Complex assessment of the contribution of genetic factors to the risk of ischemic stroke

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Objective. To develop a method of the complex assessment of genetic risk for ischemic stroke (IS) and evaluate its effectiveness. Material and methods. Genotyping of 182 patients with atherothrombotic and cardioembolic subtypes of IS and 360 healthy individuals of 48 single nucleotide polymorphic loci (SNP) associated with the risk of II and its subtypes was performed. Results and conclusion. In each group of SNPs, composite indicators of genetic risk of IS in groups of patients and healthy controls were identified. Differences between the calculated values of the genetic risk in these groups were significant (p <0,05). The quality of the binary classification validated by ROC-analysis confirmed the predictive potential of the proposed method of risk calculation for determining the genetic predisposition to the development of IS.

Keywords:

ischemic stroke

genetic factors

genetic susceptibility

genetic risk assessment

Authors:

Korchagin V.I.

Central Research Institute of Epidemiology, Moscow, Russia

Mironov K.O.

FBUN «Tsentral'nyj NII epidemiologii» Rospotrebnadzora, Moskva

Platonov A.E.

Central Research Institute of Epidemiology, Moscow, Russia

Dribnokhodova O.P.

Central Research Institute of Epidemiology, Moscow, Russia

Akselrod E.V.

Central Research Institute of Epidemiology, Moscow, Russia

Dunaeva E.A.

FBUN «Tsentral'nyj NII epidemiologii» Rospotrebnadzora, Moskva

Raskurazhev A.A.

Neurology Research Center, Moscow, Russia

Tanashyan M.M.

Neurology Research Center, Moscow, Russia

Maksimova M.Yu.

Federal State budgetary scientific Institution «Research Centre of Neurology», Moscow

Illarioshkin S.N.

Nauchnyĭ tsentr nevrologii RAMN

Shipulin G.A.

Federal State Budgetary Institution of Science Central Research Institute of Epidemiology, Russian Federal Consumer Rights Protection and Human Health Control Service, Moscow

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