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Popova E.V.

Kafedra nervnykh bolezneĭ fakul'teta poslevuzovskogo professional'nogo obrazovaniia vracheĭ Moskovskoĭ meditsinskoĭ akademii im. I.M. Sechenova

The use of alemtuzumab after non-selective immunosuppression in a patient with highly active rapidly progressive remitting multiple sclerosis

Authors:

Popova E.V.

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Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2019;119(2‑2): 116‑120

DOI: 10.17116/jnevro201911922116

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To cite this article:

Popova EV. The use of alemtuzumab after non-selective immunosuppression in a patient with highly active rapidly progressive remitting multiple sclerosis. S.S. Korsakov Journal of Neurology and Psychiatry. 2019;119(2‑2):116‑120. (In Russ.)
https://doi.org/10.17116/jnevro201911922116

 
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This article presents a clinical case of a patient with aggressive multiple sclerosis treated with alemtuzumab after non-selective immunosuppression.

Keywords:

multiple sclerosis
alemtuzumab
mitoxantrone
highly active multiple sclerosis
rapidly progressive multiple sclerosis

Authors:

Popova E.V.

Kafedra nervnykh bolezneĭ fakul'teta poslevuzovskogo professional'nogo obrazovaniia vracheĭ Moskovskoĭ meditsinskoĭ akademii im. I.M. Sechenova

List of references:

  1. Sorensen P. New management algorithms in multiple sclerosis. Current Opinion in Neurology. 2014;27(3):246-259. https://doi.org/10.1097/wco.0000000000000096
  2. Freedman M. Insights into the Mechanisms of the Therapeutic Efficacy of Alemtuzumab in Multiple Sclerosis. Journal of Clinical & Cellular Immunology. 2013;04(04):152. https://doi.org/10.4172/21559899.1000152
  3. Alifirova VM, Bisaga GN, Boyko AN, Bryukhov VV, Davidovskay MV, Zakharova EV, Zakharova MN, Popova EV, Malkova NA, Salogub GN, Sivertseva SA, Troshina EA, Hachanova NV, Schmidt TE. Clinical guidelines for the use of the drug alemtuzumab (Lemtrada). Zhurnal Nevrologii i Psihiatrii im. S.S. Korsakova. 2017;117(2):115-126. (In Russ.) https://doi.org/10.17116/jnevro201711722115-126
  4. Polman CH, Reingold SC, Banwell B, Clanet M, Cohen JA, Filippi M, Fujihara K, Havrdova E, Hutchinson M, Kappos L, Lublin FD, Montalban X, O’Connor P, Sandberg-Wollheim M, Thompson AJ, Waubant E, Weinshenker B, Wolinsky JS. Diagnostic criteria for multiple sclerosis: 2010 revisions to the McDonald criteria. Annals of Neurology. 2011;69(2):292-302. https://doi.org/10.1002/ana.22366
  5. Le Page E, Deburghgraeve V, Lester M-A. Alemtuzumab as rescue therapy in a cohort of 16 aggressive multiple sclerosis patients previously treated by Mitoxantrone: an observational study. J Neurol. 2015;262(4):1024-1034. https://doi.org/10.1007/s00415-015-7653-3

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