Objective. To determine the clinical significance of peripheral blood leukocyte indices in predicting the outcome of ischemic stroke (IS). Material and methods. Forty-five case histories of patients with IS were retrospectively analyzed (25 with a favorable, 20 with a fatal outcome of the disease). Index of blood leukocyte shift (IBLS) and index of the ratio of blood leukocytes and ESR (BLESR), which were calculated based on the results of the General analysis of peripheral blood collected during hospitalization, were chosen as markers of the severity of the condition and prognosis of the disease. The severity of neurological deficit was assessed on the NIHSS scale. Results. In patients with a favorable IS outcome, IBLS was 3.85±0.67, BLESR 2.47±1.22; the correlation coefficient of the severity of neurological deficit and IBLS with a favorable outcome was 0.21, which corresponds to a weak positive Cheddock’s association. In patients with unfavorable outcome, ISLC was 7.73±2.72, BLESR 3,39±1,54; correlation coefficient 0.55 (moderate Cheddock’s association). Conclusion. The probability of death increases at higher values of IBLS and BLESR. Average values of the indices in the unfavorable outcome exceed approximately 1.5—2 times those in the favorable outcome. Regression analysis between ISC and the severity of neurological deficits in case of death showed a moderate correlation: the higher the ISC and NIHSS values, the greater the probability of death. The results can help in IS outcome prognosis and the choice of correct tactics of treatment of the patient in the acute stage.