Clinical experience of using zonisamide in structural focal epilepsy in children with cerebral palsy

Badalian O.L.; Trepilets V.M.; Trepilets S.V.

doi:https://doi.org/10.17116/jnevro201811810290

Badalian O.L.

Kafedra nevrologii i neĭrokhirurgii lechebnogo fakul'teta

Trepilets V.M.

Morozovskaia detskaia gorodskaia klinicheskaia bol'nitsa Departamenta zdravookhraneniia Moskvy

Trepilets S.V.

Morozovskaia detskaia gorodskaia klinicheskaia bol'nitsa Departamenta zdravookhraneniia Moskvy

Clinical experience of using zonisamide in structural focal epilepsy in children with cerebral palsy

Authors:

Badalian O.L., Trepilets V.M., Trepilets S.V.

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Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2018;118(10‑2): 90‑97

DOI: 10.17116/jnevro201811810290

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To cite this article:

Badalian OL, Trepilets VM, Trepilets SV. Clinical experience of using zonisamide in structural focal epilepsy in children with cerebral palsy. S.S. Korsakov Journal of Neurology and Psychiatry. 2018;118(10‑2):90‑97. (In Russ.)
https://doi.org/10.17116/jnevro201811810290

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова. Спецвыпуски (S.S. Korsakov Journal of Neurology and Psychiatry (special issues))

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Abstract:

Objective. To evaluate the efficacy and safety of zonisamide as an add-on therapy in structural focal epilepsy in children with cerebral palsy (CP). Material and methods. Sixty-four patients (36 boys and 28 girls) with spastic CP and structural focal epilepsy with refractory seizures were followed up. Patients received zonisamide in a dose of 6—8.8 mg/kg/day for ≥6 months. Treatment efficacy was assessed by the reduction of seizures depending on CP form, type of epileptic seizures, combination of zonisamide with other drugs and adverse-effects. Results and conclusion. A reduction of seizures by ≥50% was identified in 60.9% of children, 10.9% showed a better recovery. The best efficacy (35.9%) was demonstrated in the treatment of generalized seizures with focal onset and in the combination with levetiracetam (35.9%). Adverse effects of mild to moderate severity were noted in 26.5% of children. The treatment was discontinued in 7.8%. Therefore, zonisamide is an effective treatment for refractory structural focal epilepsy in children with CP and comorbid pathology, which reduces the frequency of seizures without severe side-effects.

Keywords:

focal epilepsy

zonisamide

children

cerebral palsy

Authors:

Badalian O.L.

Kafedra nevrologii i neĭrokhirurgii lechebnogo fakul'teta

Trepilets V.M.

Morozovskaia detskaia gorodskaia klinicheskaia bol'nitsa Departamenta zdravookhraneniia Moskvy

Trepilets S.V.

Morozovskaia detskaia gorodskaia klinicheskaia bol'nitsa Departamenta zdravookhraneniia Moskvy

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References:

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