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Rider F.K.

Soloviev Moscow Research and Clinical for Neuropsychiatry, Moscow, Russia

Danilenko O.A.

Soloviev Research and Practical Psychoneurological Center, Moscow Department of Public Health, Moscow

Grishkina M.N.

Moscow Research and Clinical Center for Neuropsychiatry, Moscow

Kustov G.V.

Soloviev Moscow Research and Clinical for Neuropsychiatry, Moscow, Russia

Akzhigitov R.G.

Serbsky Federal Medical Research Centre for Psychiatry and Narcology;
Soloviev Scientific and Practical Center of Psychoneurology

Lebedeva A.V.

FGBU "Federal'nyĭ nauchnyĭ tsentr transplantologii i iskusstvennykh organov im. akad. V.I. Shumakova" Minzdrava Rossii, Moskva

Guekht A.B.

Moscow Research and Clinical Centre for Neuropsychiatry;
Pirogov Russian National Research Medical University

Depression and epilepsy: comorbidities, pathogenesis, principles of therapy

Authors:

Rider F.K., Danilenko O.A., Grishkina M.N., Kustov G.V., Akzhigitov R.G., Lebedeva A.V., Guekht A.B.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2016;116(9‑2): 19‑24

DOI: 10.17116/jnevro20161169219-24

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Table of contents

DEPRESSION AND EPILEPSY: COMORBIDITIES, PATHOGENESIS, PRINCIPLES OF THERAPY
DEPRESSION AND EPILEPSY: COMORBIDITIES, PATHOGENESIS, PRINCIPLES OF THERAPY

To cite this article:

Rider FK, Danilenko OA, Grishkina MN, Kustov GV, Akzhigitov RG, Lebedeva AV, Guekht AB. Depression and epilepsy: comorbidities, pathogenesis, principles of therapy. S.S. Korsakov Journal of Neurology and Psychiatry. 2016;116(9‑2):19‑24. (In Russ.)
https://doi.org/10.17116/jnevro20161169219-24

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова. Спецвыпуски (S.S. Korsakov Journal of Neurology and Psychiatry (special issues))
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Abstract:

Numerous trials of last years confirm the bilateral link between depression and epilepsy with mutual complication of both diseases. Depression increases the risk of the first unprovoked paroxysm, worsens the compliance of epileptic patients, leads to decrease of the response both to therapeutic and surgical treatment and to increase of side effects of antiepileptic drugs. Depression is associated with high risk of suicidal behavior and reduces the quality of life level. Depression in epileptic patients is characterized by atypical clinical course in most cases what makes its diagnostics difficult and becomes the reason of the absence of the necessary pharmacologic and psychotherapeutic treatment. All of the above creates significant economical burden for the community because the epileptic patient with comorbid depression visits the physicians 2—4 times more often.

Keywords:

epilepsy
depression
comorbidity
interictal dysphoric disorder
antidepressants

Authors:

Rider F.K.

Soloviev Moscow Research and Clinical for Neuropsychiatry, Moscow, Russia

Danilenko O.A.

Soloviev Research and Practical Psychoneurological Center, Moscow Department of Public Health, Moscow

Grishkina M.N.

Moscow Research and Clinical Center for Neuropsychiatry, Moscow

Kustov G.V.

Soloviev Moscow Research and Clinical for Neuropsychiatry, Moscow, Russia

Akzhigitov R.G.

Serbsky Federal Medical Research Centre for Psychiatry and Narcology;
Soloviev Scientific and Practical Center of Psychoneurology

Lebedeva A.V.

FGBU "Federal'nyĭ nauchnyĭ tsentr transplantologii i iskusstvennykh organov im. akad. V.I. Shumakova" Minzdrava Rossii, Moskva

Guekht A.B.

Moscow Research and Clinical Centre for Neuropsychiatry;
Pirogov Russian National Research Medical University

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