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Sviridova A.A.
N.I. Pirogov Russian National Research Medical University;
Federal Center of Cerebrovascular Pathology and Stroke
Kabaeva A.R.
Pirogov Russian National Research Medical University, Moscow, Russia
Rogovsky V.S.
Pirogov Russian National Research Medical University, Moscow, Russia
Kozhieva M.Kh.
Pirogov Russian National Research Medical University, Moscow, Russia
Melnikov M.V.
Pirogov Russian National Research Medical University;
Federal Center of Brain Research and Neurotechnologies of FMBA;
Institute of Immunology of FMBA
Boyko A.N.
N.I. Pirogov Russian National Research Medical University;
Federal Center for Cerebrovascular Pathology and Stroke
Norepinephrine and intestinal microbiome in the early stages of demyelination: clinical-immunological parallels
Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2019;119(10‑2): 28‑34
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To cite this article:
Sviridova AA, Kabaeva AR, Rogovsky VS, Kozhieva MKh, Melnikov MV, Boyko AN. Norepinephrine and intestinal microbiome in the early stages of demyelination: clinical-immunological parallels. S.S. Korsakov Journal of Neurology and Psychiatry.
2019;119(10‑2):28‑34. (In Russ.)
https://doi.org/10.17116/jnevro201911910228
Biogenic amines are key mediators of neuroimmune interaction and may influence on multiple sclerosis (MS) pathogenesis and MS course. At the same time, the role of biogenic amines in immunoregulation of early stages of demyelination, in particular clinically isolated syndrome (CIS) and radiologically isolated syndrome (RIS) is still unclear. This literature review addresses a role of norepinephrine in the regulation of neuroimmune interactions in the early stages of the demyelination. Neuropsychological disorders, immunological characteristics, gut-brain axis as well as the role of norepinephrine in these interactions in patients with CIS, RIS and early MS are discussed.
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Authors:
Sviridova A.A.
N.I. Pirogov Russian National Research Medical University;
Federal Center of Cerebrovascular Pathology and Stroke
Kabaeva A.R.
Pirogov Russian National Research Medical University, Moscow, Russia
Rogovsky V.S.
Pirogov Russian National Research Medical University, Moscow, Russia
Kozhieva M.Kh.
Pirogov Russian National Research Medical University, Moscow, Russia
Melnikov M.V.
Pirogov Russian National Research Medical University;
Federal Center of Brain Research and Neurotechnologies of FMBA;
Institute of Immunology of FMBA
Boyko A.N.
N.I. Pirogov Russian National Research Medical University;
Federal Center for Cerebrovascular Pathology and Stroke
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