Norepinephrine and intestinal microbiome in the early stages of demyelination: clinical-immunological parallels

Sviridova A.A.; Kabaeva A.R.; Rogovsky V.S.; Kozhieva M.Kh.; Melnikov M.V.; Boyko A.N.

doi:https://doi.org/10.17116/jnevro201911910228

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Abstract:

Biogenic amines are key mediators of neuroimmune interaction and may influence on multiple sclerosis (MS) pathogenesis and MS course. At the same time, the role of biogenic amines in immunoregulation of early stages of demyelination, in particular clinically isolated syndrome (CIS) and radiologically isolated syndrome (RIS) is still unclear. This literature review addresses a role of norepinephrine in the regulation of neuroimmune interactions in the early stages of the demyelination. Neuropsychological disorders, immunological characteristics, gut-brain axis as well as the role of norepinephrine in these interactions in patients with CIS, RIS and early MS are discussed.

Keywords:

norepinephrine

neuroimmune interactions

gut microbiota

clinically isolated syndrome

radiologically isolated syndrome

norepinephrine

neuroimmune interactions

gut microbiota

clinically isolated syndrome

radiologically isolated syndrome

Authors:

Sviridova A.A.

N.I. Pirogov Russian National Research Medical University;
Federal Center of Cerebrovascular Pathology and Stroke

SPIN RSCI: 6291-3236
Scopus AuthorID: 57209272018
ORCID: 0000-0003-1086-9052

Kabaeva A.R.

Pirogov Russian National Research Medical University, Moscow, Russia

SPIN RSCI: 3952-3519
Scopus AuthorID: 57195808362
ORCID: 0000-0002-0982-8520

Rogovsky V.S.

Pirogov Russian National Research Medical University, Moscow, Russia

SPIN RSCI: 8319-1426
Scopus AuthorID: 37031850500
ORCID: 0000-0002-3682-6571

Kozhieva M.Kh.

Pirogov Russian National Research Medical University, Moscow, Russia

Scopus AuthorID: 57200325637
ORCID: 0000-0001-6665-8655

Melnikov M.V.

Pirogov Russian National Research Medical University;
Federal Center of Brain Research and Neurotechnologies of FMBA;
Institute of Immunology of FMBA

SPIN RSCI: 6636-6419
Scopus AuthorID: 57221797118
ORCID: 0000-0001-6880-3668

Boyko A.N.

N.I. Pirogov Russian National Research Medical University;
Federal Center for Cerebrovascular Pathology and Stroke

SPIN RSCI: 9921-9109
Scopus AuthorID: 7102247663
ORCID: 0000-0002-2975-4151

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