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Kuzenkov V.S.

Moskovskiĭ gosudarstvennyĭ universitet im. M.V. Lomonosova

Krushinskiĭ A.L.

Moskovskiĭ gosudarstvennyĭ universitet im. M.V. Lomonosova

Reutov V.P.

NII neotlozhnoĭ detskoĭ khirurgii i travmatologii, Nauchnyĭ tsentr zdorov'ia deteĭ RAMN, Institut vyssheĭ nervnoĭ deiatel'nosti i neĭrofiziologii RAN, Moskva;
OOO "Gerofarm", Sankt-Peterburg

The effect of nitrates on the outcome of acute experimental ischemic stroke

Authors:

Kuzenkov V.S., Krushinskiĭ A.L., Reutov V.P.

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Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2012;112(12‑2): 35‑39

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THE EFFECT OF NITRATES ON THE OUTCOME OF ACUTE EXPERIMENTAL ISCHEMIC STROKE
THE EFFECT OF NITRATES ON THE OUTCOME OF ACUTE EXPERIMENTAL ISCHEMIC STROKE

To cite this article:

Kuzenkov VS, Krushinskiĭ AL, Reutov VP. The effect of nitrates on the outcome of acute experimental ischemic stroke. S.S. Korsakov Journal of Neurology and Psychiatry. 2012;112(12‑2):35‑39. (In Russ.)

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова. Спецвыпуски (S.S. Korsakov Journal of Neurology and Psychiatry (special issues))
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Abstract:

Effects of nitrates NaNO3, KNO3, Mg(NO3) 2 on animals (Wistar rats) were studied on the basis of the experimental model of ischemic stroke induced by the occlusion of two carotid arteries. The animals were divided into two groups: the main group (n=60) and the control group (n=30). Three series of experiments were conducted. In each experiment, the rats of the main group were treated with one of nitrates and the control group was treated with physiological solution. It has been shown that nitrates exert either positive or negative effect depending on the cation type, nitrate concentration and the duration of their action on the dynamics of neurologic disturbances. Conditions of the development of neuroprotective effect of nitrates are discussed.

Keywords:

ischemic stroke
nitrates
neuroprotective effect

Authors:

Kuzenkov V.S.

Moskovskiĭ gosudarstvennyĭ universitet im. M.V. Lomonosova

Krushinskiĭ A.L.

Moskovskiĭ gosudarstvennyĭ universitet im. M.V. Lomonosova

Reutov V.P.

NII neotlozhnoĭ detskoĭ khirurgii i travmatologii, Nauchnyĭ tsentr zdorov'ia deteĭ RAMN, Institut vyssheĭ nervnoĭ deiatel'nosti i neĭrofiziologii RAN, Moskva;
OOO "Gerofarm", Sankt-Peterburg

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