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L.A. Belova

Ul'ianovskiĭ gosudarstvennyĭ universitet

V.V. Mashin

V.V. Abramova

A.N. Proshin

Ulyanovsk State University, Ulyanovsk

A.N. Ovsjannikova

Ulyanovsk State University, Ulyanovsk, Russia

Cognitive impairment in patients poluchennym ischemic stroke in the acute and early recovery periods in the process of neuroprotection low-dose drug cortexin

Authors:

L.A. Belova, V.V. Mashin, V.V. Abramova, A.N. Proshin, A.N. Ovsjannikova

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2016;116(8‑2): 40‑43

DOI: 10.17116/jnevro20161168240-43

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Table of contents

COGNITIVE IMPAIRMENT IN PATIENTS POLUCHENNYM ISCHEMIC STROKE IN THE ACUTE AND EARLY RECOVERY PERIODS IN THE PROCESS OF NEUROPROTECTION LOW-DOSE DRUG CORTEXIN
COGNITIVE IMPAIRMENT IN PATIENTS POLUCHENNYM ISCHEMIC STROKE IN THE ACUTE AND EARLY RECOVERY PERIODS IN THE PROCESS OF NEUROPROTECTION LOW-DOSE DRUG CORTEXIN

To cite this article:

Belova LA, Mashin VV, Abramova VV, Proshin AN, Ovsjannikova AN. Cognitive impairment in patients poluchennym ischemic stroke in the acute and early recovery periods in the process of neuroprotection low-dose drug cortexin. S.S. Korsakov Journal of Neurology and Psychiatry. 2016;116(8‑2):40‑43. (In Russ.)
https://doi.org/10.17116/jnevro20161168240-43

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова. Спецвыпуски (S.S. Korsakov Journal of Neurology and Psychiatry (special issues))
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Abstract:

The purpose of the study. To study the effect of repeated low-dose course of neuroprotection by drug cortexin on cognitive impairment in the acute and early recovery periods of hemispheric ischemic stroke. Material and methods. The study involved 90 patients with poluchennym ischemic stroke. Patients of the first group received cortexin 20 mg (10+10) intramuscularly on the background of basic therapy, patients of the second group (n=30) received cortexin 20 mg (10+10) two courses for 10 days each with a break in between of 10 days, the patients of the third group — only basic therapy. For the objectification of cognitive impairment used a scale MMSE, a test of 5 words, the battery of frontal dysfunction, clock drawing test, MOCA test. Results. It was noted more rapid and complete regression of cognitive disorders in patients of the 1st and 2nd groups, in comparison with patients of the 3rd group. However, the best effect of the therapy was observed still in the group of patients treated with the double rate of the drug cortexin.

Keywords:

cortexin
ischemic stroke
treatment of stroke
neuroprotection

Authors:

L.A. Belova

Ul'ianovskiĭ gosudarstvennyĭ universitet

V.V. Mashin

V.V. Abramova

A.N. Proshin

Ulyanovsk State University, Ulyanovsk

A.N. Ovsjannikova

Ulyanovsk State University, Ulyanovsk, Russia

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References:

  1. Skvortsova VI. Formation of system of rendering of medical aid to patients with cerebral stroke in the Russian Federation. Materials of all-Russian scientific-practical conference «Improvement of rendering of medical aid to patients with vascular diseases». M.: Real-Time; 2011.
  2. Mashin VV, Belova LA, Proshin AN, Abramov VV. the Influence of treatment with Cortexin in the likelihood of developing the multiple organ dysfunction SYNDROME in ischemic stroke. Farmateka. 2015;7:58-63.
  3. Mashin VV, Pinkova EA, Vinokurov LN, Gavrilov VN, Machine TV, Belova LA. Risk Factors for hypertensive encephalopathy and possible ways of their pharmacological correction. Medical almanac. 2011;1(14):195-197.
  4. Belova LA, Mashin VV. Venous blood circulation in chronic forms of cerebrovascular pathology. Ulyanovsk: Ulgu; 2015.
  5. Siegler JE, Martin-Schild S. Early Neurological Deterioration (END) after stroke: the END depends on the definition. International Journal of Stroke Organization. 2011;6:211-212. doi: 10.1111/j.1747-4949.2011.00596.x
  6. Mashin VV, Belova LA, Saprygina LV, Kravchenko MA, Varakin YuYa, Gnedovskaya EV, Suslina ZA. Risk Factors for development of cerebrovascular diseases according to the screening population of average age the city of Ulyanovsk. Annals of clinical and experimental neurology. 2014;8(1):4-9.
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  13. Gusev EI, Bogolepova NN. Cognitive impairment in cerebrovascular diseases. M.: Medpress-inform; 2013
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