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Sviridova A.A.

N.I. Pirogov Russian National Research Medical University;
Federal Center of Cerebrovascular Pathology and Stroke

Kabaeva A.R.

Pirogov Russian National Research Medical University, Moscow, Russia

Rogovsky V.S.

Pirogov Russian National Research Medical University, Moscow, Russia

Kozhieva M.Kh.

Pirogov Russian National Research Medical University, Moscow, Russia

Melnikov M.V.

Pirogov Russian National Research Medical University;
Federal Center of Brain Research and Neurotechnologies of FMBA;
Institute of Immunology of FMBA

Boyko A.N.

N.I. Pirogov Russian National Research Medical University;
Federal Center for Cerebrovascular Pathology and Stroke

Norepinephrine and intestinal microbiome in the early stages of demyelination: clinical-immunological parallels

Authors:

Sviridova A.A., Kabaeva A.R., Rogovsky V.S., Kozhieva M.Kh., Melnikov M.V., Boyko A.N.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2019;119(10‑2): 28‑34

DOI: 10.17116/jnevro201911910228

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To cite this article:

Sviridova AA, Kabaeva AR, Rogovsky VS, Kozhieva MKh, Melnikov MV, Boyko AN. Norepinephrine and intestinal microbiome in the early stages of demyelination: clinical-immunological parallels. S.S. Korsakov Journal of Neurology and Psychiatry. 2019;119(10‑2):28‑34. (In Russ.)
https://doi.org/10.17116/jnevro201911910228

 
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Biogenic amines are key mediators of neuroimmune interaction and may influence on multiple sclerosis (MS) pathogenesis and MS course. At the same time, the role of biogenic amines in immunoregulation of early stages of demyelination, in particular clinically isolated syndrome (CIS) and radiologically isolated syndrome (RIS) is still unclear. This literature review addresses a role of norepinephrine in the regulation of neuroimmune interactions in the early stages of the demyelination. Neuropsychological disorders, immunological characteristics, gut-brain axis as well as the role of norepinephrine in these interactions in patients with CIS, RIS and early MS are discussed.

Keywords:

norepinephrine
neuroimmune interactions
gut microbiota
clinically isolated syndrome
radiologically isolated syndrome
norepinephrine
neuroimmune interactions
gut microbiota
clinically isolated syndrome
radiologically isolated syndrome

Authors:

Sviridova A.A.

N.I. Pirogov Russian National Research Medical University;
Federal Center of Cerebrovascular Pathology and Stroke

Kabaeva A.R.

Pirogov Russian National Research Medical University, Moscow, Russia

Rogovsky V.S.

Pirogov Russian National Research Medical University, Moscow, Russia

Kozhieva M.Kh.

Pirogov Russian National Research Medical University, Moscow, Russia

Melnikov M.V.

Pirogov Russian National Research Medical University;
Federal Center of Brain Research and Neurotechnologies of FMBA;
Institute of Immunology of FMBA

Boyko A.N.

N.I. Pirogov Russian National Research Medical University;
Federal Center for Cerebrovascular Pathology and Stroke

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