.A.

Russian Medical Academy of Continuous Professional Education, Ministry of Health of the Russia, Moscow, Russia

Shprakh V.V.

Irkutskiĭ gosudarstvennyĭ institut usovershenstvovaniia vracheĭ

Kitaeva E.Yu.

Irkutsk State Medical Academy of Postgraduate Education — Branch Campus of the Federal State Budgetary Educational Institution of Further Professional Education «Russian Medical Academy of Continuous Professional Education», Irkutsk, Russia

Mirzaev K.B.

Russian Medical Academy of Continuous Professional Education, Moscow, Russia

Mickhalevich I.M.

Irkutsk State Medical Academy of Postgraduate Education — Branch Campus of the Federal State Budgetary Educational Institution of Further Professional Education «Russian Medical Academy of Continuous Professional Education», Irkutsk, Russia

Genetic and non-genetic factors of laboratory resistance to clopidogrel in patients with ischemic stroke

Authors:

Sychev D.A., Shprakh V.V., Kitaeva E.Yu., Mirzaev K.B., Mickhalevich I.M.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2019;119(3‑2): 45‑52

DOI: 10.17116/jnevro201911903245

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GENETIC AND NON-GENETIC FACTORS OF LABORATORY RESISTANCE TO CLOPIDOGREL IN PATIENTS WITH ISCHEMIC STROKE
GENETIC AND NON-GENETIC FACTORS OF LABORATORY RESISTANCE TO CLOPIDOGREL IN PATIENTS WITH ISCHEMIC STROKE

To cite this article:

Sychev DA, Shprakh VV, Kitaeva EYu, Mirzaev KB, Mickhalevich IM. Genetic and non-genetic factors of laboratory resistance to clopidogrel in patients with ischemic stroke. S.S. Korsakov Journal of Neurology and Psychiatry. 2019;119(3‑2):45‑52. (In Russ.)
https://doi.org/10.17116/jnevro201911903245

Подписка 2025-2 (S.S. Korsakov Journal of Neurology and Psychiatry (special issues))
 
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To identify clinical and pharmacogenetic predictors of the efficacy of clopidogrel in patients with AI based on CYP2C19 and ABCB1 genotyping. Material and methods. Clinical and laboratory examinations were performed in 121 patients with AI, and CYP2C19 polymorphisms (CYP2C19*2 (G681A, rs4244285), CYP2C19*3 (G363A, rs4986893), CYP2C19*17 (C806T, rs12248560), ABCB1 (C3435T, rs1045642), associated with a disturbance of antiplatelet action of clopidogrel. The carriage of polymorphic markers of the studied genes was determined by the method of polymerase chain reaction in real time. Results and conclusion. In the group with laboratory resistance to clopidogrel, women prevailed (p<0.0001), atherothrombotic subtype was 80% (p=0.0384), the frequency of obesity ischemic stroke was 60% (p<0.0001). Univariate analysis of variance of CYP2C19 polymorphisms CYP2C19 (CYP2C19*2 (G681A, rs4244285), CYP2C19*3 (G363A, rs4986893), CYP2C19*17 (C806T, rs12248560), ABCB1 (C3435T, rs1045642) in patients with ischemic stroke, demonstrated a significant effect of CYP2C19 genotypes on the indicators of residual reactivity of platelets.

Keywords:

ischemic stroke
pharmacogenetics
CYP2C19 gene
ABCB1 gene
polymorphism
clopidogrel

Authors:

Sychev D.A.

Russian Medical Academy of Continuous Professional Education, Ministry of Health of the Russia, Moscow, Russia

Shprakh V.V.

Irkutskiĭ gosudarstvennyĭ institut usovershenstvovaniia vracheĭ

Kitaeva E.Yu.

Irkutsk State Medical Academy of Postgraduate Education — Branch Campus of the Federal State Budgetary Educational Institution of Further Professional Education «Russian Medical Academy of Continuous Professional Education», Irkutsk, Russia

Mirzaev K.B.

Russian Medical Academy of Continuous Professional Education, Moscow, Russia

Mickhalevich I.M.

Irkutsk State Medical Academy of Postgraduate Education — Branch Campus of the Federal State Budgetary Educational Institution of Further Professional Education «Russian Medical Academy of Continuous Professional Education», Irkutsk, Russia

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