A clinical and genetic analysis of risk factors for the development of acute and chronic cerebral ischemia

Anisimova A.V.

GBOU VPO "Rossiĭskiĭ natsional'nyĭ issledovatel'skiĭ meditsinskiĭ universitet im. N.I. Pirogova", Moskva

Gunchenko A.S.

Pirogov Russian National Research Medical University, Moscow, Russia

Ikonnikova A.Yu.

Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia

Galkin S.S.

GBOU VPO "Rossiĭskiĭ natsional'nyĭ issledovatel'skiĭ meditsinskiĭ universitet im. N.I. Pirogova", Moskva

Avdonina M.A.

Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia

Nasedkina T.V.

Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia

A clinical and genetic analysis of risk factors for the development of acute and chronic cerebral ischemia

Authors:

Anisimova A.V., Gunchenko A.S., Ikonnikova A.Yu., Galkin S.S., Avdonina M.A., Nasedkina T.V.

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Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2019;119(3‑2): 62‑67

DOI: 10.17116/jnevro201911903262

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To cite this article:

Anisimova AV, Gunchenko AS, Ikonnikova AYu, Galkin SS, Avdonina MA, Nasedkina TV. A clinical and genetic analysis of risk factors for the development of acute and chronic cerebral ischemia. S.S. Korsakov Journal of Neurology and Psychiatry. 2019;119(3‑2):62‑67. (In Russ.)
https://doi.org/10.17116/jnevro201911903262

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To study the association between polymorphic markers in the ACE, SERPINE1, FGB, F5, F7, F12, GP1BA, GPIIIa, MTHFR, CYP11B2, PON1, PON2, NOS2, NOS2, HIFla, LTA, ALOX5AP genes and clinical characteristics of acute and chronic forms of circulatory disorders of the brain. Material and methods. The analysis of polymorphic variants in ACE, FGB, F5, F7, F12, GP1BA, GPIIIa, SERPINE1, MTHFR, CYP11B2, PON1, PON2, NOS2, NOS3, PDE4D, HIF1a, LTA, ALOX5AP in 81 patients with chronic cerebral ischemia (CCI) and 69 patients with ischemic stroke (IS), and their interrelation with clinical manifestations of disease were investigated. Results and conclusion. The association between the T/T genotype of the PDE4D SNP 83C>T polymorphism and a rapid progression of hypertensive disease (GB) was revealed (OR=6.22, CI=1.86—20.79, p=0.0036) in the group of patients with CCI. The association of the allele D and the DD genotype of the ACE (I>D, rs1799752) with cardioembolic stroke (OR=2.67, 95% CI=1.23—5.8, p=0.02 and OR=7.14, 95% CI=1.72—29.69, p=0.0057) was found. When comparing subgroups of patients with different degrees of stenosis of brachiocephalic arteries (BCA), the association of the allele C and the TC genotype of the GP1BA (rs2243093, –5T/C) with BCA occlusion and expressed hemodynamically significant stenosis (>75%) was revealed (OR=3.39, 95% CI=1.12—10.25, p=0.03 and OR=4.44, 95% CI=1.27—15.54, p=0.023, respectively). Thus, polymorphic markers in PDE4D, ACE, GP1BA in combination with certain clinical characteristics are risk factors for the progression of CCI and development of IS.

Keywords:

stroke

chronic cerebral ischemia

risk factors

PDE4D

ACE

GP1BA

Authors:

Anisimova A.V.

GBOU VPO "Rossiĭskiĭ natsional'nyĭ issledovatel'skiĭ meditsinskiĭ universitet im. N.I. Pirogova", Moskva

Gunchenko A.S.

Pirogov Russian National Research Medical University, Moscow, Russia

Ikonnikova A.Yu.

Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia

Galkin S.S.

GBOU VPO "Rossiĭskiĭ natsional'nyĭ issledovatel'skiĭ meditsinskiĭ universitet im. N.I. Pirogova", Moskva

Avdonina M.A.

Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia

Nasedkina T.V.

Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia

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