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Kozhieva M.Kh.

Pirogov Russian National Research Medical University, Moscow, Russia

Mel'nikov M.V.

Kafedra obshcheĭ khirurgii Sankt-Peterburgskoĭ gosudarstvennoĭ meditsinskoĭ akademii im. I.I. Mechnikova

Rogovsky V.S.

Pirogov Russian National Research Medical University, Moscow, Russia

Oleskin A.V.

Moscow State University, Moscow, Russia

Kabilov M.R.

Moscow State University, Moscow, Russia

Boĭko A.N.

KGBUZ "Krasnoiarskiĭ kraevoĭ Tsentr po profilaktike i bor'be so SPID i infektsionnymi zabolevaniiami"

Gut human microbiota and multiple sclerosis

Authors:

Kozhieva M.Kh., Mel'nikov M.V., Rogovsky V.S., Oleskin A.V., Kabilov M.R., Boĭko A.N.

More about the authors

Read: 6074 times


To cite this article:

Kozhieva MKh, Mel'nikov MV, Rogovsky VS, Oleskin AV, Kabilov MR, Boĭko AN. Gut human microbiota and multiple sclerosis. S.S. Korsakov Journal of Neurology and Psychiatry. 2017;117(10‑2):11‑19. (In Russ.)
https://doi.org/10.17116/jnevro201711710211-19

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References:

  1. Stys PK, Zampani GW, van Minnen J, Geurts JJ. G. Will the real multiple sclerosis please stand up? Nat Rev Neurosci. 2012;13:7:507-514.
  2. Melnikov MV, Paschenkov MV, Boyko AN Psychoneuroimmunology and multiple sclerosis. Journal of Neurology and Psychiatry im. S.S. Korsakov. 2015;115:2-2:8-15. (In Russ.)
  3. Ramagopalan SV, Dobson R, Meier UC, Giovannoni G. Multiple sclerosis: risk factors, prodromes, and potential causal pathways. Lancet Neurol. 2010;9:727-739.
  4. Huynh JL, Casaccia P. Epigenetic mechanisms in multiple sclerosis: implications for pathogenesis and treatment. Lancet Neurol. 2013;12:195-206.
  5. Fernandes O, Alvarez-Cermeno JC, Arnal-Garcia C, Arroyo-Gonzalez R, Brieva L, Callas-Hernandes MC, et al. Revision de las novedades presentadas en el XXIX Congreso del Comite Europeo para el Tratamiento e Investigacion en Esclerosis Multiple (ECTRIMS) (I). Rev Neurol. 2014;59:269-280.
  6. Arruti M, Castillo-Trivino T, Egues N, Olascoaga J. Tabaco y sclerosis multiple. Rev Neurol. 2015;60:169-178.
  7. Ascherio A, Munger KL, Simon KC. Vitamin D and multiple sclerosis. Lancet Neurol. 2010;9:599-612.
  8. Fragoso YD. Modifiable environmental factors in multiple sclerosis. Arq Neuropsiquiatr. 2014;72:889-894.
  9. Hedstrom AK, Hillert J, Olsson T, Alfredsson L. Alcohol as a modifiable lifestyle factor affecting multiple sclerosis risk. JAMA Neurol. 2014;71:300-305.
  10. Blasco-Quilez MR, Sanchez-Lopez AJ, Bermejo-Velasco PE, Carcia-Merino A. Esclerosis multiple. Factores etiolologicos, modelos experimentales, mecanismos patogenicos e inmunopatologia. Medicin. 2011;10:5069-5078.
  11. Gryan JF, Dinan TJ. Mind-altering microorganisms: the impact o the gut microbiota on brain and behavior. Nature Rev Neuroscience. 2012. https://doi.org/10.1038/nrn3346
  12. Lozupone CA. Stombaugh JI, Gordon JI, Jansson JK, Knight R. Diversity, stability and resilience of the human gut microbiota. Nature. 2012;489:220-230.
  13. Weinstock GM. Genomic approaches to studing the human microbiota. Nature. 2012;489:250-256.
  14. Goodrich JK, Davenport ER, Clark AG, Ley RE.The Relationship Between the Human Genome and Microbiome Comes into View. Annu Rev Genet. 2017. https://doi.org/10.1146/annurev-genet-110711-155532
  15. Botina SG, Koroban NV, Klimina KM, Glazova AA, Zinchenko VV, Danilenko VN. Genetic diversity of bacteria of the genus Lactobacillus from gastrointestinal microbioma of humans. Genetics. 2010;46(12):1589-1597. (In Russ.)
  16. Elson CO, Alexander KL. Host-microbiota interactions in the intesons in intestine. Dig Dis. 2015;33(2):131-136.
  17. Falana K, Knight R, Martin CR, Goldszmid R, Greathouse KL, Gere J, Young H, Kuo WP. Short Course in the Microbiome. J Circ Biomark. 2015;4:8. eCollection 2015 Jan-Dec. https://doi.org/10.5772/61257
  18. Dave M, Higgins PD, Middha S, Rioux KP. The human gut microbiome: current knowledge, challenges, and future directions. Transl Res J Lab Clin Med. 2012;160:246-257.
  19. Foster JA. Gut feelings: bacteria the brain. Cerebrum. 2013;9. PMCID: PMC3788166.
  20. Heitz RD, Wang S, Anuar F.Qian Y, Bjorkholm B, Samuelsson A, Hibberd ML, Forssberg H, Pettersson S. Normal gut microbiomamodulates brain development and behavior. Proc Nati Acad Sci USA. 2011;108(7):3047-3052.
  21. Bondarenko VM, Ryabichenko EV. The intestinal-cerebral axis. Neurogenic and immunoinflammatory mechanisms of the pathology of the brain and intestine. Microbiol. 2013;2:112-120. (In Russ.)
  22. Foster JA, Lyte M, Meyer E, Cryan JF. Gut Microbiota and Brain Function: An Evolving Field in Neuroscience. Int J Neuropsychopharmacol. 2016;19(5):114. Published online 2015 Oct 4. https://doi.org/10.1093/ijnp/pyv114
  23. Jiang H, Ling Z, Zhang Y, Mao H, Ma Z, Yin Y, Wang W, Tang W, Tan Z, Shi J, et al. Altered fecal microbiota composition in patients with major depressive disorder. Brain Behav Immun. 2015;48:186-194.
  24. Dinan TG, Cryan JF. Melancholic microbes: a link between gut microbiota and depression? Neurogastroenterol Motil. 2013;25:713-719.
  25. Manderino L, Carroll I, Azcarate-Peril MA, Rochette A, Heinberg L, Peat C, Steffen K, Mitchell J, Gunstad J. Preliminary Evidence for an Association Between the Composition of the Gut Microbiome and Cognitive Function in Neurologically Healthy Older Adults. J Int Neuropsychol Soc. 2017;23(8): 700-705. Epub 2017 Jun 23. https://doi.org/10.1017/S1355617717000492
  26. Carlson AL, Xia K, Azcarate-Peril MA, Goldman BD, Ahn M, Styner MA, Thompson AL, Geng X, Gilmore JH, Knickmeyer RC. Infant Gut Microbiome Associated With Cognitive Development. Biol Psychiatry. 2017;0006-3223(17)31720-1. https://doi.org/10.1016/j.biopsych.2017.06.021
  27. Gareau MG. Cognitive Function and the Microbiome. Int Rev Neurobiol. 2016;131:227-246. Epub 2016 Sep 9. https://doi.org/10.1016/bs.irn.2016.08.001
  28. Bercik P, Denou E, Collins J, Jackson W, Lu J, Jury J, Deng Y, Blennerhassett P, Macri J, McCoy KD, Verdu EF, Collins SM. The intestinal microbiota affect central levels of brain-derived neurotropic factor and behavior in mice. Gastroenterology. 2011;141(2):599-609, 609.e1-3. Epub 2011 Apr 30. https://doi.org/10.1053/j.gastro.2011.04.052
  29. Krisztian Bene, Zsofia Varga, Viktor O. Petrov, Nadiya Boyko, and Eva Rajnavolgyi. Gut Microbiota Species Can Provoke both Inflammatory and Tolerogenic Immune Responses in Human Dendritic Cells Mediated by Retinoic Acid Receptor Alpha Ligation. Front Immunol. 2017;8:427. Published online 2017 Apr 18. https://doi.org/10.3389/fimmu.2017.00427
  30. Steimle A, Frick J-S. Molecular Mechanisms of Induction of Tolerant and Tolerogenic Intestinal Dendritic Cells in Mice. J Immunol Res. 2016;1958650. Published online 2016 Feb 11. https://doi.org/10.1155/2016/1958650
  31. Sun CM, Hall JA, Blank RB, Bouladoux N, Oukka M, Mora JR, Belkaid Y. Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acid. J Exp Med. 2007;204(8):1775-1785. Epub 2007 Jul 9.
  32. Atarashi K, Tanoue T, Shima T, Imaoka A, Kuwahara T, Momose Y, Cheng G, Yamasaki S, Saito T, Ohba Y, Taniguchi T, Takeda K, Hori S, Ivanov II, Umesaki Y, Itoh K, Honda K. Induction of colonic regulatory T cells by indigenous Clostridium species. Science. 2011;331(6015):337-341. Epub 2010 Dec 23. https://doi.org/10.1126/science.1198469
  33. Geuking MB, Cahenzli J, Lawson MA, Ng DC, Slack E, Hapfelmeier S, McCoy KD, Macpherson AJ. Intestinal bacterial colonization induces mutualistic regulatory T cell responses. Immunity. 2011;34(5):794-806. Epub 2011 May 19. https://doi.org/10.1016/j.immuni.2011.03.021
  34. Di Giacinto C, Marinaro M, Sanchez M, Strober W, Boirivant M. Probiotics ameliorate recurrent Th1-mediated murine colitis by inducing IL-10 and IL-10-dependent TGF-beta-bearing regulatory cells. J Immunol. 2005;174(6):3237-3246.
  35. Ivanov II, Frutos Rde L, Manel N, Yoshinaga K, Rifkin DB, Sartor RB, Finlay BB, Littman DR.Specific microbiota direct the differentiation of IL-17-producing T-helper cells in the mucosa of the small intestine. Cell Host Microbe. 2008;4(4):337-349. https://doi.org/10.1016/j.chom.2008.09.009
  36. Mazmanian SK, Liu CH, Tzianabos AO, Kasper DL. An immunomodulatory molecule of symbiotic bacteria directs maturation of the host immune system. Cell. 2005;122(1):107-118.
  37. Bettelli E, Oukka M, Kuchroo VK. T(H)-17 cells in the circle of immunity and autoimmunity. Nat Immunol. 2007;8(4):345-350.
  38. Kim M, Kim CH. Regulation of humoral immunity by gut microbial products. Gut Microbes. 2017;8(4):392-399. Epub 2017 Feb 28. https://doi.org/10.1080/19490976.2017.1299311
  39. Yasmine Belkaid and Timothy Hand. Role of the Microbiota in Immunity and inflammation Cell. 2014;157(1):121-141. https://doi.org/10.1016/j.cell.2014.03.011
  40. Zhong D, Wu C, Zeng X, Wang Q. The role of gut microbiota in the pathogenesis of rheumatic diseases. Clin Rheumatol. 2017. https://doi.org/10.1007/s10067-017-3821-4
  41. Oleskin AV, Shenderov BA, Rogovsky VS. Role of Neurochemicals in the Interaction between the Microbiota and the Immune and the Nervous System of the Host Organism. Probiotics Antimicrob Proteins. 2017:1-20. https://doi.org/10.1007/s12602-017-9262-1
  42. Boyko A, Melnikov M, Ghetishev R, Pashenkov M. The role of biogenic amines in regulation of interaction between immune and nervous systems in multiple sclerosis. Neuroimmunomodulation. 2016;23(4):217-223. https://doi.org/10.1159/000449167
  43. Melnikov MV, Belousova OO, Murugin VV, Pashenkov MV, Boyko AN. The role of dopamine in modulation of Th-17 immune response in multiple sclerosis. Journal of Neuroimmunology. 2016;292:97-101.
  44. Gershon MD, Tack J. The serotonin signaling system: from basic understanding to drug development for functional GI disorders. Gastroenterology. 207;132:397-414.
  45. Mawe GM, Hoffman JM. Serotonin signalling in the gut — functions, dysfunctions and therapeutic targets. Nat Rev Gastroenterol Hepatol. 2013;10:473-486.
  46. Reigstad CS, Salmonson CE, Rainey JF 3rd, Szurszewski JH, Linden DR, Sonnenburg JL, Farrugia G, Kashyap PC. Gut microbes promote colonic serotonin production through an effect of short-chain fatty acids on enterochromaffin cells. FASEB J. 2015;29(4):1395-1403. https://doi.org/10.1096/fj.14-259598
  47. Asano Y, Hiramoto T, Nishino R, Aiba Y, Kimura T, Yoshihara K, Koga Y, Sudo N. Critical role of gut microbiota inthe production of biologically active, free catecholamine in the gut lumen of mice. Am J Physiol Gastrointest Liver Physiol. 2012;303(11):1288-1295. Epub 2012 Oct 11. https://doi.org/10.1152/ajpgi.00341.2012
  48. Mittal R, Debs LH, Patel AP, Nguyen D, Patel K, O’Connor G, Grati M, Mittal J, Yan D, Eshraghi AA, Deo SK, Daunert S, Liu XZ. Neurotransmitters: The Critical Modulators Regulating Gut-Brain Axis. J Cell Physiol. 2017;232(9):2359-2372. Epub 2017 Apr 10. https://doi.org/10.1002/jcp.25518
  49. Patterson E, Cryan JF, Fitzgerald GF, Ross RP, Dinan TG, Stanton C. Gut microbiota, the pharmabiotics they produce and host health. Proc Nutr Soc. 2014;73(4):477-489. Epub 2014 Sep 8. https://doi.org/10.1017/S0029665114001426
  50. Dinan TG, Stanton C, Cryan JF. Psychobiotics: a novel class of psychotropic. Biol Psychiatry. 2013;74:720-726.
  51. Yano JM, Yu K, Donaldson GP, Shastri GG, Ann P, Ma L, Nagler CR, Ismagilov RF, Mazmanian SK, Hsiao EY. Indigenous Bacteria from the Gut Microbiota Regulate Host Serotonin Biosynthesis. Cell. 2015;161(2):264-276. https://doi.org/10.1016/j.cell.2015.02.047
  52. Oleskin AV, Rogovsky VS. The role of biogenic amines in the interaction of the microbiota, nervous and immune systems of the host organism. Bulletin of Restorative Medicine. 2017;1:41-51. (In Russ.)
  53. Rook GAW, Raison CL, Lowry CA. Can we vaccinate against depression? Drug discovery today. 2012;17:9:451-458.
  54. Martins FS, Nardi RM, Arantes RM, Rosa CA, Neves MJ, Nicoli JR. Screening of yeasts as probiotic based on capacities to colonize the gastrointestinal tract and to protect against enteropathogen challenge in mice. The Journal of general and applied microbiology. 2005;51:2:83-92.
  55. O’Mahony SM, Clarke G, Borre YE, Dinan TG, Cryan JF. Serotonin, tryptophan metabolism and the brain-gut-microbiome axis. Behav Brain Res. 2015;277:32-48.
  56. Savignac HM, Couch Y, Stratford M, et al. Prebiotic administration normalizes lipopolysaccharide (LPS) induced anxiety and cortical 5-HT2A receptor and IL1-β levels in male mice. Brain Behav Immun. 2016;52:120-131. https://doi.org/10.1016/j.bbi.2015.10.007
  57. Clarke G, Grenham S, Scully P, Fitzgerald P, Moloney RD, Shanahan F, Dinan TG, Cryan JF. The microbiome-gut-brain axis during early life regulates the hippocampal serotonergic system in a sex-dependent manner. Mol Psychiatry. 2012;18(10):666-673. https://doi.org/10.1038/mp.2012.77
  58. Jenkins TA, Nguyen JC, Polglaze KE, Bertrand PP. Influence of Tryptophan and Serotonin on Mood and Cognition with a Possible Role of the Gut-Brain Axis. Nutrients. 2016;8(1):56. https://doi.org/10.3390/nu8010056
  59. Foster JA, Rinaman L, Cryan JF. Stress & the gut-brain axis: Regulation by the microbiome. Neurobiology of Stress. 2017.
  60. Ho P, Ross DA. More than a gut feeling: the implications of the gut microbiota in psychiatry. Biological psychiatry. 2017;81:5:35.
  61. Youdim MBH, Bakhle YS. Monoamine oxidase: isoforms and inhibitors in Parkinson’s disease and depressive illness. British journal of pharmacology. 2006;147:1.
  62. Bellono NW, Bayrer JR, Leitch DB, Castro J, Zhang C, O’Donnell TA, Brierley SM, Ingraham HA, Julius D. Enterochromaffin cells are gut chemosensors that couple to sensory neural pathways. Cell. 2017;170:1:185-198. e16.
  63. Shen Q, Shang N, Li P. In vitro and in vivo antioxidant activity of Bifidobacterium animalis 01 isolated from centenarians. Current microbiology. 2011;62:4:1097-1103.
  64. Kirpichenko AA, Kim IYu. Psychobiotics: is the intestinal microbiota capable of influencing the mental health of the host? Bulletin of Vitebsk State Medical University. 2017;16:2. (In Russ.)
  65. Oleskin AV, El-Registan GI, Shenderov BA. Inter-microbial chemical interactions and microbiota-host dialogue: the role of neurotransmitters. Microbiology. 2016;85(1):1-24. (In Russ.)
  66. Lyte M. Microbial endocrinology in the pathogenesis of infectious disease. Microbiol Spectrum. 2016;4(2):VMBF-0021-2015. https://doi.org/10.1128/microbiolspec.VMBF-0021-2015
  67. Tsavkelova EA, Botvinko IB, Kudrin VS, Oleskin AB. Detection of neurotransmitter amines in microorganisms by high-performance liquid chromatography. Docle Ross Acad Sciences. 2000;372:840-842. (In Russ.)
  68. Oleskin AV, Zhilenkova OG, Shenderov BA, Amerkhanova AM, Kudrin VS, Klodt PM. Starter cultures of lactobacilli are producers of neurotransmitters: biogenic amines and amino acids. Dairy industry. 2014;9:42-43. (In Russ.)
  69. Clark MB Hughes DT, Zhu C, Boedeker EC, & Sperandio V. The QseC sensor kinase: A bacterial adrenergic receptor. Proc Natl Acad Sci USA. 206;103:10420-10425.
  70. Freestone PP, Haigh RD, Lyte M. Blockade of catecholamine-induced growth by adrenergic and dopaminergic receptor agonists in Escherichia coli O157:H7, Salmonella enteric, and Yersinia enterocolitica. BMC Microbiol. 2007;7:8.
  71. Anuchin AM, Chuvelev DI, Kirovskaya TA, Oleskin AV The effect of neurotransmitter monoamines on the growth characteristics of Escherichia coli K-12. Microbiology. 2008;77:674-680. (In Russ.)
  72. Shishov VA, Kirovskaya TA, Kudrin VS, & Oleskin AV. Amine neuromediators, their precursors, and oxidation products in the culture of Escherichia coli K-12. Appl Biochem Mikrobiol. 2009;45:494-497.
  73. Burton CL, Chhabra SR, Swift S, Baldwin TJ, Withers H, Hill SJ, & Williams P. The growth response of Escherichia coli to neurotransmitters and related catecholamine drugs requires a functional enterobactin biosynthesis and uptake system. Infect Immunol. 2002;70:5913-5923.
  74. Moreira CG, Russell R, Mishra AA, Narayanan S, Ritchie JM, Waldor MK, Curtis MM, Winter SE, Weinshenker D, Sperandio V Bacterial adrenergic sensors regulate virulence of enteric pathogens in the gut. MBio. 2016;7:3:00826-16.
  75. Rogovskii VS. The linkage between inflammation and immune tolerance: interfering with inflammation in cancer. Current cancer drug targets. 2017;17:4:325-332.
  76. Nouri M, Bredberg A, Weström B, Lavasani S. Intestinal barrier dysfunction develops at the onset of experimental autoimmune encephalomyelitis, and can be induced by adoptive transfer of auto-reactive T cells. PLoS One. 2014;9(9):106335. eCollection 2014. https://doi.org/10.1371/journal.pone.0106335
  77. Stanisavljević S, Lukić J, Momčilović M, Miljković M, Jevtić B, Kojić M, Golić N, Mostarica Stojković M, Miljković D. Gut-associated lymphoid tissue, gut microbes and susceptibility to experimental autoimmune encephalomyelitis. Benef Microbes. 2016;7(3):363-373. Epub 2016 Feb 3. https://doi.org/10.3920/BM2015.0159
  78. Stanisavljević S, Lukić J, Soković S, Mihajlovic S, Mostarica Stojković M, Miljković D, Golić N. Correlation of Gut Microbiota Composition with Resistance to Experimental Autoimmune Encephalomyelitis in Rats. Front Microbiol. 2016;7:2005. eCollection 2016. https://doi.org/10.3389/fmicb.2016.02005
  79. Lee YK, Menezes JS, Umesaki Y, Mazmanian SK. Proinflammatory T-cell responses to gut microbiota promote experimental autoimmune encephalomyelitis. Proc Natl Acad Sci USA. 2011;108(suppl 1):4615-4622. Epub 2010 Jul 26. https://doi.org/10.1073/pnas.1000082107
  80. Abdurasulova IN Tarasova E., Matsulevich AV, Eliseev AV, Ermolenko EI, Suvorov AN, Klimenko V.М. Change in qualitative and quantitative composition of intestinal microbiota in rats during experimental allergic encephalomyelitis. Russian Physiological Journal. 2015;11:1235-1249. (In Russ.)
  81. Ezendam J, de Klerk A, Gremmer ER. van Loveren H. Effects of Bifidobacterium animals administered during lactation on allergic and autoimmune responses in rodents. Clin Exp Immunol. 2008;154:3:1714-1723.
  82. Kwon HK, Kim GC, Kim Y, Hwang W, Jash A, Sahoo A, Kim JE, Nam JH, Im SH. Amelioration of experimental autoimmune encephalomyelitis by probiotic mixture is mediated by a shift in T helper cell immune response. Clin Immunol. 2013;146:3:217-227.
  83. Baken KA, Ezendam J, Gremmer ER, de Klerk A, Pennings JL, Matthee B, Peijnenburg AA, van Loveren H. Evaluation of immunomodulation by Lactobacillus casei Shirota: immune function, autoimmunity and gene expression. Int J Food Microbiol. 2006;112:1:8-18.
  84. Maassen CB, Claassen E. Strain-dependent effects of probiotic lactobacilli on EAE autoimmunity. Vaccine. 2008;26:17:2056-2057.
  85. Ochoa-Repáraz J, Mielcarz DW, Ditrio LE, Burroughs AR, Foureau DM, Haque-Begum S, Kasper LH. Role of Gut Commensal Microflora in the Development of Experimental Autoimmune Encephalomyelitis. J Immunol. 2009;83(10):6041-6050. https://doi.org/10.4049/jimmunol.0900747
  86. Ochoa-Reparaz J, Mielcarz DW, Haque-Begum S, Kasper LH. Induction of a regulatory B cell population in experimental allergic encephalomyelitis by alteration of the gut commensal microflora. Gut Microbes. 2010;1(2):103-108. Epub 2010 Feb 15.
  87. Colpitts SL, Kasper EJ, Keever A, Liljenberg C, Kirby T, Magori K, Kasper LH, Ochoa-Repáraz J. A bidirectional association between the gut microbiota and CNS disease in a biphasic murine model of multiple sclerosis. Gut Microbes. 2017:1-13. https://doi.org/10.1080/19490976.2017.1353843
  88. Willer CJ, Dyment DA, Risch NJ, Sadovnick AD, Ebers GC; Canadian Collaborative Study Group. Twin concordance and sibling recurrence rates in multiple sclerosis. Proc Natl Acad Sci USA. 2003;100(22):12877-12882. Epub 2003 Oct 20.
  89. Fleck AK, Schuppan D, Wiendl H, Klotz L. Gut-CNS-Axis as Possibility to Modulate Inflammatory Disease Activity-Implications for Multiple Sclerosis. Int J Mol Sci. 2017;18(7):1526. https://doi.org/10.3390/ijms18071526
  90. Jun Chen, Nicholas Chia, Krishna R. Kalari, Janet Z. Yao, Martina Novotna, M. Mateo Paz Soldan, David H. Luckey, Eric V. Marietta, Patricio R. Jeraldo, Xianfeng Chen, Brian G. Weinshenker, Moses Rodriguez, Orhun H. Kantarci, Heidi Nelson, Joseph A. Murray and Ashutosh K. Mangalam. Multiple sclerosis patients have a distinct gut microbiota compared to healthy controls. Sci Rep. 2016;6:28484. Published online 2016 Jun 27. https://doi.org/10.1038/srep28484
  91. Sachiko M, Sangwan K, Wataru S, Kenshiro O, Masakazu N, Takako M, Norio Ch, Atsuko T, Wakiro S, Seok-Won K, Hidetoshi M, Masahira H, Takashi Y. Dysbiosis in the Gut Microbiota of Patients with Multiple Sclerosis, with a Striking Depletion of Species Belonging to Clostridia XIVa and IV Clusters. PLoS One. 2015;10(9):0137429. Published online 2015 Sep 14. https://doi.org/10.1371/journal.pone.0137429
  92. Cekanaviciute E, Yoo BB, Runia TF, Debelius JW, Singh S, Nelson CA, Kanner R, Bencosme Y, Lee YK, Hauser SL, Crabtree-Hartman E, Katz Sand I, Gacias M, Zhu Y, Casaccia P, Cree BAC, Knight R, Mazmanian SK, Baranzini SE. Gut bacteria from multiple sclerosis patients modulate human T cells and exacerbate symptoms in mouse models. Proc Natl Acad Sci USA. 2017;201711235. https://doi.org/10.1073/pnas.1711235114
  93. Berer K, Gerdes LA, Cekanaviciute E, Jia X, Xiao L, Xia Z, Liu C, Klotz L, Stauffer U, Baranzini SE, Kümpfel T, Hohlfeld R, Krishnamoorthy G, Wekerle H. Gut microbiota from multiple sclerosis patients enables spontaneous autoimmune encephalomyelitis in mice. Proc Natl Acad Sci USA. 2017;201711233. https://doi.org/10.1073/pnas.1711233114
  94. Cantarel BL, Waubant E, Chehoud C, Kuczynski J, DeSantis TZ, Warrington J, Venkatesan A, Fraser CM, Mowry EM.Gut microbiota in multiple sclerosis: possible influence of immunomodulators. J Investig Med. 2015;63(5):729-734. https://doi.org/10.1097/JIM.0000000000000192
  95. Rumah KR, Vartanian TK, Fischetti VA.Oral Multiple Sclerosis Drugs Inhibit the In vitro Growth of Epsilon Toxin Producing Gut Bacterium, Clostridium perfringens. Front Cell Infect Microbiol. 2017;7:11. eCollection 2017. https://doi.org/10.3389/fcimb.2017.00011

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