During the 2003-2006 period, the relationship of mortality from ischemic stroke (IS) and the environmental pollution in Yaroslavl, a Russian industrial center, was studied in 1983 patients with first ischemic stroke. A sample consisted of 978 men and 1005 women, the average age was 60.9±8.9 and 65.9±8.9 years, respectively. Additionally, the interactions between pollution, age, gender, and some of the major risk factors in these patients were analyzed.