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Fursova A.Zh.

Novosibirsk State Regional Hospital;
Novosibirsk State Medical University

Zubkova M.Yu.

Novosibirsk State Regional Hospital;
Novosibirsk State Medical University

Vasilyeva M.A.

Novosibirsk State Regional Clinical Hospital;
Novosibirsk State Medical University

Karlash Yu.A.

Novosibirsk State Regional Hospital;
Novosibirsk State Medical University

Derbeneva A.S.

Novosibirsk State Regional Hospital;
Novosibirsk State Medical University

Optical coherence tomography angiography in the diagnosis of multiple sclerosis

Authors:

Fursova A.Zh., Zubkova M.Yu., Vasilyeva M.A., Karlash Yu.A., Derbeneva A.S.

More about the authors

Journal: Russian Annals of Ophthalmology. 2024;140(2): 63‑70

DOI: 10.17116/oftalma202414002163

Views: 703

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To cite this article:

Fursova AZh, Zubkova MYu, Vasilyeva MA, Karlash YuA, Derbeneva AS. Optical coherence tomography angiography in the diagnosis of multiple sclerosis. Russian Annals of Ophthalmology. 2024;140(2):63‑70. (In Russ.)
https://doi.org/10.17116/oftalma202414002163

Подписка 2025 (Russian Annals of Ophthalmology)
 
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PURPOSE

This study analyzes the main changes in retinal microcirculation in patients with multiple sclerosis (MS) and their relationship with the type of disease course.

MATERIAL AND METHODS

159 patients (318 eyes) were examined. The groups were formed according to the type of course and duration of MS: group 1 — 37 patients (74 eyes; 23.27%) with relapsing-remitting MS (RRMS) less than 1 year; group 2 — 47 patients (94 eyes; 29.56%) with RRMS from 1 year to 10 years; group 3 — 44 patients (86 eyes; 27.05%) with RRMS >10 years; group 4 — 32 patients (64 eyes; 20.12%) with secondary progressive MS (SPMS). Subgroups A and B were allocated within each group depending on the absence or presence of optic neuritis (ON). Patients underwent standard ophthalmological examination, including optical coherence tomography angiography (OCTA).

RESULTS

A decrease in the vessel density (wiVD) and perfusion density (wiPD) in the macular and peripapillary regions was revealed, progressing with the duration of the disease and with its transition to the progressive type. The minimum values were observed in patients with SPMS (group 4), with the most pronounced in the subgroup with ON (wiVD = 16.06±3.65 mm/mm2, wiPD = 39.38±9.46%, ppwiPD = 44.06±3.09%, ppwiF = 0.41±0.05).

CONCLUSION

OCTA provides the ability to detect subclinical vascular changes and can be considered a comprehensive, reliable method for early diagnosis and monitoring of MS progression.

Keywords:

multiple sclerosis
optical coherence tomography angiography
optic neuritis
expanded disability status scale
retinal microcirculation

Authors:

Fursova A.Zh.

Novosibirsk State Regional Hospital;
Novosibirsk State Medical University

Zubkova M.Yu.

Novosibirsk State Regional Hospital;
Novosibirsk State Medical University

Vasilyeva M.A.

Novosibirsk State Regional Clinical Hospital;
Novosibirsk State Medical University

Karlash Yu.A.

Novosibirsk State Regional Hospital;
Novosibirsk State Medical University

Derbeneva A.S.

Novosibirsk State Regional Hospital;
Novosibirsk State Medical University

Received:

04.03.2024

Accepted:

22.03.2024

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