Prognostic biochemical markers of thrombolytic therapy in ischemic stroke

Kicherova O.A.; Reikhert L.I.; Skorikova V.G.; Semeshko S.A.

doi:https://doi.org/10.17116/jnevro20161168248-51

Kicherova O.A.

Permskaia gosudarstvennaia meditsinskaia akademiia im. akad. E.A. Vagnera

Reikhert L.I.

Tyumen State Medical Academy Ministry University, Tyumen, Russia

Skorikova V.G.

Tyumen State Medical Academy Ministry University, Tyumen, Russia

Semeshko S.A.

Tyumen State Medical Academy Ministry University, Tyumen, Russia

Prognostic biochemical markers of thrombolytic therapy in ischemic stroke

Authors:

Kicherova O.A., Reikhert L.I., Skorikova V.G., Semeshko S.A.

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Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2016;116(8‑2): 48‑51

DOI: 10.17116/jnevro20161168248-51

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To cite this article:

Kicherova OA, Reikhert LI, Skorikova VG, Semeshko SA. Prognostic biochemical markers of thrombolytic therapy in ischemic stroke. S.S. Korsakov Journal of Neurology and Psychiatry. 2016;116(8‑2):48‑51. (In Russ.)
https://doi.org/10.17116/jnevro20161168248-51

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова. Спецвыпуски (S.S. Korsakov Journal of Neurology and Psychiatry (special issues))

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Abstract:

Objective. To assess prognostic value of endothelial dysfunction, endogenous intoxication and oxidative stress in the acute period of ischemic stroke (II) at the stage of making a decision on using thrombolytic therapy (TLT) as well during the follow-up in order to personalize treatment. Material and methods. The study included 57 patients stratified into control group 1 (n=29) and TLT group (n=28). Contents of C-reactive protein (Nsrb), matrixmetalloproteinase-9 (MMP-9) erythrocyte lipid peroxidation products were measured in the blood of patients. Clinical outcomes were evaluated with the modified Rankin scale and the Rivermead Mobility Index. Results. Increased levels of Nsrb and MMP-9 were the biomarkers of poor TLT outcome. Conclusion. TLT has a positive effect on the basic patterns of IS pathogenesis and biochemical predictors allow to rationalize the treatment.

Keywords:

ischemic stroke

thrombolytic therapy

oxidative stress

endothelial dysfunction

endogenous intoxication

matrixmetalloproteinase

Authors:

Kicherova O.A.

Permskaia gosudarstvennaia meditsinskaia akademiia im. akad. E.A. Vagnera

Reikhert L.I.

Tyumen State Medical Academy Ministry University, Tyumen, Russia

Skorikova V.G.

Tyumen State Medical Academy Ministry University, Tyumen, Russia

Semeshko S.A.

Tyumen State Medical Academy Ministry University, Tyumen, Russia

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References:

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