Hormonal treatment in West syndrome

Belousova E.D.; Shulyakova I.V.; Ohapkina T.G.

doi:https://doi.org/10.17116/jnevro20161169261-66

Belousova E.D.

Moskovskiĭ NII pediatrii i detskoĭ khirurgii

SPIN RSCI: 6594-3049
Scopus AuthorID: 24767524000
ORCID: 0000-0003-3594-6974

Shulyakova I.V.

Veltischev Research and Clincal Institute of Pediatric, Moscow, Russia, Pirogov Russian National Research Medical University, Moscow, Russia

Ohapkina T.G.

Veltischev Research and Clincal Institute of Pediatric, Moscow, Russia, Pirogov Russian National Research Medical University, Moscow, Russia

Hormonal treatment in West syndrome

Authors:

Belousova E.D., Shulyakova I.V., Ohapkina T.G.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2016;116(9‑2): 61‑66

DOI: 10.17116/jnevro20161169261-66

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To cite this article:

Belousova ED, Shulyakova IV, Ohapkina TG. Hormonal treatment in West syndrome. S.S. Korsakov Journal of Neurology and Psychiatry. 2016;116(9‑2):61‑66. (In Russ.)
https://doi.org/10.17116/jnevro20161169261-66

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова. Спецвыпуски (S.S. Korsakov Journal of Neurology and Psychiatry (special issues))

Использование инфографики авторами научных работ

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Abstract:

West syndrome is one of the most well-known epileptic encephalopathies, a catastrophic epilepsy syndrome with onset in the first year of life. Prognosis of this condition depends on the etiology and adequate treatment. The authors review the hormonal treatment of West syndrome. Adrenocorticotrophic hormone (ACTH) is used in USA and its synthetic analogue tetracosactide is used in Europe. Both of the drugs are not registered in the Russian Federation. The data on the efficacy of corticosteroids, including prednisolone, are contradictory. Recent results have demonstrated the high efficacy of prednisolone in the treatment of West syndrome. The authors discuss different aspects of hormonal treatment of West syndrome: possible mechanisms, choice of medication, hormone doses, its duration, efficacy ant tolerability.

Keywords:

West syndrome

infantile spasms

adrenocorticotrophic hormone (ACTH)

tetracosactide

prednisolone

dexamethasone

hydrocortisone

efficacy

tolerability

Authors:

Belousova E.D.

Moskovskiĭ NII pediatrii i detskoĭ khirurgii

SPIN RSCI: 6594-3049
Scopus AuthorID: 24767524000
ORCID: 0000-0003-3594-6974

Shulyakova I.V.

Veltischev Research and Clincal Institute of Pediatric, Moscow, Russia, Pirogov Russian National Research Medical University, Moscow, Russia

Ohapkina T.G.

Veltischev Research and Clincal Institute of Pediatric, Moscow, Russia, Pirogov Russian National Research Medical University, Moscow, Russia

Close metadata

References:

Go CY et al, Evidence-based guideline update: medical treatment of infantile spasms. Report of the Guideline Development Subcommittee of the American Academy of Neurology and the Practice Committee of the Child Neurology Society. Neurology. 2012;12:78(24):1974-1980.
Taghdiri MM, Nemati H. Infantile Spasm: A Review Article. Iran J Child Neurol. 2014;8(3):1-5.
Pellock JM, Hrachovy R, Shinnar S et al. Infantile spasms: a U.S. consensus report. Epilepsia. 2010;51(10);2175-2189.
Wheless JW, Clarke DF, Arzimanoglou A, Carpenter D. Treatment of pediatric epilepsy: European expert opinion, Epileptic Disord. 2007;9(4):353-412.
Wilmshurst JM, Gaillard WD, Vinayan KP et al. Summary of recommendations for the management of infantile seizures: Task Force Report for the ILAE Commission of Pediatrics. Epilepsia. 2015;56(8):1185-1197.
Riikonen R. Recent advances in the pharmacotherapy of infantile spasms. 2014;28(4):279-290.
Lux A, Edwards S, Hancock E et al. The United Kingdom infantile spasm study comparing vigabatrin with prednisolone or tetracosactide at 14 days: a multicentre, randomized controlled trial. Lancet. 2004;364:1773-1778.
Granata T, Cross H, Theodore W, Avanzini G. Immune-mediated epilepsies. Epilepsia. 2011;52(suppl 3):5-11.
Auvin S, Hartman AL, Desnous B, Moreau AC et al. Diagnosis delay in West syndrome: misdiagnosis and consequences. Eur J Pediatr. 2012;171(11):1695-1701.
Shumiloff NA, Lam WM, Manasco KB. Adrenocorticotropic hormone for the treatment of West Syndrome in children. Ann Pharmacother. 2013;47(5):744-754.
Klinicheskie rekomendacii po diagnostike i lecheniju jepilepsii. V kn.: Detskaja nevrologija. Klinicheskie rekomendacii. Vypusk 1. Pod red. Guzevoj V.I. M.: OOO «MK»; 2014.
Mytinger JR, Quigg M, Taft W et al. Outcomes in treatment of infantile spasms with pulse methylprednisolone. J Child Neurol. 2010;25:948-953.
Volkov I.V., Volkova O.K. Vozrastnaja transformacija infantil'nyh spazmov v farmakorezistentnuju jepilepsiju. Zhurnal nevrologii i psihiatrii im. S.S. Korsakova. 2012;112:12:19-25.
Haberlandt E, Weger C, Baumgartner Sigl S et al. Adrenocorticotropic hormone versus pulsatile dexamethasone in the treatment of infantile epilepsy syndromes. Pediatr Neurol. 2010;42:21-27.
Muhin K.Ju., Petruhin A.S. Jepilepticheskie sindromy. Diagnsotika i standarty terapii. Spravochnoe rukovodstvo. M. 2005.
Pavone P, Striano P, Falsaperla R et al. Infantile spasms syndrome, West syndrome and related phenotypes: What we know in 2013. Brain & Development. 2014;36(9):739-751.
Wanigasinghe J, Arambepola C, Ranganathan SS et al. Randomized, Single-Blind, Parallel Clinical Trial on Efficacy of Oral Prednisolone Versus Intramuscular Corticotropin on Immediate and Continued Spasm Control in West Syndrome. Pediatric Neurology. 2015;53:193-199.
Knupp KG, Coryell J, Nickels KC et al. Response To Treatment In A Prospective National Infantile Spasms Cohort. Ann Neurol. 2015. doi: 10.1002/ana.24594
Farnosova ME, Zharikova TF, Gamirova RG, Sivkova SN. Timing of treatment initiation in West's syndrome. J Risk Saf Med. 2015;27(suppl 1):55-56.
Ikegami M, Takahashi Y, Ikeda H, Imai K, Otani H, Kubota Y, Shigematsu H, Takayama R, Mogami Y. Efficacy of repeated adrenocorticotropic hormone therapy in patients with intractable epileptic spasms. No To Hattatsu. 2013;45(4):281-287.
Mytinger JR, Bowden SA. Adrenal Function Testing Following Hormone Therapy for Infantile Spasms: Case Series and Review of Literature. Front Neurol. 2015;8:6:259.
Dulac O, Plecko B, Gataullina S, Wolf NI. Occasional seizures, epilepsy, and inborn errors of metabolism. Lancet Neurol. 2014;13(7):727-739.