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Belova L.A.

Ul'ianovskiĭ gosudarstvennyĭ universitet

Mashin V.V.

Abramova V.V.

Proshin A.N.

Ulyanovsk State University, Ulyanovsk

Ovsjannikova A.N.

Ulyanovsk State University, Ulyanovsk, Russia

Cognitive impairment in patients poluchennym ischemic stroke in the acute and early recovery periods in the process of neuroprotection low-dose drug cortexin

Authors:

Belova L.A., Mashin V.V., Abramova V.V., Proshin A.N., Ovsjannikova A.N.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2016;116(8‑2): 40‑43

DOI: 10.17116/jnevro20161168240-43

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To cite this article:

Belova LA, Mashin VV, Abramova VV, Proshin AN, Ovsjannikova AN. Cognitive impairment in patients poluchennym ischemic stroke in the acute and early recovery periods in the process of neuroprotection low-dose drug cortexin. S.S. Korsakov Journal of Neurology and Psychiatry. 2016;116(8‑2):40‑43. (In Russ.)
https://doi.org/10.17116/jnevro20161168240-43

 
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The purpose of the study. To study the effect of repeated low-dose course of neuroprotection by drug cortexin on cognitive impairment in the acute and early recovery periods of hemispheric ischemic stroke. Material and methods. The study involved 90 patients with poluchennym ischemic stroke. Patients of the first group received cortexin 20 mg (10+10) intramuscularly on the background of basic therapy, patients of the second group (n=30) received cortexin 20 mg (10+10) two courses for 10 days each with a break in between of 10 days, the patients of the third group — only basic therapy. For the objectification of cognitive impairment used a scale MMSE, a test of 5 words, the battery of frontal dysfunction, clock drawing test, MOCA test. Results. It was noted more rapid and complete regression of cognitive disorders in patients of the 1st and 2nd groups, in comparison with patients of the 3rd group. However, the best effect of the therapy was observed still in the group of patients treated with the double rate of the drug cortexin.

Keywords:

cortexin
ischemic stroke
treatment of stroke
neuroprotection

Authors:

Belova L.A.

Ul'ianovskiĭ gosudarstvennyĭ universitet

Mashin V.V.

Abramova V.V.

Proshin A.N.

Ulyanovsk State University, Ulyanovsk

Ovsjannikova A.N.

Ulyanovsk State University, Ulyanovsk, Russia

List of references:

  1. Skvortsova VI. Formation of system of rendering of medical aid to patients with cerebral stroke in the Russian Federation. Materials of all-Russian scientific-practical conference «Improvement of rendering of medical aid to patients with vascular diseases». M.: Real-Time; 2011.
  2. Mashin VV, Belova LA, Proshin AN, Abramov VV. the Influence of treatment with Cortexin in the likelihood of developing the multiple organ dysfunction SYNDROME in ischemic stroke. Farmateka. 2015;7:58-63.
  3. Mashin VV, Pinkova EA, Vinokurov LN, Gavrilov VN, Machine TV, Belova LA. Risk Factors for hypertensive encephalopathy and possible ways of their pharmacological correction. Medical almanac. 2011;1(14):195-197.
  4. Belova LA, Mashin VV. Venous blood circulation in chronic forms of cerebrovascular pathology. Ulyanovsk: Ulgu; 2015.
  5. Siegler JE, Martin-Schild S. Early Neurological Deterioration (END) after stroke: the END depends on the definition. International Journal of Stroke Organization. 2011;6:211-212. doi: 10.1111/j.1747-4949.2011.00596.x
  6. Mashin VV, Belova LA, Saprygina LV, Kravchenko MA, Varakin YuYa, Gnedovskaya EV, Suslina ZA. Risk Factors for development of cerebrovascular diseases according to the screening population of average age the city of Ulyanovsk. Annals of clinical and experimental neurology. 2014;8(1):4-9.
  7. Lindsay P, Furie KL, Davis SM, Dnnan GA, Norrvig D. World stroke organization global stroke services guidelines and action plan. Int J Stroke. 2014;9(100):4-13. doi: 10.1111/ijs.12371
  8. Belova L, Mashin V, Belova N. Hypertensive Encephalopathy: The Role Of Arteriovenous Interrelations In The Formation Of Its Clinical-Pathogenetic Subtypes. Experimental & Clinical Cardiology. 2014;20(7):892-898.
  9. Aliferova VM, Dadasheva MN, Doronin BM, Kovalenko AV, Lokshtanov TM, Martynov MYu, Meshkova KS, Salimov KA, Stakhovskaya LV, Chefranov JY, Shamalov N. Clinical efficacy and pharmacoeconomic characteristics of neuroprotection with low doses of Cortexin in the treatment of acute ischemic stroke. Journal of neurology and psychiatry. S.S. Korsakova. 2014;114:4:41-46.
  10. Belova LA, Mashin VV, Saprygina LV, Kravchenko MA, Gnedovskaya EV, Oschepkova EV, Varakin YuYa, Suslina ZA. Structure of cerebrovascular disease in an open population the working population of Ulyanovsk. Annals of clinical and experimental neurology. 2014;4(8):4-8.
  11. Leys D, Pasquier F. Post-stroke dementia. VASCOG, San Antonio; 2007:21. doi: 10.1017/cbo9780511586521.022
  12. Roman GC, Tatemichi TK, Erkinjutti T. Vascular dementia: diagnostic criteria for research studies. Report of the NINDS-Arien International Workshop. Neurology. 1993;43:250-260. doi: 10.1212/wnl.43.2.250
  13. Gusev EI, Bogolepova NN. Cognitive impairment in cerebrovascular diseases. M.: Medpress-inform; 2013
  14. Pendlebury ST, Rothwell PM. Prevalnce, incidence, and factors assotiated with prestrike and post-stroke dementia. Lancet Neurol. 2009;8:1006-1018. doi: 10.1016/s1474-4422(09)70236-4
  15. Folstein MF, Folstein SE, McHugh PR. Minimental state: a practical method for grading the copgnitive state of patients for the clinician. Journal of Psychiatric Research. 1975;12:189-198. doi: 10.1002/(sici)1099-1166(199805)13:5<285::aid-gps753>3.3.co;2-m
  16. Usoltseva N, Levin OS. The Ratio of cognitive and motor disturbances in patients with ischemic stroke. Modern approaches to neurorehabilitation. M.: 2007.

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