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Khachanova N.V.

Burdenko Neurosurgical Institute, Moscow, Russia

Bakhtiiarova K.Z.

Bashkirskiĭ gosudarstvennyĭ meditsinskiĭ universitet, Ufa

Boĭko A.N.

KGBUZ "Krasnoiarskiĭ kraevoĭ Tsentr po profilaktike i bor'be so SPID i infektsionnymi zabolevaniiami"

Vlasov Ia.V.

Kafedra nevrologii i neĭrokhirurgii Samarskogo gosudarstvennogo meditsinskogo universiteta

Davydovskaya M.V.

Research and Practical Centre for Clinical Investigations and Evaluation of Medical Technologies, Moscow Health Department, Moscow, Russia

Evdoshenko E.P.

Sankt-Peterburgskoe GBUZ "Gorodskaia klinicheskaia bol'nitsa #31", Sankt-Peterburgskiĭ gorodskoĭ Tsentr rasseiannogo skleroza i autoimmunnykh zabolevaniĭ, Sankt-Peterburg

Zakharova M.N.

Nauchnyĭ tsentr nevrologii RAMN, Moskva

Malkova N.A.

Novosibirskiĭ okruzhnoĭ tsentr rasseiannogo skleroza

Sivertseva S.A.

Tiumenskiĭ oblastnoĭ tsentr rasseiannogo skleroza

Spirin N.N.

Kafedra nervnykh bolezneĭ i meditsinskoĭ genetiki s kursom neĭrokhirurgii Iaroslavskoĭ gosudarstvennoĭ meditsinskoĭ akademii

Stoliarov I.D.

Shmidt T.E.

Kafedra nervnykh bolezneĭ Pervogo Moskovskogo gosudarstvennogo meditsinskogo universiteta im. I.M. Sechenova, Moskva

Khabirov F.A.

Kazanskaia gosudarstvennaia meditsinskaia akademiia Minzdravsotsrazvitiia Rossii;
Respublikanskiĭ kliniko-diagnosticheskiĭ tsentr po demieliniziruiushchim zabolevaniiam Ministerstva zdravookhraneniia Respubliki Tatarstan, Kazan'

Provision of alemtuzumab safety is one of the main components of pharmacovigilance

Authors:

Khachanova N.V., Bakhtiiarova K.Z., Boĭko A.N., Vlasov Ia.V., Davydovskaya M.V., Evdoshenko E.P., Zakharova M.N., Malkova N.A., Sivertseva S.A., Spirin N.N., Stoliarov I.D., Shmidt T.E., Khabirov F.A.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2018;118(8‑2): 82‑87

DOI: 10.17116/jnevro201811808282

Read: 1076 times

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Table of contents

PROVISION OF ALEMTUZUMAB SAFETY IS ONE OF THE MAIN COMPONENTS OF PHARMACOVIGILANCE
PROVISION OF ALEMTUZUMAB SAFETY IS ONE OF THE MAIN COMPONENTS OF PHARMACOVIGILANCE

To cite this article:

Khachanova NV, Bakhtiiarova KZ, Boĭko AN, et al. . Provision of alemtuzumab safety is one of the main components of pharmacovigilance. S.S. Korsakov Journal of Neurology and Psychiatry. 2018;118(8‑2):82‑87. (In Russ.)
https://doi.org/10.17116/jnevro201811808282

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова. Спецвыпуски (S.S. Korsakov Journal of Neurology and Psychiatry (special issues))
 
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Abstract:

Modern multiple sclerosis therapy with disease-modifying drugs is characterized by the risks of dangerous infectious complications. In the last 5 years, there have been several reports of severe, sometimes lethal, listeriosis infection in patients treated with alemtuzumab. This article presents a clinical case of lethal listeriosis meningoencephalitis, which developed within 7 days after the completion of the first cycle of alemtuzumab therapy. In January 2018, a meeting of the expert Council was held, at which the clinical recommendations published in 2017 were revised and updated.

Keywords:

multiple sclerosis
listeriosis
alemtuzumab

Authors:

Khachanova N.V.

Burdenko Neurosurgical Institute, Moscow, Russia

Bakhtiiarova K.Z.

Bashkirskiĭ gosudarstvennyĭ meditsinskiĭ universitet, Ufa

Boĭko A.N.

KGBUZ "Krasnoiarskiĭ kraevoĭ Tsentr po profilaktike i bor'be so SPID i infektsionnymi zabolevaniiami"

Vlasov Ia.V.

Kafedra nevrologii i neĭrokhirurgii Samarskogo gosudarstvennogo meditsinskogo universiteta

Davydovskaya M.V.

Research and Practical Centre for Clinical Investigations and Evaluation of Medical Technologies, Moscow Health Department, Moscow, Russia

Evdoshenko E.P.

Sankt-Peterburgskoe GBUZ "Gorodskaia klinicheskaia bol'nitsa #31", Sankt-Peterburgskiĭ gorodskoĭ Tsentr rasseiannogo skleroza i autoimmunnykh zabolevaniĭ, Sankt-Peterburg

Zakharova M.N.

Nauchnyĭ tsentr nevrologii RAMN, Moskva

Malkova N.A.

Novosibirskiĭ okruzhnoĭ tsentr rasseiannogo skleroza

Sivertseva S.A.

Tiumenskiĭ oblastnoĭ tsentr rasseiannogo skleroza

Spirin N.N.

Kafedra nervnykh bolezneĭ i meditsinskoĭ genetiki s kursom neĭrokhirurgii Iaroslavskoĭ gosudarstvennoĭ meditsinskoĭ akademii

Stoliarov I.D.

Shmidt T.E.

Kafedra nervnykh bolezneĭ Pervogo Moskovskogo gosudarstvennogo meditsinskogo universiteta im. I.M. Sechenova, Moskva

Khabirov F.A.

Kazanskaia gosudarstvennaia meditsinskaia akademiia Minzdravsotsrazvitiia Rossii;
Respublikanskiĭ kliniko-diagnosticheskiĭ tsentr po demieliniziruiushchim zabolevaniiam Ministerstva zdravookhraneniia Respubliki Tatarstan, Kazan'

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References:

  1. Khachanova NV, Davydovskaya MV, Evdoshenko EP. Updated risk stratification and risk management plan for Natalizumab-associated progressive multifocal leukoencephalopathyed. RMJ. 2017;13:3-7. (In Russ.)
  2. Rau D, Lang M, Harth A, Naumann M, Weber F, Tumani H, Bayas A. Listeria meningitis complicating alemtuzumab treatment in multiple sclerosis — report of two cases. Int J Mol Sci. 2015;16:14669-14676. https://doi.org/10.3390/ijms160714669
  3. Holmoy T, von der Lippe H, Leegaard TM. Listeria monocytogenes infection associated with alemtuzumab — a case for better preventive strategies. BMC Neurol. 2017;17:65-68. https://doi.org/10.1155/2014/358051
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  5. Coles A, Robertson N, Al-Araji A, Waller B, Brenner B, Mclean B, Gran B, Giovannoni G, Price S, Rashid W. Guidance on prevention of Listeria infection after alemtuzumab treatment of multiple sclerosis. https://www.theabn.org/media/Guidance%20on%20the%20prevention%20of%20Listeria%20infection%20after%20alemtuzumab%20treatment%20of%20multiple%20sclerosis.pdf
  6. Yushchuk ND, Karetkina GN, Klimov EA, Boytsov PV, Kelly EI, Malyshev NA, Mandzhiev GD, Revazyan NR, Serobyan AG, Solovyeva LJ, Sheberstov NB. Listeriosis of pregnancy: the role of infectious disease in the diagnosis and treatment. Topical issues of infectious pathology. 6th Congress of infectious diseases of the Republic of Belarus. 29—30 may 2014, Vitebsk, Republic of Belarus. (In Russ.)
  7. Tartakovsky IS. Listeria: role in human infectious pathology and laboratory diagnostics. Clinical Microbiology and antimicrobial chemotherapy. 2000;2(2):20-30. (In Russ.)
  8. Hernandez-Milian A, Payeras-Cifre A. What is new in listeriosis? Biomed Res Int. 2014;358051. https://doi.org/10.1155/2014/358051
  9. Maertens De NC, Devleesschauwer B., Angulo F.J. et al. The global burden of listeriosis: a systematic review and meta-analysis. Lancet Infect Dis. 2014;11:1073-1082. https://doi.org/10.1016/S1473-3099(14)70870-9
  10. Luchshev VI, Nikiforov VV, Burova SV, Tomilin YuN, Novikova LV, Pavlova AYu. Listeriosis. Medical case. 2005;2:71-76. (In Russ.)
  11. Nikolich-Zugich J, Li G, Uhrlaub JL, Renkema KR, Smithey MJ. Age-related changes in CD8 T cell homeostasis and immunity to infection. Semin Immunol. 2012;24:356-364. https://doi.org/10.1016/j.smim.2012.04.009
  12. Vazquez-Boland JA, Kuhn M, Berche P, Chakraborty T, Domínguez-Bernal G, Goebel W, González-Zorn B, Wehland J, Kreft J. Listeria pathogenesis and molecular virulence determinants. Clin Microbiol Rev. 2001;14:584-640. https://doi.org/10.1128/CMR.14.3.584-640.2001
  13. Zenewicz LA, Shen H. Innate and adaptive immune responses to Listeria monocytogenes: A short overview. Microbes Infect Inst Pasteur. 2007;9:1208-1215. https://doi.org/10.1016/j.micinf.2007.05.008
  14. Disson O, Lecuit M. Targeting of the central nervous system by Listeria monocytogenes. Virulence. 2012;3:213-221. https://doi.org/10.4161/viru.19586
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  18. Giovannoni G, Marta M, Davis A, Turner B, Gnanapavan S, Schmiere K. Switching patients at high risk of PML from natalizumab to another disease-modifying therapy. Pract Neurol. 2016;16:389-393. https://doi.org/10.1136/practneurol-2015-001355
  19. WHO (2014) Essential Medicines and Health Products: Pharmacovigilance. World Health Organization. http://www.who.int/medicines/areas/quality_safety/safety_efficacy/pharmvigi/en/
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