Apoptosis as a systemic adaptive mechanism in ischemic stroke

Sergeeva S.P.; Savin A.A.; Litvitsky P.F.; Lyundup A.V.; Kiseleva E.V.; Gorbacheva L.R.; Breslavich I.D.; Kucenko K.I.; Balyasin M.V.

doi:https://doi.org/10.17116/jnevro201811812238

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Abstract:

This paper presents a literature review considering the role and mechanism of apoptosis in the pathogenesis of ischemic stroke (IS). The authors introduce a new concept: the functional request of the patient as a set of external (the nature and intensity of rehabilitation measures, characteristics of everyday life, diet, etc.) and internal (genetic factors, internal picture of the disease, availability of rental and other psychological facilities and etc.) attributes. This concept allows a new angle in understanding the pathogenesis of IS and creates fundamental and clinical potential for more successful approaches to therapy and rehabilitation after IS.

Keywords:

ischemic stroke

apoptosis

neuroplasticity

neurodarvinism

rehabilitation

functional request

Authors:

Sergeeva S.P.

Sechenov First Moscow State Medical University, Moscow

ORCID: 0000-0002-0083-1213

Savin A.A.

Litvitsky P.F.

Chair of Hospital-Based Therapy №2, Chair of Pathophysiology of Medical Faculty, Sechenov First Moscow State Medical University of Ministry of Health of Russia, Moscow, Russia

Lyundup A.V.

Center for Regenerative Medicine, Research Institute of Molecular Medicine, I.M. Sechenov First Moscow State Medical University, Moscow, Russia

Kiseleva E.V.

Russian Medical Academy of Continuous Professional Education, Moscow, Russia

ORCID: 0000-0001-5544-9655

Gorbacheva L.R.

Lomonosov Moscow State University, Moscow, Russia

Breslavich I.D.

Sechenov First Moscow State Medical University, Moscow, Russia

Kucenko K.I.

Bureau of Forensic Medicine of Moscow Healthcare Department, Moscow, Russia

Balyasin M.V.

Sechenov First Moscow State Medical University, Moscow, Russia

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