Objective. To investigate the effect of modern antiepileptic drugs on the hormonal profile of girls with epilepsy. Materials and methods. Levels of thyroid-stimulating hormone (TSH), thyrogiobulin antibodies (a/b TG), triiodothyronine (T3), thyroxine (T4), parathyroid hormone (P) and cortisol (C) were determined in the blood of 50 girls with epilepsy, aged from 8 to 17 years. In 19 girls, repeated measures of TSH, a/b TG, T3, T4 and C were taken 2-12 months after the first study. Valproate, carbamazepine, and topamax were used for treatment. Results. The highest content of TSH was found in girls, aged 8-17 years, treated with valproate. The presence of a/b TG was recorded in patients who did not receive antiepileptic drugs. T3, T4 and P levels were found in patients treated with phenobarbital or benzonal, topamax and valproate, respectively. C was detected in girls, aged 8-13 years, treated with phenobarbital or benzonal and in girls, aged 14-17 years, treated with trileptal. Repeated measures revealed the changes in all hormones in 64.86% of patients. Conclusion. Significant differences in the content of all hormones were found in girls treated with various antiepileptic drugs. Choice of drug, dosage and its correction should be made taking into account its impact on children's hormonal profile.