The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Login
EN
+7 (495) 482-4118
+7 (495) 482-4329
+8 800 250-18-12
  • (toll-free number for subscriptions)
    Mon-Fri from 10 a.m. to 6 p.m.

  • © 1998-2025
+7 (495) 482-43-29
EN
All journals
Journal
Year
Year
Search result: 0

Iakovleva O.V.

Russian Medical Academy of Continuous Professional Education, Centre of Extrapyramidal Disorders, Moscow, Russsia

Poluéktov M.G.

Kurs somnologii pri kafedre nervnykh bolezneĭ fakul'teta poslevuzovskogo professional'nogo obrazovaniia Moskovskoĭ meditsinskoĭ akademii im. I.M. Sechenova

Levin O.S.

Rossiĭskaia meditsinskaia akademiia poslediplomnogo obrazovaniia

Liashenko E.A.

Kafedra nevrologii Rossiĭskoĭ meditsinskoĭ akademii poslediplomnogo obrazovaniia, Moskva;
Tsentr kstrapiramidnykh zabolevaniĭ, Moskva

Sleep and wakefulness disorders in neurodegenerative diseases

Authors:

Iakovleva O.V., Poluéktov M.G., Levin O.S., Liashenko E.A.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2018;118(4‑2): 83‑91

DOI: 10.17116/jnevro20181184283

Read: 9897 times

Download PDF (RU)
Contact the author
Table of contents

SLEEP AND WAKEFULNESS DISORDERS IN NEURODEGENERATIVE DISEASES
SLEEP AND WAKEFULNESS DISORDERS IN NEURODEGENERATIVE DISEASES

To cite this article:

Iakovleva OV, Poluéktov MG, Levin OS, Liashenko EA. Sleep and wakefulness disorders in neurodegenerative diseases. S.S. Korsakov Journal of Neurology and Psychiatry. 2018;118(4‑2):83‑91. (In Russ.)
https://doi.org/10.17116/jnevro20181184283

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова. Спецвыпуски (S.S. Korsakov Journal of Neurology and Psychiatry (special issues))
МСФ на ЯМ
Использование инфографики авторами научных работ
Close metadata
Recommended articles:
Ventricular arrhythmias in patients with sleep apnea syndromes: what is the opti­mal therapy?. Russian Journal of Cardiology and Cardiovascular Surgery. 2024;(6):660-669
Neurochemical mechanisms of tremor in Parkinson’s disease. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(11):64-72
Clinical presentation and diagnosis of Parkinson’s disease in patients with schi­zophrenia spectrum diso­rders. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(11):73-80
Cognitive impairment in patients with Parkinson’s disease. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(11):81-90
Bladder dysfunction in patients with stages I—III of Parkinson’s disease. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(11):91-99
Chro­nic epidural spinal cord stimulation for gait impairments in Parkinson’s disease and atypical parkinsonism. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(11):100-112
Como­rbidity of depression and deme­ntia: epidemiological, biological and therapeutic aspe­cts. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(11):113-121
Carbonyl stress in meno­pausal women with inso­mnia. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(11):192-197
Subjective sleep quality evaluation in patients with neuromyelitis optica spectrum diso­rders. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(12):57-61
The rela­tionship between neuropsychological indi­cators and neuroimaging changes acco­rding to MRI morphometry in patients with Alzheimer’s disease and glaucoma. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(12):142-152
Abstract:

The article reviews the phenomenology of sleep and wakefulness disorders in Parkinson’s disease and Alzheimer’s disease. Degeneration of sleep and wakefulness centers, secondary effect of other symptoms of diseases and side-effects of drug therapy lead to a widespread prevalence of sleep and wakefulness disturbances in these patients. Along with the review of actual literature concerning mechanisms of development and clinical features of these disorders, the authors discuss principal methods for their treatment.

Keywords:

sleep
insomnia
excessive daytime sleepiness
REM behavior disorder
obstructive sleep apnea syndrome
restless legs syndrome
Parkinson’s disease
Alzheimer’s disease
melatonin

Authors:

Iakovleva O.V.

Russian Medical Academy of Continuous Professional Education, Centre of Extrapyramidal Disorders, Moscow, Russsia

Poluéktov M.G.

Kurs somnologii pri kafedre nervnykh bolezneĭ fakul'teta poslevuzovskogo professional'nogo obrazovaniia Moskovskoĭ meditsinskoĭ akademii im. I.M. Sechenova

Levin O.S.

Rossiĭskaia meditsinskaia akademiia poslediplomnogo obrazovaniia

Liashenko E.A.

Kafedra nevrologii Rossiĭskoĭ meditsinskoĭ akademii poslediplomnogo obrazovaniia, Moskva;
Tsentr kstrapiramidnykh zabolevaniĭ, Moskva

Close metadata

References:

  1. Ascherio A, Schwarzschild M. The epidemiology of Parkinson’s disease: risk factors and prevention. The Lancet Neurology. 2016;15(12):1257-1272. https://doi.org/10.1016/s1474-4422(16)30230-7
  2. Sosa-Ortiz A, Acosta-Castillo I, Prince M. Epidemiology of Dementias and Alzheimer’s Disease. Arch Med Res. 2012;43(8):600-608. https://doi.org/10.1016/j.arcmed.2012.11.003
  3. Babkina OV, Poluektov MG, Levin OS. The heterogeneity of daytime sleepiness in Parkinson’s disease. Zhurnal nevrologii ipsikhiatrii im. S.S. Korsakova. 2016;111:(6):60-70. (In Russ.) https://doi.org/10.17116/jnevro20161166260-70
  4. Rothman SM, Mattson MP. Sleep Disturbances in Alzheimer’s and Parkinson’s Diseases. Neuromolecular medicine. 2012;14(3):194-204. https://doi.org/10.1007/s12017-012-8181-2
  5. Fifel K, Vezoli J, Dzahini K., Claustrat B, Leviel V, Kennedy H, Procyk E, Dkhissi-Benyahya O, Gronfier C, Cooper HM. Editors: Ralph E. Mistlberger Alteration of Daily and Circadian Rhythms following Dopamine Depletion in MPTP Treated Non-Human Primates. PLoS ONE. 2014;9(1):86240. https://doi.org/10.1371/journal.pone.0086240
  6. Fronczek R, Overeem S, Lee SYY, Hegeman IM, van Pelt J, van Duinen SG, Lammers GJ, Swaab DF. Hypocretin (orexin) loss in Parkinson’s disease. Brain. 2007;130:1577-1585. https://doi.org/10.1016/j.neurobiolaging.2011.03.014
  7. Thannickal T, Lai Y, Siegel J. Hypocretin (orexin) cell loss in Parkinson’s disease. Brain. 2007;130(6):1586-1595. https://doi.org/10.1093/brain/awm097
  8. Iranzo A. Sleep in Neurodegenerative Diseases. Sleep Med Clin. 2016; 11(1):1-18. https://doi.org/10.1016/j.jsmc.2015.10.011
  9. Harkany T, Penke B, Luiten P. beta-Amyloid Excitotoxicity in Rat Magnocellular Nucleus Basalis: Effect of Cortical Deafferentation on Cerebral Blood Flow Regulation and Implications for Alzheimer’s Disease. Ann N Y Acad Sci. 2000;903(1 VASCULAR FACT):374-386. https://doi.org/10.1111/j.1749-6632.2000.tb06389.x
  10. Fronczek R, van Geest S, Frölich M, Overeem S, Roelandse FWC, Lammers GJ, Swaab DF. Hypocretin (orexin) loss in Alzheimer’s disease. Neurobiol Aging. 2012;33(8):1642-1650. https://doi.org/10.1016/j.neurobiolaging.2011.03.014
  11. Ding H, Liu S, Yuan Y, Lin Q, Chan P, Cai Y. Decreased expression of Bmal2 in patients with Parkinson’s disease. Neurosci Lett. 2011;499(3):186-188. https://doi.org/10.1016/j.neulet.2011.05.058
  12. Hood S, Amir S. Neurodegeneration and the Circadian Clock. Front Aging Neurosci. 2017;9. https://doi.org/10.3389/fnagi.2017.00170
  13. Wu Y-H, Fischer DF, Kalsbeek A, Garidou-Boof M-L, van der Vliet J, van Heijningen C, Liu R-Y, Zhou J-N, Swaab DF. Pineal clock gene oscillation is disturbed in Alzheimer’s disease, due to functional disconnection from the «master clock». The FASEB Journal. 2006;20(11):1874-1876. https://doi.org/10.1096/fj.05-4446fje
  14. Craig D, Hart D, Passmore A. Genetically Increased Risk of Sleep Disruption in Alzheimer’s Disease. Sleep. 2006;29(8):1003-1007. https://doi.org/10.1093/sleep/29.8.1003
  15. Levin OS, Fedorova NV. Bolezn’ Parkinsona. 2-e izd. M.: MEDpress-inform; 2012 (In Russ.)
  16. Boeve B, Silber M, Saper C, Ferman TJ, Dickson DW, Parisi JE, Benarroch EE, Ahlskog JE, Smith GE, Caselli RC, Tippman-Peikert M, Olson EJ, Lin S-C, Young T, Wszolek Z, Schenck CH, Mahowald MW, Castillo PR, Del Tredici K, Braak H. Pathophysiology of REM sleep behaviour disorder and relevance to neurodegenerative disease. Brain. 2007;130(11):2770-2788. https://doi.org/10.1093/brain/awm056
  17. Schenck C, Boeve B, Mahowald M. Delayed emergence of a parkinsonian disorder or dementia in 81% of older men initially diagnosed with idiopathic rapid eye movement sleep behavior disorder: a 16-year update on a previously reported series. Sleep Med. 2013;14(8):744-748. https://doi.org/10.1016/j.sleep.2012.10.009
  18. Frucht S, Rogers J, Greene P, Gordon M, Fahn S. Falling asleep at the wheel: Motor vehicle mishaps in persons taking pramipexole and ropinirole. Neurology. 1999;52(9):1908-1908. https://doi.org/10.1212/wnl.52.9.1908
  19. Arnulf I, Konofal E, Merino-Andreu M, Houeto JL, Mesnage V, Welter ML, Lacomblez L, Golmard JL, Derenne JP, Agid Y. Parkinson’s disease and sleepiness: An integral part of PD. Neurology. 2002;58(7):1019-1024. https://doi.org/10.1212/wnl.58.7.1019
  20. Nomura T, Inoue Y, Kobayashi M, Namba K, Nakashima K. Characteristics of obstructive sleep apnea in patients with Parkinson’s disease. J Neurol Sci. 2013;327(1-2):22-24. https://doi.org/10.1016/j.jns.2013.01.036
  21. Diederich N, Vaillant M, Leischen M, Mancuso G, Golinval S, Nati R, Schlesser M. Sleep apnea syndrome in Parkinson’s disease. A case-control study in 49 patients. Movement Disorders. 2005;20(11):1413-1418. https://doi.org/10.1002/mds.20624
  22. Most E, Aboudan S, Scheltens P, Van Someren E. Discrepancy Between Subjective and Objective Sleep Disturbances in Early- and Moderate-Stage Alzheimer Disease. The American Journal of Geriatric Psychiatry. 2012;20(6):460-467. https://doi.org/10.1097/jgp.0b013e318252e3ff
  23. Bliwise DL. Sleep disorders in Alzheimer’s disease and other dementias. Clin Cornerstone. 2004;6:16-28. https://doi.org/10.1016/s1098-3597(04)90014-2
  24. Hassainia F, Petit D, Nielsen T, Gauthier S, Montplaisir J. Quantitative EEG and Statistical Mapping of Wakefulness and REM Sleep in the Evaluation of Mild to Moderate Alzheimer’s Disease. Eur Neurol. 1997;37(4):219-224. https://doi.org/10.1159/000117446
  25. Yesavage J, Friedman L, Kraemer H, Noda A, Wicks D, Bliwise DL, Sheikh J, Tinklenberg J, Zarcone V. A Follow-Up Study of Actigraphic Measures in Home-Residing Alzheimer’s Disease Patients. J Geriatr Psychiatry Neurol. 1998;11(1):7-10. https://doi.org/10.1177/089198879801100103
  26. Cohen-Zion M, Stepnowsky C, Marler M, Shochat T, Kripke DF, Ancoli-Israel S. Changes in Cognitive Function Associated with Sleep Disordered Breathing in Older People. J Am Geriatr Soc. 2001;49(12):1622-1627. https://doi.org/10.1046/j.1532-5415.2001.t01-1-49270.x
  27. Onen F, Onen H. Obstructive sleep apnea and cognitive impairment in the elderly. Psychol Neuropsychiatr Vieil. 2010;8:163-169. https://doi.org/10.1684/pnv.2010.0219
  28. Pearson V, Allen R, Dean T, Gamaldo C, Lesage S, Earley C. Cognitive deficits associated with restless legs syndrome (RLS). Sleep Med. 2006;7(1):25-30. https://doi.org/10.1016/j.sleep.2005.05.006
  29. Schenck C, Garcia-Rill E, Skinner R, Anderson M, Mahowald M. A case of REM sleep behavior disorder with autopsy-confirmed alzheimer’s disease: postmortem brain stem histochemical analyses. Biol Psychiatry. 1996;40(5):422-425. https://doi.org/10.1016/0006-3223(96)00070-4
  30. Schenck C, Mahowald M, Anderson M, Silber M, Boeve B, Parisi J. Lewy body variant of alzheimer’s disease (AD) identified by postmortem ubiquitin staining in a previously reported case of AD associated with REM sleep behavior disorder. Biol Psychiatry. 1997;42(6):527-528. https://doi.org/10.1016/s0006-3223(97)00228-x
  31. Dowling G, Mastick J, Colling E, Carter J, Singer C, Aminoff M. Melatonin for sleep disturbances in Parkinson’s disease. Sleep Med. 2005;6(5):459-466. https://doi.org/10.1016/j.sleep.2005.04.004
  32. Medeiros C, Carvalhedo de Bruin PF, Lopes LA, Magalhães MC, de Lourdes Seabra M, Sales de Bruin VM. Effect of exogenous melatonin on sleep and motor dysfunction in Parkinson’s disease. J Neurol. 2007;254(4):459-464. https://doi.org/10.1007/s00415-006-0390-x
  33. Lyashenko ЕА, Levin OS, Poluektov MG. Melatonin in correction of REM-sleep behavior disorders in Parkinson’s disease. Zh Nevrol Psikhiatr im. S.S. Korsakova (Spec. viep). 2015;115(6):40-43. (In Russ.) https://doi.org/10.17116/jnevro20151156240-43
  34. de Jonghe A, Korevaar J, van Munster B, de Rooij S. Effectiveness of melatonin treatment on circadian rhythm disturbances in dementia. Are there implications for delirium? A systematic review. Int J Geriatr Psychiatry. 2010;25(12):1201-1208. https://doi.org/10.1002/gps.2454
  35. Postuma RB, Lang AE, Munhoz RP, Charland K, Pelletier A, Moscovich M, Filla L, Zanatta D, Romenets SR, Altman R, Chuang R, Shah B. Caffeine for treatment of Parkinson disease: A randomized controlled trial. Neurology. 2012;79(7):651-658. https://doi.org/10.1212/WNL.0b013e318263570d
  36. Neikrug AB, Liu L, Avanzino JA, Maglione JE, Natarajan L, Bradley L, Maugeri A, Corey-Bloom J, Palmer BW, Loredo JS, Ancoli-Israel S. Continuous positive airway pressure improves sleep and daytime sleepiness in patients with Parkinson disease and sleep apnea. Sleep. 2014;37(1):177-185. https://doi.org/10.5665/sleep.3332
  37. Terzaghi M, Spelta L, Minafra B, Rustioni V, Zangaglia R, Pacchetti C, Manni R. Treating sleep apnea in Parkinson’s disease with C-PAP: feasibility concerns and effects on cognition and alertness. Sleep Med. 2017;33:114-118. https://doi.org/10.1016/j.sleep.2017.01.009
  38. Gros P, Mery VP, Lafontaine AL, Robinson A, Benedetti A, Kimoff RJ, Kaminska M. Obstructive sleep apnea in Parkinson’s disease patients: effect of Sinemet CR taken at bedtime. Sleep Breath. 2016;20(1):205-212. https://doi.org/10.1007/s11325-015-1208-9
  39. Ancoli-Israel S, Palmer BW, Cooke JR, Corey-Bloom J, Fiorentino L, Natarajan L, Liu L, Ayalon L, He F, Loredo JS. Cognitive Effects of Treating Obstructive Sleep Apnea in Alzheimer’s Disease: A Randomized Controlled Study. Journal of the American Geriatrics Society. 2008;56(11):2076-2081. https://doi.org/10.1111/j.1532-5415.2008.01934.x
  40. Ju Y, McLeland J, Toedebusch CD, Xiong C, Fagan AM, Duntley SP, Morris JC, Holtzman DM. Sleep Quality and Preclinical Alzheimer Disease. JAMA Neurol. 2013;70(5):587. https://doi.org/10.1001/jamaneurol.2013.2334
Contact the author
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.

Email Confirmation

An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

Email Confirmation

Contact us
If you have any questions, complaints or suggestions, please use this feedback form.
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.
Submit Application

You can become an author of one of our magazines, send a request and we will consider it in during the day.

Name
Phone
E-mail
Message
Login
Registration
E-mail
Password
Forgot Password?

Log in to the site using your account in one of the services

Password recovery
E-mail
Login
Register

We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.