The role of stress factors and genetic predisposition in the development of stroke in patients with essential hypertension

Moskalenko M.I.

Belgorod National Research University, Belgorod, Russia

Ponomarenko I.V.

KGBUZ «Altai Regional Cardiological Dispensary», Barnaul, Russia

Polonikov A.V.

Kafedra biologii, meditsinskoĭ genetiki i kologii Kurskogo gosudarstvennogo meditsinskogo universiteta, Kursk

Zhernakova N.I.

Belgorod National Research University, Belgorod, Russia

Efremova O.A.

Belgorod National Research University, Belgorod, Russia

Churnosov M.I.

Kafedra mediko-biologicheskikh distsiplin Belgorodskogo gosudarstvennogo natsional'nogo issledovatel'skogo universiteta

The role of stress factors and genetic predisposition in the development of stroke in patients with essential hypertension

Authors:

Moskalenko M.I., Ponomarenko I.V., Polonikov A.V., Zhernakova N.I., Efremova O.A., Churnosov M.I.

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Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2019;119(3‑2): 11‑17

DOI: 10.17116/jnevro201911903211

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To cite this article:

Moskalenko MI, Ponomarenko IV, Polonikov AV, Zhernakova NI, Efremova OA, Churnosov MI. The role of stress factors and genetic predisposition in the development of stroke in patients with essential hypertension. S.S. Korsakov Journal of Neurology and Psychiatry. 2019;119(3‑2):11‑17. (In Russ.)
https://doi.org/10.17116/jnevro201911903211

Подписка 2025-2 (S.S. Korsakov Journal of Neurology and Psychiatry (special issues))

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To study the interaction of polymorphic markers of matrix metalloproteinases (MMP) and chronic stress in the development of stroke associated with hypertension. Material and methods. A total of 830 patients, including 303 patients with ischemic stroke associated with essential hypertension (EH) and 527 patients with EH without stroke, were examined. The study of metalloproteinases SNP was carried out using real-time PCR. The functional significance and influence of polymorphic loci on gene expression was studied using of HaploReg (v4.1) (http://archive.broadinstitute.org) and GTEx-portal (http://www.gtexportal.org). Results and conclusion. An association of the genotype GG (rs11568818) of MMP7 with a high risk of stroke in patients exposed to regular stress (OR=1.71) was observed. It was found that allele 5A and genotype 5A/5A (rs3025058) of MMP3 had a protective effect on the development of stroke in patients without regular stress in the anamnesis (OR=0.73 and OR=0.60, respectively). Those SNPs are localized in the region of histone proteins H3K4me1 and H3K4me3, in the region of hypersensitivity to DNase-1, in the region of binding of regulatory proteins and transcription factors. The polymorphic locus rs11568818 is associated with the expression level of MMP7.

Keywords:

ischemic stroke

matrix metalloproteinases (MMP)

single nucleotide polymorphism

stress

Authors:

Moskalenko M.I.

Belgorod National Research University, Belgorod, Russia

Ponomarenko I.V.

KGBUZ «Altai Regional Cardiological Dispensary», Barnaul, Russia

Polonikov A.V.

Kafedra biologii, meditsinskoĭ genetiki i kologii Kurskogo gosudarstvennogo meditsinskogo universiteta, Kursk

Zhernakova N.I.

Belgorod National Research University, Belgorod, Russia

Efremova O.A.

Belgorod National Research University, Belgorod, Russia

Churnosov M.I.

Kafedra mediko-biologicheskikh distsiplin Belgorodskogo gosudarstvennogo natsional'nogo issledovatel'skogo universiteta

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